2016
DOI: 10.1002/ana.24803
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Early lipofuscin accumulation in frontal lobe epilepsy

Abstract: Objective: This study reports on a novel brain pathology in young patients with frontal lobe epilepsy (FLE) that is distinct from focal cortical dysplasia (FCD). Methods: Surgical specimens from 20 young adults with FLE (mean age, 30 years) were investigated with histological/immunohistochemical markers for cortical laminar architecture, mammalian target of (mTOR) pathway activation and inhibition, cellular autophagy, and synaptic vesicle-mediated trafficking as well as proteomics analysis. Findings were corre… Show more

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Cited by 15 publications
(22 citation statements)
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“…Lipofuscin accumulation has also been linked with neuronal loss in normal aging process [56]. Excessive accumulation of lipofuscin ultimately decrease cellular adaptability and promote the development of age-related pathologies, viz., Alzheimer's disease, heart failure, frontal lobe epilepsy, and age-related macular degeneration [9,[57][58][59][60][61]. In addition, this higher age-related accumulation of lipofuscin could stimulate release of inflammatory chemokines and cytokines, which in turn lead to the activation of macrophage and microglia, and subsequently cause chronic inflammatory process [62].…”
Section: Discussionmentioning
confidence: 99%
“…Lipofuscin accumulation has also been linked with neuronal loss in normal aging process [56]. Excessive accumulation of lipofuscin ultimately decrease cellular adaptability and promote the development of age-related pathologies, viz., Alzheimer's disease, heart failure, frontal lobe epilepsy, and age-related macular degeneration [9,[57][58][59][60][61]. In addition, this higher age-related accumulation of lipofuscin could stimulate release of inflammatory chemokines and cytokines, which in turn lead to the activation of macrophage and microglia, and subsequently cause chronic inflammatory process [62].…”
Section: Discussionmentioning
confidence: 99%
“…In focal epilepsy pathologies, including cortical malformations as focal cortical dysplasia , tau and p62 have been demonstrated in young adults and premature activation of neurodegenerative pathways observed in glioneuronal tumours . In a frontal lobe epilepsy series, abnormalities of neuronal autophagy and protein accumulation have been recently shown in the seizure onset zone . These observations suggest enhanced susceptibility to neurodegenerative processes in focal epilepsies.…”
Section: Neurodegenerative Processes In Hippocampal Sclerosismentioning
confidence: 94%
“…In previous studies, only a few analyzed the proteomics of epilepsy patients using brain tissues or cerebrospinal fluid [ 5 , 6 , 7 ]. However, the proteomics or transcriptomics of CCD with epilepsy has not been analyzed, especially in brain tissues of CCD patients.…”
Section: Introductionmentioning
confidence: 99%