Early-life antibiotic use is associated with wheezing among children with high atopic risk: a prospective European study

Sun, Wenjie; Svendsen, Erik; Karmaus, Wilfried; Kuehr, Joachim; Förster, Johannes

doi:10.3109/02770903.2014.999284

Cited by 36 publications

(9 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study population, a large proportion of infants were exclusively breastfed for the first 6 months. In addition, the median duration of breastfeeding was 10.5 months, which more closely matches the population studied by Kopp et al 6 Given the multitude of factors that may affect the risk of allergic disease, the effect of supplementation with a single probiotic species may only be discernable in high-risk infants who are also born into high-risk scenarios because of altered gastrointestinal microbiota development (eg, cesarean delivery, early broad spectrum antibiotic exposure, 28,29 and perhaps lack of breast milk exposure).…”

Section: Figuresupporting

confidence: 73%

Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Figuresupporting

confidence: 73%

Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial

et al. 2017

View full text Add to dashboard Cite

show abstract

“…children who received antibiotics have higher incidence of allergy and asthma [31–33]. Besides these seemingly negative effects on immune development, one can imagine that it may also be possible to positively modulate immune development by providing specific diets or feed additives that influence the microbial colonization of the gut.…”

Section: Discussionmentioning

confidence: 99%

Perturbation of microbiota in one-day old broiler chickens with antibiotic for 24 hours negatively affects intestinal immune development

Schokker

Jansman

Veninga³

et al. 2017

BMC Genomics

View full text Add to dashboard Cite

BackgroundGut microbial colonization and development of immune competence are intertwined and are influenced by early-life nutritional, environmental, and management factors. Perturbation of the gut microbiome at young age affects the crosstalk between intestinal bacteria and host cells of the intestinal mucosa.ResultsWe investigated the effect of a perturbation of the normal early life microbial colonization of the jejunum in 1-day old chickens. Perturbation was induced by administering 0.8 mg amoxicillin per bird per day) via the drinking water for a period of 24 h. Effects of the perturbation were measured by 16S rRNA profiling of the microbiome and whole genome gene expression analysis. In parallel to what has been observed for other animal species, we hypothesized that such an intervention may have negative impact on immune development.Trends were observed in changes of the composition and diversity of the microbiome when comparing antibiotic treated birds with their controls. in the jejunum, the expression of numerous genes changed, which potentially leads to changes in biological activities of the small intestinal mucosa. Validation of the predicted functional changes was performed by staining immune cells in the small intestinal mucosa and a reduction in the number of macrophage-like (KUL01+) cells was observed due to a direct or indirect effect of the antibiotic treatment. We provide evidence that a short, early life antibiotic treatment affects both the intestinal microbiota (temporarily) and mucosal gene expression over a period of 2 weeks.ConclusionThese results underscore the importance of early life microbial colonization of the gut in relation to immune development and the necessity to explore the capabilities of a variety of early life dietary and/or environmental factors to modulate the programming for immune competence in broilers.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-017-3625-6) contains supplementary material, which is available to authorized users.

show abstract

“…74,75 Similar studies on full term infants receiving perinatal antibiotics also showed that antibiotic treatment as associated with less bacterial diversity along with higher proportions of Proteobacteria and Enterobacteriaceae and lower proportions of Bifidobacterium and Lactobacillus (Table 1). 76,77 When considering the relationship between the development of allergic disease and early-life antibiotic exposure, there appears to be an association between both prenatal 78,79 and postnatal 79–81 antibiotic exposure and asthma. It should be noted, however, that many studies might be confounded by an increased treatment of respiratory infections at an early age when manifestations of asthma may be indistinguishable from infection.…”

Section: The Influence Of the Microbiome In Allergic Diseasementioning

confidence: 99%

Gut Microbiome and the Development of Food Allergy and Allergic Disease

Prince

Mandel

Nadeau

et al. 2015

Pediatric Clinics of North America

View full text Add to dashboard Cite

The prevalence of food allergy and other allergic diseases continues to rise within the industrialized world, yet the cause of this epidemic remains elusive. Environmental factors such as microbial exposures have more recently been implicated as one possible driving factor behind the increasing burden of allergic disease. The impact of gut microbiome on human development, nutritional needs, and disease has become evident with advances in our ability to study these complex communities of microorganisms, and there is a growing appreciation for the role of the microbiome in immune regulation. Several studies have examined associations between changes in the commensal microbiota and the development of asthma, allergic rhinitis, and asthma, but far less have evaluated the impact of the microbiome on the development of food allergy. In this article we review the human gastrointestinal microbiome, focusing on the theory and evidence for its role in the development of IgE-mediated food allergy and other allergic diseases.

show abstract

Early-life antibiotic use is associated with wheezing among children with high atopic risk: a prospective European study

Abstract: In European children with a familial risk for allergic sensitization, we found a positive association between macrolide use in the first year of life and wheezing until 36 months old which was independent of the effect of respiratory infection.

Cited by 36 publications

References 52 publications

Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial

Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial

Perturbation of microbiota in one-day old broiler chickens with antibiotic for 24 hours negatively affects intestinal immune development

Gut Microbiome and the Development of Food Allergy and Allergic Disease

Contact Info

Product

Resources

About