Early Hyperbaric Oxygen Therapy for Retinal Artery Occlusion

Beiran, Itzchak; Goldenberg, Ilan; Adir, Yochai; Tamir, Ada; Shupak, Avi; Miller, Benjamin

doi:10.1177/112067210101100405

Cited by 69 publications

(43 citation statements)

References 10 publications

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“…87 Improvement of visual acuity was reported in 10 of 12 patients treated with IV recombinant tissue plasminogen activator (rTPA), but all had residual field defects. 88 A systematic protocol that included multiple modalities with observations of retinal arterial flow following each step was shown to result in remarkable visual improvement compared with arbitrary treatment choices. 89 Beneficial effects on vision have been reported following selective ophthalmic artery catheterization infusion of tPA 90,91 or urokinase.…”

Section: Purvin and Kawasakimentioning

confidence: 99%

Neuro-Ophthalmic Emergencies for the Neurologist

Purvin¹,

Kawasaki²

2005

The Neurologist

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A variety of acute neurologic disorders present with visual signs and symptoms. In this review the authors focus on those disorders in which the clinical outcome is dependent on timely and accurate diagnosis. The first section deals with acute visual loss, specifically optic neuritis, ischemic optic neuropathy (ION), retinal artery occlusion, and homonymous hemianopia. The authors include a discussion of those clinical features that are helpful in distinguishing between inflammatory and ischemic optic nerve disease and between arteritic and nonarteritic ION. The second section concerns disc edema with an emphasis on the prevention of visual loss in patients with increased intracranial pressure. The third section deals with abnormal ocular motility, and includes orbital inflammatory disease, carotid-cavernous fistulas, painful ophthalmoplegia, conjugate gaze palsies, and neuromuscular junction disorders. The final section concerns pupillary abnormalities, with a particular emphasis on the dilated pupil and on carotid artery dissection. Throughout there are specific guidelines for the management of these disorders, and areas are highlighted in which there is ongoing controversy.

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Section: Purvin and Kawasakimentioning

confidence: 99%

Neuro-Ophthalmic Emergencies for the Neurologist

Purvin¹,

Kawasaki²

2005

The Neurologist

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“…1,2 Such complications have been treated by various methods, including laser photocoagulation, systemic corticosteroids and recently, intravitreal injections of triamcinolone acetonide. 3 HBOT has been suggested in the treatment of various retinal pathological conditions, 4 and optic neuropathies, including radiation-induced optic neuropathy. 5 In our present case, we report the response of irradiation retinopathy and optic neuropathy to HBOT with marked improvement in the clinical appearance of the fundus and the visual field.…”

Section: Commentmentioning

confidence: 99%

“…1 Several studies have isolated bacteria inside the operating room on everything from the ventilation systems to surgical drapes, most commonly isolating coagulase-negative Staphylococcus. [2][3][4][5] Case report In order to investigate the potential of ophthalmic operating microscopes to contaminate the surgical field, we cultured four ophthalmic operating microscopes, two at a university hospital and two at a Veteran's Administration hospital. All four operating rooms were frequently used by multiple resident and faculty physicians for ophthalmic surgery.…”

Section: Commentmentioning

confidence: 99%

Severe radiation retinopathy and optic neuropathy after brachytherapy for choroidal melanoma, treated by hyperbaric oxygen

Gall

Leiba

Handzel

et al. 2007

Eye

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“…In ophthalmology, HBO was reported to be beneficial in the treatment of patients with arterial retinal occlusions and anterior ischemic optic neuropathy [43][44][45][46][47][48] . Beiran et al reported significant improvement in visual outcome in 83% of the patients treated with HBO as compared with only 30% improvement in the control group 47 .…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective effect of hyperbaric oxygen treatment on laser-induced retinal damage in rats

Vishnevskia-Dai

Belokopytov

Dubinsky

et al. 2005

Ophthalmic Technologies XV

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Retinal damage induced by mechanical trauma, ischemia or laser photocoagulation increases considerably by secondary degeneration processes. The spread of damage may be ameliorated by neuroprotection that is aimed at reducing the extent of the secondary degeneration and promote healing processes. Hyperbaric oxygen (HBO) treatment consists of inspiration of oxygen at higher than one absolute atmospheric pressure. Improved neural function was observed in patients with acute brain trauma or ischemia treated with HBO. This study was designed to evaluate the neuroprotective effect of hyperbaric oxygen (HBO) on laser induced retinal damage in a rat model. Standard argon laser lesions were created in 25 pigmented rats divided into three groups: Ten rats were treated immediately after the irradiation with HBO three times during the first 24 hr followed by 12 consecutive daily treatments. Five rats received a shorter treatment regimen of 10 consecutive HBO treatments. The control group (10 rats) underwent the laser damage with no additional treatment. The retinal lesions were evaluated 20 days after the injury. All outcome measures were improved by the longer HBO treatment (P<0.01). The shorter HBO treatment was less effective, showing an increase only in nuclei density at the central area of lesion (P< 0.01). Hyperbaric oxygen seems to exert a neuroprotective effect on laserinduced retinal damage in a rat model. In the range of HBO exposures studied, longer exposure provides more neuroprotection. These results encourage further evaluation of the potential therapeutic use of hyperbaric oxygen in diseases and injuries of the retina.

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Early Hyperbaric Oxygen Therapy for Retinal Artery Occlusion

Abstract: Early HBO therapy appears to have a beneficial effect on visual outcome in patients with RAO. Further large-scale prospective controlled studies are needed to confirm this.

Cited by 69 publications

References 10 publications

Neuro-Ophthalmic Emergencies for the Neurologist

Neuro-Ophthalmic Emergencies for the Neurologist

Severe radiation retinopathy and optic neuropathy after brachytherapy for choroidal melanoma, treated by hyperbaric oxygen

The neuroprotective effect of hyperbaric oxygen treatment on laser-induced retinal damage in rats

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