Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats

Cowan, Caitlin S. M.; Stylianakis, Anthea A.; Richardson, Rick

doi:10.1016/j.dcn.2019.100627

Cited by 55 publications

(46 citation statements)

References 72 publications

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“…Similar findings were reported in the case of Wistar rats with regard to the conditioned defensive burying test (Messaoudi et al, 2011). In addition, Lactobacillus rhamnosus and Lactobacillus helveticus strains reversed the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant Sprague Dawley rats (Cowan et al, 2019). The purpose of our study was to analyze the behavioral and biochemical effects of chronic oral administration of a probiotic mixture (M) of Lactobacillus helveticus LA 102, Bifidobacterium longum LA 101, Lactococcus lactis LA 103, and Streptococcus thermophilus LA 104 (Lactibiane Référence R , PiLeJe Laboratoire, France) in two experimental models of anxiety and depression.…”

Section: Introductionsupporting

confidence: 83%

A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats

Dauge

Philippe

Mariadassou

et al. 2020

Front. Behav. Neurosci.

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Section: Introductionsupporting

confidence: 83%

A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats

Dauge

Philippe

Mariadassou

et al. 2020

Front. Behav. Neurosci.

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“… 35 This question must be studied in animal models to investigate the potential impact of specific bacteria or microbiota profiles on long-term neurodevelopment in newborns. 36 …”

Section: Discussionmentioning

confidence: 99%

Assessment of Neonatal Intensive Care Unit Practices and Preterm Newborn Gut Microbiota and 2-Year Neurodevelopmental Outcomes

et al. 2020

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Key Points Question What are the long-term outcomes associated with dysbiosis of gut microbiota in very preterm newborns? Findings In this cohort study of 577 very preterm newborns across 24 neonatal intensive care units from a French nationwide cohort, gut microbiota at week 4 after birth showed 6 bacterial patterns that varied according to gestational age, perinatal characteristics, individual treatments, and neonatal intensive care unit strategies. Three clusters were associated with 2-year outcomes after adjustment for these confounders. Meaning Modifying strategies associated with alterations in microbiota, such as promoting enteral nutrition, reducing sedation use, promoting early extubation, or skin-to-skin practice, may be correlated with outcomes in preterm newborns.

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“…Microbiota composition during the developmental period is shaped by a combination of genetic and environmental factors to be highly adapted to the host and the host’s environment 12 . However, maladaptation of the gut microbiota could affect key innate and adaptative immune signalling within the intestine and at sites anatomically remote such as the brain resulting in altered host response to infection and vaccination as well as increase the susceptibility to brain disorders 2 , 13 . For example, altered gut microbiota composition can immediately affect brain function by impacting the turnover and release of neurotransmitters, hormones as well as growth factors and consequently affect behavioural parameters and thereby increase the susceptibility to develop neuropsychiatric disorders 5 , 14 – 17 .…”

Section: Introductionmentioning

confidence: 99%

Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period

et al. 2020

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The gut microbiota is an essential regulator of many aspects of host physiology. Disruption of gut microbial communities affects gut-brain communication which ultimately can manifest as changes in brain function and behaviour. Transient changes in gut microbial composition can be induced by various intrinsic and extrinsic factors, however, it is possible that enduring shifts in the microbiota composition can be achieved by perturbation at a timepoint when the gut microbiota has not fully matured or is generally unstable, such as during early life or ageing. In this study, we investigated the effects of 3-week microbiota depletion with antibiotic treatment during the adolescent period and in adulthood. Following a washout period to restore the gut microbiota, behavioural and molecular hallmarks of gut-brain communication were investigated. Our data revealed that transient microbiota depletion had long-lasting effects on microbiota composition and increased anxiety-like behaviour in mice exposed to antibiotic treatment during adolescence but not in adulthood. Similarly, gene expression in the amygdala was more severely affected in mice treated during adolescence. Taken together these data highlight the vulnerability of the gut microbiota during the critical adolescent period and the long-lasting impact manipulations of the microbiota can have on gene expression and behaviour in adulthood.

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Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats

Cited by 55 publications

References 72 publications

A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats

A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats

Assessment of Neonatal Intensive Care Unit Practices and Preterm Newborn Gut Microbiota and 2-Year Neurodevelopmental Outcomes

Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period

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