Early Filariasis (Bancrofti) in American Soldiers

Hodge, I; Denhoff, Eric; Veer, Joseph B. Vander

doi:10.1097/00000441-194508000-00012

Cited by 12 publications

(5 citation statements)

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“…Systemic involvement may be greater in 'immune-naïve' immigrants to endemic areas. Classical AFL was described extensively in US and European soldiers during World War II [11,82-85]. AFL is commonly observed following individual or mass treatment with DEC [86,87], and this is considered evidence of the drug's macrofilaricidal efficacy [88-90].…”

Section: Acute Inflammatory Episodes (Acute Attacks)mentioning

confidence: 99%

Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature

2007

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The Global Programme to Eliminate Lymphatic Filariasis (GPELF) has two major goals: to interrupt transmission of the parasite and to provide care for those who suffer the devastating clinical manifestations of the disease (morbidity control). This latter goal addresses three filariasis-related conditions: acute inflammatory episodes; lymphoedema; and hydrocele. Research during the last decade has confirmed the importance of bacteria as a cause of acute inflammatory episodes in filariasis-endemic areas, known as acute dermatolymphangioadenitis (ADLA). Current lymphoedema management strategies are based on the central role of ADLA as a trigger for lymphoedema progression. Simple intervention packages are in use that have resulted in dramatic reductions in ADLA rates, a lower prevalence of chronic inflammatory cells in the dermis and subdermis, and improvement in quality of life. During the past decade, the socioeconomic impact of ADLA and lymphoedema in filariasis-endemic areas has received increasing attention. Numerous operational research questions remain to be answered regarding how best to optimize, scale up, monitor, and evaluate lymphoedema management programmes. Of the clinical manifestations targeted by the GPELF, hydrocele has been the focus of the least attention. Basic information is lacking on the effectiveness and complications of hydrocele surgery and risk of post-operative hydrocele recurrence in filariasis-endemic areas. Data on the impact of mass administration of antifilarial drugs on filarial morbidity are inconsistent. Several studies report reductions in acute inflammatory episodes, lymphoedema, and/or hydrocele following mass drug administration, but other studies report no such association. Assessing the public health impact of mass treatment with antifilarial drugs is important for programme advocacy and morbidity control strategies. Thus, although our knowledge of filariasis-related morbidity and its treatment has expanded in recent years, much work remains to be done to address the needs of more than 40 million persons who suffer worldwide from these conditions.

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Section: Acute Inflammatory Episodes (Acute Attacks)mentioning

confidence: 99%

Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature

2007

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“…Experience during World War II with American soldiers travelling through endemic areas [10,11] showed that initial infection of a naive host causes an intense inflammatory reaction, particularly in the lymph nodes. The inflammation causes temporary obstruction, which later re‐canalizes.…”

Section: Biologymentioning

confidence: 99%

The role of the urologist in the treatment and elimination of lymphatic filariasis worldwide

deVries

2002

BJU International

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“…They rapidly develop in¯ammatory pathology, including lymphadenitis, hepatomegaly and splenomegaly. Such manifestations were initially seen in soldiers who were posted in ®larial-endemic areas in south-east Asia (Wartmann, 1947;King, 1944;Huntington et al, 1944;Hodge et al, 1945;Galliard, 1957) and in humans experimentally infected with ®larial parasites (reviewed in Nutman, 1991). Similar manifestations were reported among transmigrants in Indonesia, where populations were relocated from nonendemic areas to areas endemic for ®lariasis (Partono, 1987).…”

Section: Clinical Manifestations In Expatriates and Transmigrantsmentioning

confidence: 85%

Blood‐borne Filarial Infections: Wuchereria bancrofti , Brugia malayi , Brugia timori , Loa loa , Mansonella perstans and Mansonella ozzardi

Nutman

2001

Principles and Practise of Clinical Parasitology

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Early Filariasis (Bancrofti) in American Soldiers

Cited by 12 publications

References 0 publications

Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature

Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature

The role of the urologist in the treatment and elimination of lymphatic filariasis worldwide

Blood‐borne Filarial Infections: Wuchereria bancrofti , Brugia malayi , Brugia timori , Loa loa , Mansonella perstans and Mansonella ozzardi

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