Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

“…107 No adoptive transfer experiments were performed to test the in vivo function of the DCs in that study. We also found that, although DCs from adult mice with neonatal exposure to killed bacteria inhibited the development of allergic reactions in recipient mice after adoptive transfer, DCs from young mice with short exposure to the same bacteria failed to inhibit the development of allergic reactions; this failure was associated with the lack of IL-10 production by the latter DCs (Jiao L, Yang X, unpubl.…”

Section: Cd25mentioning

confidence: 99%

Role of dendritic cells: a step forward for the hygiene hypothesis

Yang

Gao

2010

Cell Mol Immunol

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The hygiene hypothesis was proposed more than two decades ago, but its mechanism remains unclear. This review focuses on recent advances in the field, especially on the role played by dendritic cells (DCs) and their modulating effects on various infections and allergic diseases, including allergic asthma. DCs isolated from mice long after the resolution of an infection were reported to have a significant modulating effect on allergen-specific Th2 responses in both in vitro and in vivo systems. These DCs showed DC1-like and/or tolerogenic DC capacity, which allowed for the inhibition of allergic responses by immune deviation (enhancing Th1 response) and immune regulation (through regulatory T-cell and Th2 hyporesponsiveness) mechanisms. These findings represented a significant advance in the elucidation of the mechanisms underlying the hygiene hypothesis. Further investigation on the mechanisms by which DCs are 'educated' by infectious agents and the influence of the type, time, and extent of infections on this 'education' process will help us understand immune regulation in disease settings and in the rational design of preventive/therapeutic approaches to allergy/asthma and infections.

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“…Recently, extensive research has focused on the significance of both the nature and timing of respiratory infections in asthma, and whether infection-induced skewing of the T-cell phenotype can influence the progression of asthma [4][5][6][7][8].…”

mentioning

confidence: 99%

“…Although certain types of infections drive and/or exacerbate asthma [6][7][8][9][10], several studies support a role for some respiratory infections, such as mycobacterial infections, in suppressing Th2-driven allergic disease [4,11]. Administration of mycobacterial components inhibits allergic airway disease (AAD); however, the efficacy of mycobacterial treatment in preventing allergic diseases in human trials has been varied, with decreases in the severity of atopic dermatitis but no affect on allergic asthma [11][12][13].…”

mentioning

confidence: 99%

Streptococcus pneumoniaeinfection suppresses allergic airways disease by inducing regulatory T-cells

Preston¹,

Thorburn²,

Starkey³

et al. 2010

Eur Respir J

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An inverse association exists between some bacterial infections and the prevalence of asthma. We investigated whether Streptococcus pneumoniae infection protects against asthma using mouse models of ovalbumin (OVA)-induced allergic airway disease (AAD).Mice were intratracheally infected or treated with killed S. pneumoniae before, during or after OVA sensitisation and subsequent challenge. The effects of S. pneumoniae on AAD were assessed.Infection or treatment with killed S. pneumoniae suppressed hallmark features of AAD, including antigen-specific T-helper cell (Th) type 2 cytokine and antibody responses, peripheral and pulmonary eosinophil accumulation, goblet cell hyperplasia, and airway hyperresponsiveness. The effect of infection on the development of specific features of AAD depended on the timing of infection relative to allergic sensitisation and challenge. Infection induced significant increases in regulatory T-cell (Treg) numbers in lymph nodes, which correlated with the degree of suppression of AAD. Tregs reduced T-cell proliferation and Th2 cytokine release. The suppressive effects of infection were reversed by anti-CD25 treatment.Respiratory infection or treatment with S. pneumoniae attenuates allergic immune responses and suppresses AAD. These effects may be mediated by S. pneumoniae-induced Tregs. This identifies the potential for the development of therapeutic agents for asthma from S. pneumoniae.

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Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

Cited by 99 publications

References 55 publications

Importance of Mast Cell Prss31/Transmembrane Tryptase/Tryptase-γ in Lung Function and Experimental Chronic Obstructive Pulmonary Disease and Colitis

Importance of Mast Cell Prss31/Transmembrane Tryptase/Tryptase-γ in Lung Function and Experimental Chronic Obstructive Pulmonary Disease and Colitis

Role of dendritic cells: a step forward for the hygiene hypothesis

Streptococcus pneumoniaeinfection suppresses allergic airways disease by inducing regulatory T-cells

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