Early evaluation of targeted therapy effectiveness in non-small cell lung cancer by dynamic contrast-enhanced CT

Qiao, Pengyan; Zhang, H.-T.; Zhou, Juan; Li, M.; Ma, Jin-Lin; Tian, Ning; Xing, X.-D.; Li, G.-J.

doi:10.1007/s12094-015-1335-6

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Scans were executed with tube voltage ranging from 80 to 120 kVp and tube current of 50–115 mAs. In four studies, patients received between 40 and 50 mL non-ionic contrast media, while Qiao et al dosed contrast media according to weight [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…They also found significantly lower blood flow in responders than in non-responders 3–6 weeks after treatment. Qiao et al also found a significant decrease in blood flow in responders treated with anti-EGFR [ 30 ]. The same study showed that patients with a decrease in blood flow had a significantly longer median progression-free survival.…”

Section: Resultsmentioning

confidence: 99%

“…Four out of five studies that assessed the correlation between DCE-CT values and progression-free survival found that a decrease in permeability [ 28 ] or blood flow [ 19 , 29 , 30 ] corresponded to longer progression-free survival. Yao et al found similar results for blood flow in patients with advanced carcinoid tumor treated with anti-angiogenic drugs [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

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Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

et al. 2016

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The aim of this study was to provide an overview of the literature available on dynamic contrast-enhanced computed tomography (DCE-CT) as a tool to evaluate treatment response in patients with lung cancer. This systematic review was compiled according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only original research articles concerning treatment response in patients with lung cancer assessed with DCE-CT were included. To assess the validity of each study we implemented Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). The initial search yielded 651 publications, and 16 articles were included in this study. The articles were divided into groups of treatment. In studies where patients were treated with systemic chemotherapy with or without anti-angiogenic drugs, four out of the seven studies found a significant decrease in permeability after treatment. Four out of five studies that measured blood flow post anti-angiogenic treatments found that blood flow was significantly decreased. DCE-CT may be a useful tool in assessing treatment response in patients with lung cancer. It seems that particularly permeability and blood flow are important perfusion values for predicting treatment outcome. However, the heterogeneity in scan protocols, scan parameters, and time between scans makes it difficult to compare the included studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

et al. 2016

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“…To date, CTP based on a single-input model has been investigated for the evaluation of various treatments of lung cancer, including chemotherapy, targeted therapy, radiotherapy and interventional therapy. The majority of these studies confirmed CTP as a useful method and found that BF and permeability surface (PS) product decreased after treatment (33)(34)(35)(36)(37). Few studies have been carried out on thermal ablation, and the results have varied.…”

Section: Discussionmentioning

confidence: 98%

CT perfusion imaging can detect residual lung tumor early after radiofrequency ablation: a preliminary animal study on both tumoral and peri-tumoral region assessment

Cheng¹,

Wang²,

Yuan³

et al. 2022

J Thorac Dis

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Background: Radiofrequency ablation (RFA) is a minimally invasive procedure to treat lung cancer.Timely evaluation on residual lung tumor after RFA is crucial to the prognosis, hence, our objective is to assess CT perfusion (CTP) on detection of residual lung tumor early after RFA. Methods: CTP imaging was performed in 24 lung VX2 tumor models 1 day before and within 1 hour after RFA. CTP maps with dual-input (n=24) and single-input [n=13, with predominant ground glass opacity (GGO) after RFA] models were generated using the maximal slope method. Regions of interest were independently placed on the maximal cross-sectional tumor before and after RFA and on GGO after RFA by two thoracic radiologists. The bronchial flow (BF), pulmonary flow (PF) and perfusion index (PI) were compared between pre-RFA and post-RFA images. The parameters (BF, PF and PI of tumor; PF of GGO) of the complete and incomplete RFA groups were compared based on NADH and TUNEL staining and were correlated with the microvascular density (MVD). Results: The BF and PF decreased after RFA (all P values <0.03). The decrease in BF and PF (ΔBF and ΔPF) in the complete RFA group was higher (P=0.01; 0.02). The areas under the curve (AUC) of ΔBF and ΔPF at 14.85 and 17.25 mL/min/100 mL in determination of tumor with complete ablation were 0.80 and 0.78, respectively. ΔBF was positively correlated with MVD (P=0.046, r=0.468). PF of GGO with incomplete RFA was higher (P=0.001). The AUC of PF ≤29.4 mL/min/100 mL in determination of tumor with complete ablation was 0.99. Conclusions: CTP could detect residual lung tumor early after RFA in a rabbit model, which might provide a clinical solution to early treatment assessment after RFA.

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“…CT perfusion was lower in RECIST responders versus non-responders at week 3 and week 6 respectively. Another study showed dynamic CT perfusion can used to early evaluate targeted therapy efficacy 7 days post-treatment and reduced blood perfusion suggests tumor sensitivity to therapy and treatment effectiveness [45].…”

Section: Prognostic Biomarker and Response Predictionmentioning

confidence: 99%

CT Perfusion Imaging: A Valuable and Feasible Resolution of Pulmonary Nodules

Chen¹,

Sun²

2019

Advanced Ultrasound in Diagnosis and Therapy

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CT perfusion imaging, a non-invasive functional imaging method, can accurately reflect the hemodynamic changes of pulmonary nodules. It plays an important role in the diagnosis, differential diagnosis, treatment effect assessment and prognosis prediction. This article reviews the hemodynamics of pulmonary nodules, the characteristics of the blood flow of CT perfusion imaging of the pulmonary nodules, the characteristics of the CT perfusion technique of the pulmonary nodules and the status of the clinical application in the characterization of pulmonary nodules.

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Early evaluation of targeted therapy effectiveness in non-small cell lung cancer by dynamic contrast-enhanced CT

Abstract: DCE-CT can evaluate targeted therapy efficacy at 7 days post-treatment. Decreased primary tumor diameter and BP indicate tumor sensitivity to therapy; increased BP with unchanged tumor diameter suggests the tumor is not sensitive to therapy. Reduced BP suggests treatment effectiveness.

Cited by 7 publications

References 20 publications

Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

CT perfusion imaging can detect residual lung tumor early after radiofrequency ablation: a preliminary animal study on both tumoral and peri-tumoral region assessment

CT Perfusion Imaging: A Valuable and Feasible Resolution of Pulmonary Nodules

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