Early menopause in mothers of children with Down syndrome?

Stroom, Elizabeth M.C. van der; König, T.E.; Broeder, Eline van Dulmen‐den; Elzinga, Wieteke S.; Montfrans, Joris M. van; Haadsma, Maaike L.; Lambalk, Cornelis B.

doi:10.1016/j.fertnstert.2011.07.1149

Cited by 23 publications

(5 citation statements)

References 31 publications

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“…4,24 There have been several reports that diminished ovarian reserve might lead to trisomic pregnancy. [25][26][27] Notably, van der Stroom et al reported that mothers with a Down syndrome pregnancy had serum AMH values that were significantly lower than in their age-matched controls. 26 They also suggested the possibility that a diminished follicular pool could lead to a reduction in oocytes quality due to meiotic errors.…”

Section: Discussionmentioning

confidence: 99%

“…[25][26][27] Notably, van der Stroom et al reported that mothers with a Down syndrome pregnancy had serum AMH values that were significantly lower than in their age-matched controls. 26 They also suggested the possibility that a diminished follicular pool could lead to a reduction in oocytes quality due to meiotic errors. Moreover, Li et al reported that in intrauterine insemination cycles, serum AMH remained the only significant predictor of cumulative live birth after controlling for confounders such as age and FSH.…”

Section: Discussionmentioning

confidence: 99%

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Serum Anti-Mullerian Hormone Levels Affect the Rate of Ongoing Pregnancy After In Vitro Fertilization

Honnma¹,

Baba

Sasaki³

et al. 2013

Reprod. Sci.

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We used logistic regression analysis to investigate the relationship between serum anti-Mullerian hormone (AMH) levels and the rate of ongoing pregnancy. Retrospective data were collected from 1043 women who had undergone their first cycle of in vitro fertilization (IVF), including 540 cycles of fresh embryo transfer and 503 cycles of frozen-thawed embryo transfer. The patients were divided into 4 groups based on the cutoff values from a receiver-operating characteristic curve: 0.0 to 12.4, 12.5 to 25.5, 25.6 to 44.1, and >44.2 pmol/L. After adjustment for multiple confounders, the serum AMH group was found to be significantly related to the rate of ongoing pregnancy in total cycles (0.0-12.4 vs 12.5-25.5 pmol/L; P = .0088, odds ratio, 1.909: vs 25.6-44.1 pmol/L; P = .0281, odds ratio, 2.109: vs >44.2 pmol/L; P = .0008, odds ratio, 2.840). In conclusion, there appears to be a significant relationship between serum AMH levels and the ongoing pregnancy rate in first IVF treatment cycles after adjustment for multiple confounders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Anti-Mullerian Hormone Levels Affect the Rate of Ongoing Pregnancy After In Vitro Fertilization

Honnma¹,

Baba

Sasaki³

et al. 2013

Reprod. Sci.

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“…increases in follicle stimulating hormone, FSH), incidence of trisomic conceptions and abortions have been analysed in retrospective and prospective studies. For instance, women with a trisomy 21 pregnancy at a younger age have often lower AMH levels, suggesting a correlation between aneuploid oocytes and a limited ovarian reserve (van der Stroom et al, 2011). Accordingly, younger poor responding patients (.36 years) who had presumably a reduced ovarian reserve, had a statistically significant increased miscarriage rate, possibly related to an increased aneuploidy rate, compared to normal responders (Haadsma et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Oocyte ageing and its cellular basis

Eichenlaub-Ritter

2012

Int. J. Dev. Biol.

104

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Aneuploidy is extremely high in aged human oocytes. Its cellular origin has been elusive. Trisomy data implicate predominantly meiosis I errors in the genesis of oocyte aneuploidy. Susceptible recombination patterns increase risks for nondisjunction. Cytogenetic analyses of aged human oocytes and embryos from assisted reproduction (ART) suggest that aneuploidy primarily relates to precocious chromatid separation. Oocytes express a spindle assembly checkpoint (SAC), but do not arrest maturation in the presence of improperly attached or single, unattached chromosomes. The SAC may be more permissive by altered gene expression in aged oocytes. Aged oocytes frequently exhibit precocious loss of chromosome cohesion. In experimental models, cohesion cannot be restored once lost, a process possibly occurring during long meiotic arrest. Maternal age, hormonal stimulation, disturbed metabolism, and depletion of the follicle pool contribute to mitochondrial dysfunction, spindle aberrations, and errors in chromosome segregation. Caloric restriction and antioxidants reduce mitochondrial dysfunction and aneuploidy in aged rodent's oocytes. Loss of chromosome cohesion appears to be a major risk factor for aneuploidy by disturbing the sequential separation of homologs and chromatids. A permissive SAC, the presence of risky meiotic exchanges, changes in expression, and failures to resolve improper chromosome attachments, as well as mitochondrial dysfunction may synergistically increase susceptibility to meiotic errors. A healthy life style, mild stimulation and an optimal environment may delay ageing and sustain control over chromosome disjunction, whereas loss of cohesion appears to be irreversible.

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“…A strong positive relationship between serum antim€ ullerian hormone (AMH) and the rate of euploid blastocysts was found, which was independent from maternal age (33). It was reported that women with the history of at least one trisomic fetus have a diminished ovarian reserve (34) and thus experience menopause at an earlier age (35). Furthermore, CM rates in patients displaying reduced serum AMH levels were significantly increased, which was independent from maternal age and the number of oocytes retrieved (36).…”

Section: Figurementioning

confidence: 98%

Higher chromosomal abnormality rate in blastocysts from young patients with idiopathic recurrent pregnancy loss

Fan

Wang

et al. 2020

Fertility and Sterility

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Objective: To determine whether the incidence of chromosomal abnormalities in blastocysts is higher in patients with idiopathic recurrent pregnancy loss (iRPL) who underwent preimplantation genetic testing for aneuploidy (PGT-A) than in those who underwent preimplantation genetic testing for monogenic defects (PGT-M). Design: Retrospective cohort study. Setting: University-affiliated reproductive center. Patient(s): A total of 62 patients with iRPL underwent 101 PGT-A cycles (iRPL group), and 212 patients underwent 311 PGT-M cycles (control group). Interventions(s): Blastocyst biopsy and comprehensive chromosome screening technologies, including single-nucleotide polymorphism microarrays and next-generation sequencing. Main Outcome Measure(s): Incidence of chromosomal abnormalities in blastocysts and clinical miscarriage (CM) rate.Result(s): Stratification analysis by maternal age showed an increased incidence of chromosomal abnormalities in the iRPL group aged %35 years (48.9% vs. 36.9%), whereas no significant increase was found in the iRPL group aged >35 years (66.9% vs. 61.4%). After transfer of euploid embryos, women aged %35 years with iRPL exhibited an increased CM rate compared with the control group (26.1% vs. 3.1%). Conclusion(s):Young patients with iRPL have a significantly higher rate of chromosomal abnormalities in blastocysts compared with patients with no or sporadic CM. Although euploid embryos were transferred after PGT-A, young patients with iRPL had a higher CM rate, which may indicate that chromosomal abnormalities might not be the only causal factor for iRPL. Therefore, the role of PGT-A in iRPL still needs to be clarified. (Fertil Steril Ò 2020;113:853-64. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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Early menopause in mothers of children with Down syndrome?

Cited by 23 publications

References 31 publications

Serum Anti-Mullerian Hormone Levels Affect the Rate of Ongoing Pregnancy After In Vitro Fertilization

Serum Anti-Mullerian Hormone Levels Affect the Rate of Ongoing Pregnancy After In Vitro Fertilization

Oocyte ageing and its cellular basis

Higher chromosomal abnormality rate in blastocysts from young patients with idiopathic recurrent pregnancy loss

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