Abstract:Violent behavior is an aberrant form of aggression that has detrimental impact on health and society. Early life trauma triggers adulthood violence and criminality, though molecular mechanisms remain elusive. Here, we provide brain region specific transcriptome profiles of peripubertal stress (PPS) exposed adult violent male and resilient female mice. We identify transthyretin (TTR) as a key regulator of PPS induced violent behavior and its intergenerational inheritance. TTR mediated long-term perturbation in … Show more
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