Early identification and treatment for peripheral arterial disease in patients with ischemic cerebrovascular disease

Abstract

Ischemic cerebrovascular disease (ICVD) is a major cause of mortality and disability worldwide and is often caused by atherosclerosis. As a systemic disease, atherosclerosis usually affects multiple vascular beds, mainly including cerebral, coronary, and peripheral arteries. Therefore, ICVD is easily complicated by lower-extremity peripheral arterial disease (PAD). ICVD patients with PAD have more serious symptoms and a worse prognosis, however, neurologists might neglect the evaluation and management of the coexistent PAD, and there is still a lack of consensuses about the diagnosis and treatment for such patients. By summarizing relevant research progresses, this review showed that duplex ultrasound had more advantages in the early screening and evaluation of PAD in ICVD patients among multiple methods to diagnose PAD. Furthermore, the current evidence seems to support that single-drug antiplatelet can be used as the basic treatment, and new antithrombotic strategies, such as ticagrelor only or aspirin combined with low-dose rivaroxaban are expected to further reduce the incidence of stroke for ICVD patients with PAD. More effective treatments would be explored by large-scale trials to guide the clinical management to prevent secondary stroke for such patients.

Protective effects of brain and muscle ARNT-like gene 1 on oxidized low-density lipoprotein-induced human brain microvascular endothelial cell injury by alleviating ferroptosis

“…Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading cause of cerebrovascular diseases. 14 Endothelial dysfunction caused by oxidative lipid deposition is the main cause of early atherosclerosis. Therefore, elucidating the mechanism of endothelial dysfunction induced by oxidative lipid deposition may provide promising intervention targets for the treatment of atherosclerosis Herein, we found that ox-LDL-induced HBMEC damage, ferroptosis, and reduced BMAL1 expression in HBMECs, which were all reversed by ferrostatin-1 treatment.…”

Avaliação sistemática dos preditores de acidente vascular cerebral em pacientes com doença arterial periférica

“…A literatura corrente ainda sugere que há áreas significativas de incerteza quanto à eficácia das intervenções destinadas a mitigar o risco de AVC em pacientes com DAP. Este panorama requer uma investigação mais aprofundada e sistematizada para esclarecer essas incertezas (Li;Ma, 2023).…”