Early handling and group housing: Effect on development and response to stress in the rat

Winokur, G.; Stern, John A.; Taylor, Rita L.

doi:10.1016/0022-3999(59)90043-1

Cited by 20 publications

(2 citation statements)

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“…In the present study, handling experienced after weaning resulted in an increased susceptibility to gastric erosions. The finding that animals handled during the preweaning period are less susceptible to erosions is consistent with previous data (12), but the increase in susceptibility among animals handled after weaning is inconsistent with previous results (15,16). There is no readily apparent explanation for this difference, especially since the animals handled after weaning did not display any noteworthy differences in behavior or in their plasma pepsinogen levels relative to either nonhandled animals or animals handled prior to weaning.…”

Section: Discussionsupporting

confidence: 86%

“…Of particular relevance to the present research are the studies that have shown that early life experiences and the prevailing social environment, singly or in interaction, are capable of influencing the adult animal's susceptibility to immobilization-induced gastric erosions. For example, group-housed rats are more susceptible to lesions than animals caged individually (12,13,14); rats subjected to daily handling during early life are less susceptible to erosions than unmanipulated control animals (12,15,16); and the difference at adulthood between handled and nonhandled animals is accentuated when such animals are housed individually rather than in groups (12).…”

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confidence: 98%

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Effects of Early Experience and Differential Housing on Susceptibility to Gastric Erosions in Lesion-Susceptible Rats

Ader¹

1970

Psychosomatic Medicine

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A population of lesion-susceptible rats was derived from the mating of control females with males from a selectively bred strain of ulcer-susceptible animals. Litters of lesion-susceptible and control animals were randomly assigned to groups which were handled daily throughout the first or second 3 weeks of life or which remained undisturbed. Half of each subgroup was subsequently housed individually or in groups of 4-5/cage. Emotional reactivity was reduced in grouphoused animals relative to those individually housed, and in the individually housed, handled group relative to the nonhandled control population; handling did not influence emotional reactivity in the lesion-susceptible population. These lesion-susceptible animals were more susceptible to gastric erosions and had higher plasma pepsinogen levels than did control animals. There were also experientially determined changes in pepsinogen level, but neither these nor the differences in emotional reactivity were related to lesion susceptibility. There was an interaction between early experience and differential housing in determining lesion susceptibility; among group-housed animals there were no effects from early experience, but among individually housed animals, handling experienced during the first 3 weeks of life decreased susceptibility to gastric erosions in the lesion-susceptible as well as in the control population. It was concluded that early life experiences can modify a genically determined susceptibility to disease.Previous research (1) has demonstrated the nature of the psychophysiologic chanthat early life experiences are capable ol ges effected by a given type of early experiinfluencing susceptibility to disease in ani-ence-and the nature of the pathogenic mal subjects. The principal factors which stimulation to which the individual is exdetermine whether and how susceptibility posed. Potentially pathogenic stimuli do to disease will be influenced are the nature not act in a vacuum; they are superimof the early experience-more specifically, posed upon a psychophysiologic state which is characteristic of the individual

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Section: Discussionsupporting

confidence: 86%

mentioning

confidence: 98%