Early modifications of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids

Stasi, Delia Di; Bernasconi, Roberto; Marchioli, Roberto; Marfisi, Rosa Maria; Rossi, Giovanna; Tognoni, Gianni; Tacconi, M.T.

doi:10.1007/s00228-004-0758-8

Cited by 68 publications

(63 citation statements)

References 40 publications

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“…Consistent dosing of n-3 fatty acids over long periods is also necessary to maintain the total plasma levels of EPA and DHA. Di Stasi et al (2004) previously evaluated the incorporation of n-3 PUFAs over time in human plasma and blood cells as a biomarker for other cellular membranes (such as myocytes) and determined that one gram per day of supplementation was capable of inducing significant changes in the composition of the polyunsaturated fatty acids in the blood, even after one week. This rapid uptake explains its beneficial effects against cardiovascular diseases.…”

Section: Resultsmentioning

confidence: 99%

Heart rate variability indices in the time domain in healthy dogs supplemented with omega n-3

Santos

Araújo

Gonçalves³

et al. 2014

Sem. Ci. Agr.

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The analysis of heart rate variability (HRV) in the time domain was performed by dynamic electrocardiographic monitoring for twenty-four hours (Holter method) in ten male and ten female healthy mixed-breed dogs before and after four weeks of oral supplementation with long-chain polyunsaturated fatty acids (PUFAs) derived from omega n-3 [497 mg docosahexaenoic acid (DHA) and 780 mg eicosapentaenoic acid (EPA)]. Males received an average dose of 34.9 mg DHA/kg and 22.2 mg EPA/kg, whereas females received an average of 27 mg DHA/kg and 43 mg EPA/kg. HRV indices calculated in the time domain were the following: NN, SDNN, SDANN, SDNN index, pNN50, rMSSD and heart rate, taking into account the effects of gender and supplementation. The results showed no significant effects of supplementation or gender on the indices; thus, dietary supplementation with omega PUFAs derived from n-3 over four weeks did not decrease heart rate and did not increase heart rate variability in healthy dogs. Key words: Dog, HRV, PUFAs, holter ResumoA análise da variabilidade da frequência cardíaca (VFC) no domínio do tempo, foi realizada por meio da monitorização eletrocardiográfica dinâmica em vinte e quatro horas (Holter), em cães sadios, sem raça definida, sendo dez machos e dez fêmeas, antes e após suplementação oral, por quatro semanas com ácido graxos poliinsaturados de cadeia longa (PUFAS) derivados do ômega n-3 [497 mg ácido docosahexaenóico (DHA) e 780 mg ácido eicosapentanóico (EPA)], resultando em uma dose média de 34,9 mg/kg de EPA e 22,2 mg/kg de DHA em machos e média de 43 mg/kg de EPA e 27 mg/kg em fêmeas. Os índices da VFC calculados no domínio do tempo foram: NN, SDNN, SDANN, SDNN índex, pnn50 e rMSSD e frequência cardíaca, verificando-se o efeito do sexo e da suplementação. Os resultados obtidos não demonstraram efeitos significativos da suplementação ou influência do sexo

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Section: Resultsmentioning

confidence: 99%

Heart rate variability indices in the time domain in healthy dogs supplemented with omega n-3

Santos

Araújo

Gonçalves³

et al. 2014

Sem. Ci. Agr.

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“…27 For this reason, it is likely that the incorporation of n-3 fatty acids in these cell types modifies membrane properties, such as stability and fluidity, 28 as well as cytosolic calcium concentration, protein localization and functionality in caveolae, 29 reducing cell activation and/or apoptosis, with this translating into lower MP release. Differences in the ability of various cell types to incorporate fatty acids or in their ability to respond functionally to such changes may explain the different cellular responses observed in terms of MP release.…”

Section: Ed Mp Populations In Humansmentioning

confidence: 99%

Effect of the administration of n-3 polyunsaturated fatty acids on circulating levels of microparticles in patients with a previous myocardial infarction

Turco¹,

Basta²,

Lazzerini³

et al. 2008

Haematologica

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BackgroundIncreased levels of microparticles exposing tissue factor circulate in the blood of patients with coronary heart disease, possibly disseminating their pro-thrombotic and pro-inflammatory potential. Because diets rich in n-3 (polyunsaturated) fatty acids have been associated with reduced incidence of coronary heart disease-related events, we investigated the in vivo effects of treatments with n-3 fatty acids on levels of circulating microparticles and their tissue factor-dependent procoagulant activity in patients with a previous myocardial infarction.

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“…tion of fish oil (2 g/day; EPA-E: 46%, DHA-E: 39%) for 12 weeks resulted in an increase in the platelet EPA levels; however, both the DHA and AA levels remained almost unchanged 53) . In summary, EPA administration increases the platelet EPA levels more than it decreases the platelet AA levels.…”

mentioning

confidence: 96%

Eicosapentaenoic Acid (EPA) Reduces Cardiovascular Events: Relationship with the EPA/Arachidonic Acid Ratio

Ohnishi

Saitō

2013

JAT

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The clinical efficacy of fish oil and high-purity eicosapentaenoic acid ethyl ester (hp-EPA-E) for treating cardiovascular disease (CVD) has been reported. Fish oil contains saturated and monounsaturated fatty acids that have pharmacological effects opposite to those of ω3 fatty acids (ω3). Moreover, ω3, such as EPA and docosahexaenoic acid (DHA), do not necessarily have the same metabolic and biological actions. This has obscured the clinical efficacy of ω3. Recently, the Japan EPA Lipid Intervention Study (JELIS) of hp-EPA-E established the clinical efficacy of EPA for CVD, and higher levels of blood EPA, not DHA, were found to be associated with a lower incidence of major coronary events. A significant reduction in the risk of coronary events was observed when the ratio of EPA to arachidonic acid (AA) (EPA/AA) was ＞0.75. Furthermore, the ratio of prostaglandin (

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Early modifications of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids

Abstract: One gram per day of n-3 PUFA induces fast (within 1 week) and striking changes in blood composition of PUFA that may well explain their beneficial effects against cardiovascular diseases.

Cited by 68 publications

References 40 publications

Heart rate variability indices in the time domain in healthy dogs supplemented with omega n-3

Heart rate variability indices in the time domain in healthy dogs supplemented with omega n-3

Effect of the administration of n-3 polyunsaturated fatty acids on circulating levels of microparticles in patients with a previous myocardial infarction

Eicosapentaenoic Acid (EPA) Reduces Cardiovascular Events: Relationship with the EPA/Arachidonic Acid Ratio

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