Early Measurement of Indocyanine Green Clearance Accurately Predicts Short-Term Outcomes After Liver Transplantation

Olmedilla, Luis; Lisbona, Cristina; Pérez-Peña, Jose; López-Baena, José Ángel; Garutti, Ignacio; Salcedo, Magdalena; Sanz, Javier; Tisner, Manuel; Asencio, José Manuel; Fernández-Quero, L; Bañares, Rafael

doi:10.1097/tp.0000000000000980

Cited by 31 publications

(35 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In spite of the initial enthusiasms and some very recent results, the use of post OLT ICG kinetics to predict morbidity and mortality are to be considered, at least in our opinion, still under scrutiny. Notwithstanding the results proposed by the most recent publication [59] , mixed results or "false pathological findings" (false positives) are present in the literature: To be specifically addressed in the liver transplant setting is the presence of hyperbilirubinemia. In this context, according to ICGPDR, newly grafted liver might be falsely classified as severely dysfunctioning or at consistent risk of unfavourable outcome, when opposite is the real final outcome.…”

Section: Resultsmentioning

confidence: 96%

“…In this context, according to ICGPDR, newly grafted liver might be falsely classified as severely dysfunctioning or at consistent risk of unfavourable outcome, when opposite is the real final outcome. In spite of the most recent evidence [59] , no consensus exists on the cut-off value of PDR/R15 below which a reliable assessment of early graft dysfunction is confidently available. In liver transplanted patients, the negative predictive value of ICG kinetics is indeed relevant: Good graft and patients outcome are almost always associated with "normal" IGC clearance parameters.…”

Section: Resultsmentioning

confidence: 99%

“…In a validation cohort of 70 patients the score had a good diagnostic performance with sensitivity 60%; specificity 95.5%; positive predictive value (PPV), 66.7%; negative predictive value (NPV) 94.1%. The AAs concluded for a simple and useful tool to be considered for the selection of diagnostic and therapeutic strategies in the early postoperative period [59] . Different result were proposed by Escorsell et al [60] .…”

Section: Icg Kinetics In Liver Transplant Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Gasperi

Mazza

Prosperi

2016

WJH

150

124

View full text Add to dashboard Cite

Indocyanine green (ICG) kinetics (PDR/R15) used to quantitatively assess hepatic function in the perioperative period of major resective surgery and liver transplantation have been the object of an extensive, updated and critical review. New, non invasive bedside monitors (pulse dye densitometry technology) make this opportunity widely available in clinical practice. After having reviewed basic concepts of hepatic clearance, we analysed the most common indications ICG kinetic parameters have nowadays in clinical practice, focusing in particular on the diagnostic and prognostic role of PDR and R15 in the perioperative period of major liver surgery and liver transplantation. As recently pointed out, even if of extreme interest, ICG clearance parameters have still some limitations, to be considered when using these tests. Core tip: Non invasive monitors for indocyanine green (ICG) clearance (PDR and R15) are now available for a rapid assessment of liver function both in the intensive care unit and in major liver surgery. After having reviewed the basic concepts of hepatic clearance, we have analysed the most common indications of ICG kinetic parameters in clinical practice, focusing on the diagnostic and prognostic role of PDR and R15 in the perioperative period of major resective liver surgery and liver transplantation. Since ICG parameters have still some limitations, we will underline the conditions (mainly hyperbilirubinemia and severe peripheral hypoperfusion) able to alter the reliability of these tests.De Gasperi A, Mazza E, Prosperi M. Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? World

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Icg Kinetics In Liver Transplant Surgerymentioning

confidence: 99%

See 1 more Smart Citation

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Gasperi

Mazza

Prosperi

2016

WJH

150

124

View full text Add to dashboard Cite

show abstract

“…Despite only two of the reviewed articles included repeated measurements in the modelling process, repeated measurements of at least one of the candidate predictors were actually reported to be available in 6 (18.2%) of the articles [24,27,30,31,37,45]. Of these 6 articles that repeated measures were available, 4 of these had repeated measures that we categorised as being high risk [27,30,31,45], one of which used the repeated measures within the modelling [27].…”

Section: >> Insert Table 2: Predictors In Final Models At High Risk Omentioning

confidence: 99%

Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported

Whittle

Peat

Belcher

et al. 2018

Journal of Clinical Epidemiology

View full text Add to dashboard Cite

show abstract

“…Acceptable accuracy of the PDD system has been reported after comparing data derived from invasive and non-invasive methods [23][24][25][26][27]. These non-invasive PDD systems have made the ICG clearance test more attractive even in Western countries, and many investigators have recently reported its usefulness as a non-invasive dynamic liver function test [28][29][30][31].…”

Section: Icg Clearance Testmentioning

confidence: 99%

ICG Clearance Test and 99mTc-GSA SPECT/CT Fusion Images

Iimuro¹

2017

Visc Med

View full text Add to dashboard Cite

Preoperative estimation of future remnant liver function is critical for major hepatic surgery to avoid postoperative morbidity and mortality. Among several liver function tests, the indocyanine green (ICG) clearance test is still the most popular dynamic method. The usefulness of ICG clearance test parameters, such as ICGR15, K_ICG, or PDR_ICG, has been reported by many investigators. The transcutaneous non-invasive pulse dye densitometry system has made the ICG clearance test more convenient and attractive, even in Western countries. The concept of future remnant K_ICG (rem K_ICG), which combines the functional aspect and the volumetric factor of the future remnant liver, seems ideal for determining the maximum extent of major hepatic resection that will not cause postoperative liver failure. For damaged livers with functional heterogeneity among the hepatic segments, fusion images combining technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin single photon emission computed tomography (99mTc-GSA SPECT) and X-ray CT are helpful to precisely estimate the functional reserve of the future remnant liver. Another technique for image-based liver function estimation, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB)-enhanced magnetic resonance imaging, may be an ideal candidate for the preoperative determination of future remnant liver function. Using these methods effectively, morbidity and mortality after major hepatic resection could be reduced.

show abstract

Early Measurement of Indocyanine Green Clearance Accurately Predicts Short-Term Outcomes After Liver Transplantation

Abstract: A simple score obtained within the first day after LT predicts short-term survival and need for retransplantation and may prove useful when selecting diagnostic and therapeutic strategies.

Cited by 31 publications

References 31 publications

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery?

Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported

ICG Clearance Test and 99mTc-GSA SPECT/CT Fusion Images

Contact Info

Product

Resources

About