Early malignant syphilis

Ortigosa, Yara Martins; Bendazzoli, Paulo Salomão; Barbosa, Angela Marques; Ortigosa, Luciena Cegatto Martins

doi:10.1590/abd1806-4841.20164491

Cited by 16 publications

(25 citation statements)

References 7 publications

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“…It was a common diagnosis in the 1700s, and usually seen in cachectic patients with tuberculosis. Its unusual clinical manifestation appears to be related to poor health condition, malnutrition, and inappropriate use of immunosuppressants or antibiotics [6] . More cases have been seen recently in people with HIV infection than previously.…”

Section: Discussionmentioning

confidence: 99%

Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient

Lopes

Monteiro

Saez

et al. 2023

European Journal of Case Reports in Internal Medicine

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Early malignant syphilis is an uncommon form of secondary syphilis and characterized by pleomorphic multiple round-to-oval papules, some with necrosis, and associated with systemic signs and symptoms. Usually seen in immunosuppressed patients, mainly those infected with HIV, it can also be observed in immunocompetent patients. We report a case in a young healthy woman with the characteristic features of the disease and with favourable skin lesion evolution after appropriate treatment with penicillin.

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Section: Discussionmentioning

confidence: 99%

Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient

Lopes

Monteiro

Saez

et al. 2023

European Journal of Case Reports in Internal Medicine

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“…Malignant syphilis, or lues maligna, is a severe form of secondary syphilis that presents as an ulcerative predominant erythroderma. 4 Malignant syphilis was commonly observed in the seventeenth century prior to the development of antibiotics, 5 and has recently re-emerged with the HIV epidemic. In up to 30% of cases of erythroderma, a clear etiology is not identified.…”

Section: Discussionmentioning

confidence: 99%

An Elusive Case of Mycosis Fungoides: Case Report and Review of the Literature

et al. 2019

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Erythroderma refers to a spectrum of skin diseases resulting in diffuse erythema and scaling encompassing ≥ 90% of the body surface area. The differential diagnosis ranges from primary dermatologic diseases such as atopic dermatitis and psoriasis to potentially deadly causes such as staphylococcal toxic shock syndrome, toxic epidermal necrolysis, and malignancy. Cutaneous T cell lymphoma (CTCL) is an uncommon but highly morbid cause of erythroderma. This non-Hodgkin lymphoma remains a diagnostic challenge due to its variable clinical presentation and varied histologic features. Mycosis fungoides (MF) is the most common form of CTCL. Making a timely diagnosis is challenging as it may mimic inflammatory diseases of the skin including eczema, psoriasis, lichen planus, and cutaneous lupus. We present a case of a 58year-old man who presented with 5 years of cutaneous symptoms and several months of fevers and night sweats, ultimately diagnosed as MF. Owing to diffuse CD30 positivity, he was a candidate for brentuximab vedotin, an antibody-drug conjugate medication that selectively targets the CD30 antigen. This resulted in an excellent therapeutic response.

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“…The risk of malignant syphilis has been associated with HIV and other types of immunosuppressed conditions such as severe malnutrition, chronic alcoholism, and diabetes mellitus. 2,3 E. Hematologic malignancies eIncorrect. Hematologic malignancies are more associated with disseminated herpes zoster infection.…”

Section: Dmentioning

confidence: 99%

Ulcerative nodules on the entire body

2020

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A 58-year-old man with diabetes mellitus presented with a 1-month history of nodules on his entire body. He had loss of appetite, myalgia, and fever soon followed by the onset of nodules that progressed to ulcers. Physical examination found nonpruritic, painless, multiple, variable-sized, erythematous, ulcerative nodules with central crusts on his face, trunk, and extremities (Fig 1). A biopsy specimen of the lesion was obtained (Fig 2), which showed an acanthotic epidermis and intense lichenoid lymphohistiocytic infiltrate rich in plasma cells in the dermis and extended around vessels. Question 1. What is the most likely diagnosis? A. Kyrle disease B. Pyoderma gangrenosum C. Malignant syphilis D. Febrile ulceronecrotic Mucha-Habermann disease E. Disseminated herpes zoster

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Early malignant syphilis

Cited by 16 publications

References 7 publications

Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient

Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient

An Elusive Case of Mycosis Fungoides: Case Report and Review of the Literature

Ulcerative nodules on the entire body

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