Early Nephrectomy in Unilateral Multicystic Dysplastic Kidney in Children Cures Hypertension Early: An Observation

Abstract

Surgery is still indicated as the treatment of choice in subset of patients with unilateral multicystic dysplastic kidney (UMCDK) because of its potential complications and malignant change. The purpose of this study is to present our observation that early nephrectomy may cure hypertension early in children with UMCDK and review the literature. We report here four children (two males and two females) with antenatally diagnosed UMCDK with hypertension, treated in the past 4 years. All have antenatal diagnosis of UMCDK and referred to us after their birth. Diagnosis of hypertension (blood pressure> 95th percentile) was made after 3 months of follow-up in all patients. Nephrectomy was performed in all children in variable time duration. Hypertension, urinary tract infection, and desire of parents were the main indication of surgery. All children showed decrease in the size of their dysplastic kidney with time, but hypertension was persistent and needed antihypertensive drugs; even increase in the doses in successive follow-up. After nephrectomy, three children who were operated early got cured having normal blood pressure within variable time duration, while a child, operated late, still had high blood pressure and needed antihypertensive drugs. Early nephrectomy in recently diagnosed hypertension in UMCDK is advisable and can cure hypertension early. The level of evidence is IV (case series with no comparison group).

Agenezi veya Multikistik Displazi: Doğuştan Tek Böbrekli Çocuklarda Hangisi Daha Kötü?

“…23 Hipertansiyon açısından yüksek risk taşıyan ve medikal tedaviye dirençli olan hastalarda erken nefrektomi yapılması gerekliliğini savunan yayınlar da mevcuttur. 24 Çalışmamızda MKDB tanılı 2 hastanın 1 tanesine Wilms tümörü şüphesiyle, 1 tanesine ise aynı tarafta eşlik eden ileri derecede VUR nedeniyle nefrektomi uygulanmıştır. Buna göre nefrektomi yapılma oranı %2,6 idi.…”