2015
DOI: 10.1371/journal.pone.0132394
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Early Mortality during Initial Treatment of Tuberculosis in Patients Co-Infected with HIV at the Yaoundé Central Hospital, Cameroon: An 8-Year Retrospective Cohort Study (2006-2013)

Abstract: BackgroundUnderstanding contributors to mortality during the initial phase of tuberculosis (TB) treatment in patients co-infected with HIV would guide targeted interventions to improve survival. The aim of this study was to ascertain the incidence of death during the initial 2 months (new cases) and 3 months (retreatment cases) of TB treatment and to assess correlates of mortality in HIV co-infected patients.MethodsWe conducted a hospital-based retrospective cohort study from January 2006 to December 2013 at Y… Show more

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Cited by 21 publications
(28 citation statements)
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“…Future research should focus on developing simple risk assessment tools based on evidence from prospective cohort studies [ 30 , 41 ] to identify patient and treatment supporter factors which may potentially influence mortality during TB treatment. In addition, operational research is needed to monitor the quality of treatment supervision and performance of DOT.…”
Section: Discussionmentioning
confidence: 99%
“…Future research should focus on developing simple risk assessment tools based on evidence from prospective cohort studies [ 30 , 41 ] to identify patient and treatment supporter factors which may potentially influence mortality during TB treatment. In addition, operational research is needed to monitor the quality of treatment supervision and performance of DOT.…”
Section: Discussionmentioning
confidence: 99%
“…Tuberculosis (TB) is the leading cause of hospitalization and in‐hospital death in human immunodeficiency virus (HIV)‐infected people worldwide . In high‐burden settings hospitalized patients with HIV‐associated TB (HIV‐TB) have case fatality rates between 11 and 32% . The majority of these deaths occur within 2 weeks and in postmortem series inpatient HIV‐TB deaths are reported at a median of 4–5 days after admission, with 50% of deaths occurring in patients already on anti‐TB therapy …”
Section: Introductionmentioning
confidence: 99%
“…Most previous studies addressing TB related HIV deaths have focused only on assessing the relative contribution of TB to HIV related mortality. (7, 8) Also, most studies assessing TB burden among those with PLHIV used secondary data generated during routine service delivery, making disease burden quantification less reliable. (710).…”
Section: Introductionmentioning
confidence: 99%