Early menarche is associated with metabolic syndrome and insulin resistance in premenopausal Korean women

Abstract

Early menarche (<12 years) is associated with metabolic syndrome and insulin resistance in nationally representative Korean premenopausal women. However, late menarche (>16 years) is not associated with metabolic syndrome after controlling for age and other confounders.

A Cutoff for Age at Menarche Predicting Metabolic Syndrome in Egyptian Overweight/Obese Premenopausal Women

“…This cutoff is about to be similar with that used for definition of early menarche in previous studies reporting its association with metabolic syndrome [3456]. To best of our knowledge, this is the first time to define a cutoff for age at menarche that predicts metabolic syndrome using ROC curve analysis.…”

“…Several studies showed a link between early age at menarche and increased risk of metabolic syndrome [3456]. However, the definition of early menarche at these studies either below 12 years [345] or below 12.5 years [6] was based on background data in their communities.…”

“…However, the definition of early menarche at these studies either below 12 years [345] or below 12.5 years [6] was based on background data in their communities. The aim of this work is to determine a cutoff for age at menarche predicting metabolic syndrome in premenopausal overweight/obese women.…”

Duration of reproductive lifespan and age at menarche in relation to metabolic syndrome in postmenopausal Chinese women

“…However, postmenopausal women possibly still benefit from the endogenous estrogen produced during their reproductive history, due to the effects it would have exerted on conventional cardiovascular risk factors . Among female reproductive factors, early menarche and early menopause have been identified to be associated with the risk of mortality from cardiometabolic disease in postmenopausal women . Nevertheless, there is still little knowledge about whether the duration of the reproductive lifespan could have a role in MetS risk after menopause.…”

Association between Body Weight Changes and Menstrual Irregularity: The Korea National Health and Nutrition Examination Survey 2010 to 2012

“…It was reported that there was a negative relationship between BMI and menarche age in a cohort study [25] and early menarche was associated with increased adult BMI in a meta-analysis [26]. Data have consistently shown that women with early menarche have higher risks of metabolic syndrome, type 2 diabetes and cardiovascular disease [252728]. Conversely, in our study, subjects with menstrual irregularity had a higher age of menarche (14.0±0.1) compared to subjects without menstrual irregularity (13.8±0.0).…”