Early-life social experiences in mice affect emotional behaviour and hypothalamic-pituitary-adrenal axis function

Ros-Simó, Clara; Valverde, Olga

doi:10.1016/j.pbb.2012.06.001

Cited by 59 publications

(33 citation statements)

References 51 publications

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“…This alteration in adult glucocorticoid production was documented more than 2-months following the adolescent social experience suggesting that there was a long-term recalibration of adrenocortical activity. Similar findings of adult hypothalamic-pituitary-adrenal (HPA) hyporeactivity have been documented in humans and rodents that experienced more severe physical and social stressors during adolescence or adulthood (e.g., four to six weeks of exposure to immobilization, change of cage mate, cage tilt, exposure to white noise, exposure to predator odor; Bazak et al, 2009; Goliszek et al, 1996; Toth et al, 2008; Schmidt et al, 2007; Engert et al, 2010; Rós-Simo & Valverde, 2012; Ostrander et al, 2006). Fries, Hesse, Hellhammer, and Hellhammer (2005) proposed that chronic stress exposure may lead to an initial period of glucocorticoid hypersecretion followed by subsequent HPA hypoactivity.…”

Section: Discussionsupporting

confidence: 57%

“…For example, in rodents, adolescent chronic social stress (isolation, social reorganization, subordination during PND 28-70+) causes protracted corticosterone (CORT) responses and elevated basal CORT levels in adulthood and these effects can be prevented by anti-depressant (paroxetine) or corticotropin-releasing hormone 1 receptor antagonist (DMP696) administration during the stress procedure (Schmidt et al, 2007; Sterlemann et al, 2008; Ros-Simó & Valverde, 2012; Toth, Mikics, Tulogdi, Aliczki, & Haller, 2011). However, models of adolescent stress are highly variable (e.g.…”

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confidence: 99%

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Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats

Caruso

McClintock

Cavigelli

2014

Hormones and Behavior

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Adolescence is a period of significant behavioral and physiological maturation, particularly related to stress responses. Animal studies that have tested the influence of adolescent social experiences on stress-related behavioral and physiological development have led to complex results. We used a rodent model of neophobia to test the hypothesis that the influence of adolescent social experience on adult behavior and adrenocortical function is modulated by preadolescent temperament. Exploratory activity was assessed in 53 male Sprague-Dawley rats to classify temperament and then they were housed in one of three conditions during postnatal days (PND) 28-46: (1) with familiar kin, (2) with novel social partners, or (3) individually with no social partners. Effects on adult adrenocortical function were evaluated from fecal samples collected while rats were individually-housed and exposed to a 1-hour novel social challenge during PND 110-114. Adolescent-housing with novel or no social partners led to reduced adult glucocorticoid production compared to adolescent-housing with familiar littermates. Additionally, highly-exploratory pre-weanling rats that were housed with novel social partners during adolescence exhibited increased exploratory behavior and a more rapid return to basal glucocorticoid production in adulthood compared to those housed with familiar or no social partners during adolescence and compared to low-exploratory rats exposed to novel social partners. In sum, relatively short-term adolescent social experiences can cause transient changes in temperament and potentially longer-term changes in recovery of glucocorticoid production in response to adult social challenges. Furthermore, early temperament may modulate the influence of adolescent experiences on adult behavioral and adrenocortical function.

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Section: Discussionsupporting

confidence: 57%

mentioning

confidence: 99%

Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats

Caruso

McClintock

Cavigelli

2014

Hormones and Behavior

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“…Such effects are seen in both males and females (Craft et al , 2005; Venna et al , 2012). The mechanism by which social interaction influences ischemic outcomes is complex and involves altered neuroendocrine (Ros-Simo & Valverde, 2012; Stuller et al , 2012; Liu et al , 2013), inflammatory (Karelina et al , 2009a; Karelina et al , 2009b; Venna et al , 2012), pro-survival growth factors (Berton et al , 2006; Zhu et al , 2006; O'Keefe et al , 2014; Venna et al , 2014), cell proliferation, neurogenesis (Stranahan et al , 2006; Kannangara et al , 2011; Venna et al , 2014) and synaptic plasticity (Fone & Porkess, 2008). In addition, social stress can also affect stroke outcome.…”

Section: Psychosocial Factors Influencing Stroke Outcomementioning

confidence: 99%

Role of social factors on cell death, cerebral plasticity and recovery after stroke

Venna

McCullough

2014

Metab Brain Dis

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Stroke is a serious global health care problem. It is now is the fourth leading cause of death and the primary cause of adult disability in the United States. Substantial evidence from both experimental and clinical studies has demonstrated that social isolation (SI) can increase stroke incidence and impair recovery. Epidemiological studies demonstrate that an increasing number of patients are living alone, and as the aging population increases, loneliness will only increase in prevalence. SI is increasingly identified as an independent risk factor for all-cause mortality. In contrast, individuals with high levels of social support exhibit more rapid and extensive functional and cognitive recovery after a wide variety of pathological insults, including stroke. Clinical data suggests that SI is an important risk factor for increased mortality and delayed functional recovery following ischemic stroke. Attesting to the importance of mortality and behavioral factors in stroke outcome is that these same effects can be reproduced in animal models of experimental stroke. This has allowed researchers to identify several mechanistic changes that occur with affiliative interactions. These include decreased systemic inflammation, elaboration of growth factors including brain derived neurotropic factor (BDNF), enhanced neurogenesis, and improved neuroimmune responsiveness in group housed animals. These may mediate the beneficial effects of social interaction on improving stroke recovery and reducing neuronal death. In this review we provide an overview of the effects of SI on ischemic injury and recovery and discuss their clinical and therapeutic implications.

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“…Studies of rodents have shown that maternal licking and grooming alter the glucocorticoid receptor gene expression in the brain, lowering the corticosterone (rodents' equivalent to cortisol) reactivity [9]. On the other hand, social isolation, increases the corticosterone reactivity in mice [10]. It has been suggested that environmental factors, such as spending time together and sharing the same environment, can enhance a concordance between the mother's and the infant's cortisol levels [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A randomised trial of continuous skin-to-skin contact after preterm birth and the effects on salivary cortisol, parental stress, depression, and breastfeeding

Mörelius

Örtenstrand

Theodorsson

et al. 2015

Early Human Development

197

199

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randomised trial of continuous skin-to-skin contact after preterm birth and the effects on salivary cortisol, parental stress, depression, and breastfeeding, 2015, Early Human Development, (91) Ainsworth's sensitivity scale was used to control for parental sensitivity.Subjects: Thirty-seven families from two different neonatal care units in Sweden, randomised to either almost continuous SSC or standard care (SC).Results: Infants randomised to SSC had a lower salivary cortisol reactivity at one month (p=0.01). There was a correlation between the mothers' and the preterm infants' salivary cortisol levels at four months in the SSC group (ρ=0.65, p=0.005), but not in the SC group (ρ=0.14, p=0.63). Fathers in SSC scored lower on the SPSQ sub-scale spouse relationship problems compared to fathers in SC (p<0.05).Conclusions: Almost continuous SSC decreases infants' cortisol reactivity in response to handling, improves the concordance between mothers' and infants' salivary cortisol levels, and decreases fathers' experiences of spouse relationship problems.

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Early-life social experiences in mice affect emotional behaviour and hypothalamic-pituitary-adrenal axis function

Cited by 59 publications

References 51 publications

Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats

Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats

Role of social factors on cell death, cerebral plasticity and recovery after stroke

A randomised trial of continuous skin-to-skin contact after preterm birth and the effects on salivary cortisol, parental stress, depression, and breastfeeding

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