Early healing of the alveolar process after tooth extraction: an experimental study in the beagle dog

Abstract

Minor vertical bone reduction in both the buccal and lingual socket walls were observed. A marked horizontal reduction of the buccal bone wall was observed mostly in its coronal aspect.

Wound Healing Problems in the Mouth

“…Healing after a tooth extraction follows the same pattern, with the inclusion of a bone healing process (Larjava, 2012; Discepoli et al, 2013). Minutes after the tooth is extracted, the alveoli are closed via blood clotting.…”

“…Granulation tissue comprises a dense population of macrophages, fibroblasts, capillary networks, fibronectin, hyaluronic acid and endothelial cells (Rodriguez-Merchan, 2012; Discepoli et al, 2013). Macrophages, fibroblasts, and endothelial cells are interdependent during granulation tissue formation (Rodriguez-Merchan, 2012; Discepoli et al, 2013). Hypoxia is an important trigger for neovascularization during this phase (Schreml et al, 2010; Larjava, 2012).…”

“…After 1 week, the blood clot is replaced with granulation tissue. After 8 weeks, the extraction cavity is filled with bone (Larjava, 2012; Discepoli et al, 2013). The bone remodeling process continues for 6 months after the extraction, and is accompanied by a loss of alveolar width and length due to resorption and remodeling (Discepoli et al, 2013).…”

“…After 8 weeks, the extraction cavity is filled with bone (Larjava, 2012; Discepoli et al, 2013). The bone remodeling process continues for 6 months after the extraction, and is accompanied by a loss of alveolar width and length due to resorption and remodeling (Discepoli et al, 2013). The amount of bone loss varies among individuals, and depends on the location, the presence of adjacent teeth, the treatment protocol, smoking behavior, and the use of membranes and bone substitutes (Trombelli et al, 2008).…”

Caracterização morfométrica e molecular do papel de citocinas pró e anti-inflamatórias no processo de reparo ósseo alveolar em condições homeostáticas e infecciosas

“…O reparo ósseo pós-exodontia vem sendo descrito ao longo de anos em estudos clínicos em humanos e experimentais em diferentes espécies como macacos (Scala, Lang et al 2013), cães (Cardaropoli, Araujo et al 2003;Discepoli, Vignoletti et al 2013), coelhos (Lalani, Wong et al 2003;Lalani, Wong et al 2004;Lalani, Wong et al 2005), ratos (Devlin, Hoyland et al 1997;Kanyama, Kuboki et al 2003;Accorsi-Mendonca, Paiva et al 2008) e inclusive alguns trabalhos em camundongos (Grewe and Felts 1969;). Embora já esteja bem consolidado que o reparo ósseo alveolar é um Andreia Espíndola Vieira processo complexo, sequencial e bem regulado, envolvendo diferentes tipos de células e tecidos (Korpi, Astrom et al 2009;Lin, Rios et al 2011 Em nosso estudo, utilizamos animais knockouts em que a ausência de determinada citocina ou mais especificamente do seu receptor, foi uma ferramenta interessante para a elucidação de papéis individuais de tais mediadores.…”