Early maternal age at first birth is associated with chronic diseases and poor physical performance in older age: cross-sectional analysis from the International Mobility in Aging Study

Pirkle, Catherine M; Sousa, Ana Carolina Patrício de Albuquerque; Alvarado, Beatriz; Zunzunegui, Marı́a Victoria

doi:10.1186/1471-2458-14-293

Cited by 94 publications

(105 citation statements)

References 60 publications

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“…Studies of age at childbearing are consistent in showing poorer later health and higher mortality among women with an early entry to motherhood (Kalil and Kunz 2002;Grundy and Tomassini 2005;Mirowsky 2005;Henretta 2007;Henretta et al 2008;Patel and Sen 2012;Pirkle et al 2014), although some studies indicate a different association among Black women in the USA (Spence and Eberstein 2009). Later health disadvantages of early fatherhood have also been reported (Grundy and Tomassini 2006;Grundy and Kravdal 2008;Pudrovska and Carr 2009).…”

Section: Age At Parenthoodmentioning

confidence: 98%

Pathways from fertility history to later life health: Results from analyses of the English Longitudinal Study of Ageing

Grundy¹,

Read²

2015

DemRes

127

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BACKGROUNDPrevious research shows associations between fertility histories and later life health. The childless, those with large families, and those with a young age at entry to parenthood generally have higher mortality and worse health than parents of two or three children. These associations are hypothesised to reflect a range of biosocial influences, but underlying mechanisms are poorly understood. OBJECTIVESTo identify pathways from fertility histories to later life health by examining mediation through health-related behaviours, social support and strain, and wealth. Additionally to examine mediation through allostatic load -an indicator of multisystem physical dysregulation, hypothesised to be an outcome of chronic stress. METHODSAssociations between fertility histories, mediators, and outcomes were analysed using path models. Data were drawn from the English Longitudinal Study of Ageing. Outcomes studied were a measure of allostatic load based on 9 biomarkers and selfreported long-term illness which limited activities. RESULTSEarly parenthood (<20 for women, <23 for men) was positively associated with higher (worse) allostatic load and long-term illness. These associations were partly mediated through wealth, smoking, and physical activity. Wealth, smoking, physical activity, and social strain also mediated associations between larger family size, itself associated with early parenthood, and health outcomes. We found no significant associations between childlessness and allostatic load or long-term illness, except for an association

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Section: Age At Parenthoodmentioning

confidence: 98%

Pathways from fertility history to later life health: Results from analyses of the English Longitudinal Study of Ageing

Grundy¹,

Read²

2015

DemRes

127

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“…Yet, AFB may confound observed associations between parity and CVD, because AFB is closely linked with parity . Women with early AFB tend to have more children . For example, in 1 study of middle‐aged women from Brazil, those who gave birth as adolescents were twice as likely to have ≥3 children across their lifetimes compared with women whose first childbirth was during adulthood …”

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confidence: 99%

Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)

Rosendaal

Alvarado

et al. 2017

JAHA

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BackgroundPrevious studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB). Herein, we examine the association of AFB with a summary cardiovascular risk measure (Framingham Risk Score [FRS]).Methods and ResultsAs part of the IMIAS (International Mobility in Aging Study), data were collected in 2012 among 1047 women, aged 65 to 74 years, from Canada, Albania, Colombia, and Brazil. FRSs were calculated to describe cardiovascular risk profiles, and linear regression analyses were performed, adjusting for early life and socioeconomic variables. Women with an AFB of <20 years were compared with women with an AFB of 20 to 24, 25 to 29, and ≥30 years, as well as nulliparous women. We also compared FRS between combinations of AFB and parity categories: nulliparous women, parity 1 to 3 combined with AFB <20 years, parity ≥4 with AFB <20 years, parity 1 to 3 with AFB ≥20 years, and parity ≥4 with AFB ≥20 years. Women with an AFB of <20 years had a higher mean FRS compared with all other AFB groups. Compared with the lowest AFB risk group (25–29 years), women with an AFB of <20 years had a 5.8‐point higher mean FRS (95% confidence interval, 3.4–8.3 points). Nulliparous women presented the lowest mean FRS in all analyses. The analysis comparing combinations of AFB and parity categories showed no meaningful differences in FRS between women who had 1 to 3 childbirths and those who had ≥4 childbirths within the stratum of AFB <20 years, and in the stratum of AFB ≥20 years.ConclusionsOur analyses suggest that nulliparity and AFB, rather than increasing parity, drive the association with cardiovascular disease risk.

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“…Data were collected at baseline in 2012. Details of the study design have been described elsewhere (Sousa et al 2014;Pirkle et al 2014;Zunzunegui et al 2015).…”

Section: Design and Participantsmentioning

confidence: 99%

Clinically relevant weakness in diverse populations of older adults participating in the International Mobility in Aging Study

Fernandes

Pérez‐Zepeda

Béland

et al. 2016

AGE

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The aims of this study were to compare cut points for weakness proposed by Foundation for the National Institutes of Health (FNIH) Sarcopenia Project with cut points estimated with our own data; to assess the prevalence of clinically relevant handgrip strength (HGS) weakness according to published criteria across distinct populations of older adults; to estimate the ability of HGS weakness to identify slowness. This is a cross-sectional analysis of International Mobility in Aging Study (IMIAS) involving 1935 community-dwelling older adults, between 65 and 74 years, who completed HGS and gait speed assessment. We used baseline data from Tirana (Albania), Natal (Brazil), Manizales (Colombia), Kingston (Ontario, Canada), and Saint-Hyacinthe (Quebec, Canada). Weakness was defined according to sex-specific HGS cut points associated with slowness proposed by FNIH Sarcopenia Project. Slowness was defined as gait speed <0.8 m/s. IMIAS cut points for clinical weakness had good agreement with those proposed by FNIH. Weakness prevalence across the research sites ranged from 1.1 % (Saint-Hyacinthe) to 19.2 % (Manizales) among men. Women from Manizales (13.5 %) and Natal (19.3 %) had higher prevalence of weakness than their counterparts. FNIH cut points had a strong association with slowness, for both sexes. The IMIAS population generated cut points which were close to those proposed by FNIH. There was large variability in prevalence of weakness across our research sites. The HGS cut points for weakness proposed by FNIH performed well in IMIAS populations, providing a useful tool for screening older adults at risk for functional problems.

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Early maternal age at first birth is associated with chronic diseases and poor physical performance in older age: cross-sectional analysis from the International Mobility in Aging Study

Cited by 94 publications

References 60 publications

Pathways from fertility history to later life health: Results from analyses of the English Longitudinal Study of Ageing

Pathways from fertility history to later life health: Results from analyses of the English Longitudinal Study of Ageing

Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)

Clinically relevant weakness in diverse populations of older adults participating in the International Mobility in Aging Study

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