Wound Healing Problems in the Mouth

Politis, Constantinus; Schoenaers, Joseph; Jacobs, Reinhilde; Agbaje, Jimoh Olubanwo

doi:10.3389/fphys.2016.00507

Cited by 173 publications

(184 citation statements)

References 61 publications

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“…For CSH the clinical signs assessed were bleeding, fibrin, and the absence thereof, representing haemostasis in its schematic subdivisions (primary, secondary, and tertiary). Primary haemostasis, subclassified into a vascular and a platelet phase, is a crucial step in would healing, since the interruption of blood flow and clotting allow further steps of healing [ 16 17 18 ]. Slight bleeding is common for the first few hours after surgery, but it may occur for some additional hours or for 2–3 days due to suture loosening, flap instability, or dehiscence, which impede outcomes in the course of further wound healing [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Early Wound Healing Score: a system to evaluate the early healing of periodontal soft tissue wounds

Marini

Rojas

Sahrmann

et al. 2018

J Periodontal Implant Sci

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PurposeNumerous indices have been proposed to analyse wound healing in oral soft tissues, but each has specific shortcomings. A new method of analysis, the Early Wound Healing Score (EHS), was evaluated in the present study. The aim was to assess more accurately early healing by primary intention of surgical incisions in periodontal soft tissues.MethodsTwenty-one patients were treated with different surgical procedures comprising 1 or 2 vertical releasing incisions as part of a surgical access flap. Twenty-four hours after surgery, early wound healing at the vertical releasing incisions was assessed using the EHS. This score assessed clinical signs of re-epithelialization (CSR), clinical signs of haemostasis (CSH), and clinical signs of inflammation (CSI). Since complete wound epithelialization was the main outcome, the CSR score was weighted to be 60% of the total final score. Accordingly, a score of 0, 3, or 6 points was possible for the assessment of CSR, whereas scores of 0, 1, or 2 points were possible for CSH and CSI. Higher values indicated better healing. Accordingly, the score for ideal early wound healing was 10.ResultsThirty vertical releasing incisions were assessed in 21 patients. At 24 hours after incision, 16 vertical releasing incisions (53.33%) received the maximum score of CSR, while 6 cases (20%) received an EHS of 10. None of the cases received 0 points.ConclusionThe EHS system may be a useful tool for assessing early wound healing in periodontal soft tissue by primary intention after surgery.

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Section: Discussionmentioning

confidence: 99%

Early Wound Healing Score: a system to evaluate the early healing of periodontal soft tissue wounds

Marini

Rojas

Sahrmann

et al. 2018

J Periodontal Implant Sci

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“…Wound healing is a complex, multistage biological process including three distinct and overlapping phases of inflammation, proliferation, and remodeling (Gurtner, Werner, Barrandon, & Longaker, ; Politis, Schoenaers, Jacobs, & Agbaje, ). Many different types of cells and bioactive molecules contribute to a well‐orchestrated cutaneous injury repair.…”

Section: Introductionmentioning

confidence: 99%

Promising effects of exosomes isolated from menstrual blood‐derived mesenchymal stem cell on wound‐healing process in diabetic mouse model

Dalirfardouei

Jamialahmadi

Jafarian³

et al. 2019

J Tissue Eng Regen Med

164

136

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Wound healing is a complicated process that contains a number of overlapping and consecutive phases, disruption in each of which can cause chronic nonhealing wounds. In the current study, we investigated the effects of exosomes as paracrine factors released from menstrual blood-derived mesenchymal stem cells (MenSCs) on wound-healing process in diabetic mice. The exosomes were isolated from MenSCs conditioned media using ultracentrifugation and were characterized by scanning electron microscope and western blotting assay. A full thickness excisional wound was created on the dorsal skin of each streptozotocin-induced diabetic mouse. The mice were divided into three groups as follows: phosphate buffered saline, exosomes, and MenSC groups. We found that MenSC-derived exosomes can resolve inflammation via induced M1-M2 macrophage polarization. It was observed that exosomes enhance neoangiogenesis through vascular endothelial growth factor A upregulation.Re-epithelialization accelerated in the exosome-treated mice, most likely through NF-κB p65 subunit upregulation and activation of the NF-κB signaling pathway. The results demonstrated that exosomes possibly cause less scar formation through decreased Col1:Col3 ratio. These notable results showed that the MenSC-derived exosomes effectively ameliorated cutaneous nonhealing wounds. We suggest that exosomes can be employed in regenerative medicine for skin repair in difficult-toheal conditions such as diabetic foot ulcer. KEYWORDSangiogenesis, diabetic murine model, excisional wound, exosome, menstrual blood, mesenchymal stem cell

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“…Studies investigating this aspect finished the studies after 5 days without investigating longer lasting effects and wound closure [ 10 ]. Physiologically this occurs on day 4–14 and leads to serum-like environmental conditions and therefore altered corrosion rates [ 25 ]. This study investigates those changing conditions after wound closure, by using a Hank’s salt solution, which simulates physiological pH and isotonic salt concentration.…”

Section: Introductionmentioning

confidence: 99%

Impact of Wound Closure on the Corrosion Rate of Biodegradable Mg-Ca-Zn Alloys in the Oral Environment

et al. 2020

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Magnesium alloys have exhibited a rapid rate of corrosion and thus early implant failure, so this study was designed to investigate the longer-term effects and in particular on wound closure. The aim of the study is to evaluate Mg-Ca-Zn Alloys as promising biodegradable implants in the field of maxillofacial surgery, which have so far never been evaluated for the changing conditions from a saliva to a serum-like environment after wound closure. Magnesium-0.6/calcium-0.8 wt.% zinc alloys were either immersed for 10 days in artificial saliva or 10 days in Hank’s salt solution as control groups. The test group was transferred from artificial saliva to Hank’s salt solution after 5 days in order to simulate wound closure. Corrosion rates were determined by immersion testing. Additional electron microscopy and energy dispersive X-ray spectroscopy (EDX) were performed. Prior artificial saliva exposure led to significantly decreased (p = 0.0272) corrosion rates after transfer to Hank’s solution in comparison to sole Hank’s solution exposure (0.1703 vs. 0.6675 mg/(cm2·day)) and sole artificial saliva exposure (0.3180 mg/(cm2·day)), which both exhibit a strong increase after 5 days. The results were in accordance with the scanning electron microscopy and EDX pictures. Prior saliva exposure could protect from increasing corrosion rates after wound closure. Thus Mg-Ca-Zn Alloys are promising future implant alloys in oral surgery, whereas other surgical fields without saliva exposure have to deal with accelerated corrosion rates after 5 days.

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Wound Healing Problems in the Mouth

Cited by 173 publications

References 61 publications

Early Wound Healing Score: a system to evaluate the early healing of periodontal soft tissue wounds

Early Wound Healing Score: a system to evaluate the early healing of periodontal soft tissue wounds

Promising effects of exosomes isolated from menstrual blood‐derived mesenchymal stem cell on wound‐healing process in diabetic mouse model

Impact of Wound Closure on the Corrosion Rate of Biodegradable Mg-Ca-Zn Alloys in the Oral Environment

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