Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects

Chao, Shih Chun; Yang, Shang Jung; Chen, Hung-Chi; Sun, Chi; Liu, Chin Hsin; Lee, Chia-Yi

doi:10.1155/2019/7419470

Cited by 30 publications

(42 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The NTG group also had a larger foveal avascular zone than did the OHT group. No difference in choriocapillaris perfusion was observed among the groups 18 . The results of our research are in agreement with the above studies.…”

Section: Discussionmentioning

confidence: 73%

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

Žáková

Lešták

Fus

et al. 2021

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Background. Hypertensive glaucoma (HTG) causes damage to the retinal ganglion cells and eventually to the entire visual pathway due to high intraocular pressure (IOP). However, increased IOP will also affect the vessel density (VD) of the posterior pole of the eye and the related retinal ganglion nerve fibres (RNFL). In normotensive glaucoma (NTG), the retinal ganglion cells are relatively intact. The pathology is at the level of ganglion fibres. The unanswered question is what has altered ganglion cell fibres at the level of the retina and optic nerve head in NTG? Aim. The aim of this study was to determine whether there is a correlation between the retinal nerve fibre layer (RNFL) and vessel density (VD) at the same altitudinal half of the retina and the sum of sensitivities of the contralateral half of the visual field of the same eye in hypertensive and normotensive glaucoma (NTG). Methods. Our group included 20 patients with HTG and 20 patients with NTG. The Pearson's correlation coefficient r was used for evaluation of the relationship of the peripapillary RNFL and VD, visual field (using the fast threshold glaucoma program) as the sum of sensitivities in apostilbs (asb) to the extent of 0-22 degrees. The results of sensitivity were compared with the RNFL and VD of the contralateral altitudinal half of the retina in the same eye. Results. In the HTG group there was a moderate relationship between RNFL and VD (both hemifields), but no relationship between RNFL and VF. VD SH and VF IH showed weak correlation and VD IH and VF SH showed no correlation. In patients with NTG, we found a strong correlation between RNFL and VD (both hemifields), between VD SH and VF IH a moderate correlation, between VD IH and VF SH also a moderate correlation and a weak correlation between RNFL and VF. Conclusion. By comparing the RNFL and VD at the same altitudinal halves of the retina, we found a moderate correlation in HTG and a strong correlation in NTG. We found no or a weak correlation between VD and VF in HTG. In NTG the relationship between VD and VF showed a strong correlation. These findings reveal the differences in the diagnostic groups.

show abstract

Section: Discussionmentioning

confidence: 73%

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

Žáková

Lešták

Fus

et al. 2021

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

show abstract

“…[14][15][16][17] In addition, Shoji et al 18 find that superficial macula VD led to a faster loss in POAG eyes than in healthy eyes. Chao et al 19 and Shin et al 20 report that NTG groups have lower superficial and deep VD when compared with healthy eyes.…”

Section: Discussionmentioning

confidence: 98%

Correlation of Visual Field With Peripapillary Vessel Density Through Optical Coherence Tomography Angiography in Normal-Tension Glaucoma

Lin

Huang

Yeung

et al. 2020

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose To investigate the retinal vessel density (VD) in healthy and normal-tension glaucoma (NTG) eyes through optical coherence tomography angiography (OCTA) and to determine the correlation between VD and the retinal nerve fiber layer (RNFL) thickness and functional visual field (VF) defects for different locations. Methods A total of 74 NTG eyes and 24 healthy eyes were included. OCTA VD at 4.5 × 4.5 mm peripapillary region and 3.0 × 3.0 mm macula area, RNFL thickness, and VF pattern deviation results were individually analyzed on the basis of the Garway-Heath sectorization. Correlations between VD and VF/RNFL and VF were compared. Results In the NTG group, peripapillary VD, superficial macula VD, RNFL thickness, and ganglion cell complex thickness were significantly lower. In the whole peripapillary area and inferotemporal sector, anatomic correlations between VD and VF pattern deviation values were significantly higher than those between the RNFL thickness and VF values. In the subgroup analysis, VD was anatomically correlated with VF in early-, moderate-, and severe-stage NTG eyes, whereas the RNFL thickness was correlated with VF in moderate- and severe-stage NTG eyes. Conclusions We observed VD reduction in the peripapillary retina and superficial macula area in NTG eyes. The microvascular dropout of VD in the peripapillary retina, especially in the inferotemporal sector, provided a more accurate anatomic correlation with functional VF defects than that of the RNFL thickness, especially in early-stage NTG eyes. Translational Relevance In patients who cannot comply VF exam, VD is a good tool for disease detection.

show abstract

“…The nailfold capillary is easily affected by external factors, like temperature, and more susceptible to trauma. On the contrary, retinal microcirculation could be affected by IOP, axial length, refractive error, and changes in the thickness and function of RNFL as well as ganglion cells ( Yu et al, 2014 ; Shiihara et al, 2018 ; Chao et al, 2019 ). However, the OCTA is more objective.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Tian

Xie

et al. 2020

Front. Physiol.

View full text Add to dashboard Cite

Objective To evaluate whether the nailfold microcirculation is associated with retinal microcirculation in healthy subjects. Methods Fifty subjects without systematic and ocular diseases were enrolled. Thickness of peripapillary retinal nerve fiber layer (RNFL), vessel density (VD) of radial peripapillary capillaries (RPCs), and superficial capillary VD in macular zone were measured with optical coherence tomography angiography (OCTA) in left eyes. Nailfold microcirculation, including capillary density, avascular zones, dilated capillaries, and hemorrhages was examined on the fourth digit of each subject’s non-dominant (left) hand with nailfold capillaroscopy (NFC). Results After adjustment for relatively systemic factors, multivariate regression analyses showed a significant direct relationship between RNFL thickness and nailfold capillary density (OR = 1.09; p = 0.046). RNFL thickness and RPCs VD were negatively correlated with nailfold avascular zones (OR = 0.855; p = 0.007; OR = 0.596; p = 0.010). Superficial VD of parafovea was negatively associated with dilated nailfold capillaries (OR = 0.794; p = 0.012). Conclusion In healthy subjects, nailfold capillary lower density and abnormalities are associated with reduced RNFL thickness and retinal VD. The results provide a theoretical foundation for relevant studies on ocular diseases with microvascular abnormalities and could contribute to pathogenesis understanding in the future. NFC and OCTA have the potential to identify risk factors and improve accuracy of the early diagnosis and treatment of ocular diseases, even systemic diseases with any microvascular component in clinical practice. Clinical Trail Registration http://www.chictr.org.cn/index.aspx , identifier ChiCTR 1800017875.

show abstract

Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects

Cited by 30 publications

References 35 publications

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

Correlation of Visual Field With Peripapillary Vessel Density Through Optical Coherence Tomography Angiography in Normal-Tension Glaucoma

The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Contact Info

Product

Resources

About