Early Life Stress and Inherited Variation in Monkey Hippocampal Volumes

Lyons, David M.; Yang, Chuan; Sawyer-Glover, Anne M.; Moseley, Michael E.; Schatzberg, Alan F.

doi:10.1001/archpsyc.58.12.1145

Cited by 122 publications

(83 citation statements)

References 60 publications

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“…Hippocampal volumes in the young adult monkeys did not differ significantly with respect to prior postnatal treatment-related differences in plasma cortisol levels at weaning (15). However, in keeping with studies of humans (16,17), significant heritabilities were discerned in monkeys by paternal half-sibling analysis of left and right hippocampal volumes considered separately or combined (15).…”

Section: Introductionsupporting

confidence: 58%

“…However, in keeping with studies of humans (16,17), significant heritabilities were discerned in monkeys by paternal half-sibling analysis of left and right hippocampal volumes considered separately or combined (15). Here we investigate in the same monkeys whether these hippocampal measures predict subsequent post-stress levels of adrenocorticotropic hormone (ACTH) after pretreatment with saline or hydrocortisone.…”

Section: Introductionmentioning

confidence: 78%

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Preliminary Evidence That Hippocampal Volumes in Monkeys Predict Stress Levels of Adrenocorticotropic Hormone

Lyons

Parker

Zeitzer

et al. 2007

Biological Psychiatry

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Section: Introductionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 78%

Preliminary Evidence That Hippocampal Volumes in Monkeys Predict Stress Levels of Adrenocorticotropic Hormone

Lyons

Parker

Zeitzer

et al. 2007

Biological Psychiatry

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“…The pathogenesis of hippocampal volume reduction seems to overlap with depressive pathophysiology, given its association with early-life stress, stress hormones, and duration of depressive illness (McEwen, 1999;Brunson et al, 2001;MacQueen et al, 2003). A study in monkeys suggests that hippocampal volume also reflects an inherited characteristic of the brain associated with increased cortisol response to stress (Lyons et al, 2001). Preliminary results on the genetics of the hippocampal function suggest that the BDNF val66met polymorphism may influence the development of memory deficits associated with psychopathology , and targeted disruption of mineralocorticoid receptor (MR) genes resulted in impaired hippocampal neurogenesis (Gass et al, 2000).…”

Section: Functional Imagingmentioning

confidence: 99%

Discovering Endophenotypes for Major Depression

Hasler

Drevets

Manji

et al. 2004

Neuropsychopharmacol

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The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow definitions of putative psychopathological endophenotypes: mood bias toward negative emotions, impaired reward function, impaired learning and memory, neurovegetative signs, impaired diurnal variation, impaired executive cognitive function, psychomotor change, and increased stress sensitivity. A review of the recent literature on neurobiological and genetic findings associated with these components is given. Second, the most consistent heritable biological markers of major depression are proposed as biological endophenotypes for genetic studies: REM sleep abnormalities, functional and structural brain abnormalities, dysfunctions in serotonergic, catecholaminergic, hypothalamic-pituitary-adrenocortical axis, and CRH systems, and intracellular signal transduction endophenotypes. The associations among the psychopathological and biological endophenotypes are discussed with respect to specificity, temporal stability, heritability, familiality, and clinical and biological plausibility. Finally, the case is made for the development of a new classification system in order to reduce the heterogeneity of depression representing a major impediment to elucidating the genetic and neurobiological basis of this common, severe, and often life-threatening illness.

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“…Animal models have played an important role in developing the two major theories in the field, namely that stress-related hypercortisolemia causes hippocampal atrophy (McEwen, 2000) and that hippocampal volume is heritable and a cause of, rather than a result of, increased stress susceptibility (Lyons et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Anxiety and Hippocampus Volume in the Rat

Kalisch

Schubert

Jacob

et al. 2005

Neuropsychopharmacol

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In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal volume and trait anxiety further. Magnetic resonance imaging at 7 T was used to measure hippocampal volumes in a rat model of extremes in trait anxiety (experiment 1) and in a Wistar population with normal anxiety-related behavior (experiment 2). In addition to anxiety-related behavior, potentially confounding factors (depression-like, exploratory, and locomotor behavior) were assessed. Experiment 1 globally supported the hypothesis of a positive relationship between hippocampus volume and trait anxiety but did not allow for ruling out possible confounds arising from cosegregation of other behavioral traits. Experiment 2 yielded strong evidence for a negative relationship which was specific for trait anxiety. Thus, the relationship between hippocampal volume and anxiety may be more complex than expected. Interestingly, anxietyrelated behavior in experiment 2 had a stronger influence on hippocampal volume than depression-like behavior. In the light of hippocampal volume loss in anxiety disorder and frequent comorbidity of anxiety and depression, this finding suggests that further research into the relationship between anxiety and hippocampal volume may be critical for understanding hippocampal contributions to normal and pathological behavior. Neuropsychopharmacology (2006) 31, 925-932.

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Early Life Stress and Inherited Variation in Monkey Hippocampal Volumes

Cited by 122 publications

References 60 publications

Preliminary Evidence That Hippocampal Volumes in Monkeys Predict Stress Levels of Adrenocorticotropic Hormone

Preliminary Evidence That Hippocampal Volumes in Monkeys Predict Stress Levels of Adrenocorticotropic Hormone

Discovering Endophenotypes for Major Depression

Anxiety and Hippocampus Volume in the Rat

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