Early Odontoblastic Layer Response to Cavity Preparation and Acid Etching in Rats

Németh, L; Erman, Andreja; Štiblar-Martinčič, Draga

doi:10.3409/173491606777919111

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…The odontoblastic layer appears with its shape close to normal with pesoudostratified appearance and multiple mitotic figures as a sign of regeneration interspersed by multiple proliferating blood vessels in between newly formed odontoblasts in different zones with predentin formation, The newly formed dentin (active dentinogenesis), characterized by very thick layer of predentin which demarcated from primary dentin by separating line. These results were close to the observation of other studies [14,[23][24][25] , they stated that, the increase in predentin width could indicate a faster recovery of primary odontoblasts, with the beginning of tertiary dentine synthesis after the injury, caused by cavity preparation.…”

Section: Discussionsupporting

confidence: 91%

Comparative Histological Study of Reparative Dentin Formation of Calcium Hydroxide and Zeolite in Pulpotomized Teeth (Histological Study)

Gobran

Ismael²,

Farouk³

et al. 2022

Al-Azhar Assiut Dental Journal

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Aim: Zeolites induce the proliferation and differentiation of cells of the osteoblast lineage. Application of zeolite in pulpotomized young permenat teeth had not been investigated. The objective of this study was to investigate histologicaly the capability of zeolite to induce dentin bridge formation and compare it with calcium hydroxide. Subjects and methods: Four dogs aged 12-24 month were included in the present study. In each dog, pulpotomy procedures were carried out in four premolars teeth in each quadrant and restored with one of the experimental materials in a way that teeth in each quadrant restored with one material differ from that of the contralateral quadrant.Specimens were harvested on the sixth week after operation and twelfth week after operative procedures, prepared and examined histologically by H&E (haematoxylin and eosin) stain, there were wide histological differences between the groups of this study along the different intervals of the study. Results: The result of the present study revealed inflammatory response of pulp tissue to both tested materials with various degrees that were subsided by time only in calcium hydroxide group. Calcium hydroxide has a powerful agent for regenerative effect on pulp tissue with dentin bridge formation.On the contrary; pulp degeneration and necrosis were the end results of pulpotomy with zeolite material. Conclusion: Calcium hydroxide could induce dentin bridge formation while zeolite failed.

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Section: Discussionsupporting

confidence: 91%

Comparative Histological Study of Reparative Dentin Formation of Calcium Hydroxide and Zeolite in Pulpotomized Teeth (Histological Study)

Gobran

Ismael²,

Farouk³

et al. 2022

Al-Azhar Assiut Dental Journal

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“…11 Several procedures can induce this alteration, characterized as a defense mechanism of the dentin-pulp complex against an applied external force. 41 Disruption of the odontoblastic layer, [13][14][15][16]20 cell-free zone, and predentin layer 14,15 were also observed. These changes were commonly observed in studies that assessed dental material biocompatibility, in which the rupture of these tissue zones' integrity characterized an adverse event to their use.…”

Section: Discussionmentioning

confidence: 97%

Effect of orthodontic force on dental pulp histomorphology and tissue factor expression:

Vitali¹,

Cardoso²,

Mello³

et al. 2021

The Angle Orthodontist

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Objectives To evaluate the effects of orthodontic force on histomorphology and tissue factor expression in the dental pulp. Materials and Methods Two reviewers comprehensively and systematically searched the literature in the following databases: Latin American and Caribbean Health Sciences, Embase, Cochrane, PubMed, Scopus, Web of Science, and Grey literature (Google Scholar, OpenGrey, and ProQuest) up to September 2020. According to the Population, Intervention, Comparison, Outcomes, Studies criteria, randomized clinical trials (RCTs) and observational studies that evaluated the effects of orthodontic force on dental pulp were included. Case series/reports, laboratory-based or animal studies, reviews, and studies that did not investigate the association between orthodontic force and pulpal changes were excluded. Newcastle-Ottawa Scale and Cochrane risk-of-bias tool were used to assess the risk of bias. The overall certainty level was evaluated with the Grading of Recommendations Assessment, Development and Evaluation tool. Results 26 observational studies and five RCTs were included. A detailed qualitative analysis of articles showed a wide range of samples and applied methodologies concerning impact of orthodontic force on the dental pulp. The application of orthodontic force seems to promote several pulpal histomorphological changes, including tissue architecture, cell pattern, angiogenesis, hard tissue deposition, inflammation, and alteration of the expression levels of 14 tissue factors. Conclusions Although the included articles suggest that orthodontic forces may promote histomorphological changes in the dental pulp, due to the very low-level of evidence obtained, there could be no well-supported conclusion that these effects are actually due to orthodontic movement. Further studies with larger samples and improved methods are needed to support more robust conclusions.

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“…With low ICDAS scores (ICDAS scores 1-3), the ADC maps of dental pulps are mainly homogenous with ADC well above the dental pulp decay threshold of 1.0 Á10 -9 m 2 /s. This is most likely due to successful regeneration and reparation processes in the dental hard and soft tissues, which slow the progression of caries (28). However, after enamel breakdown (ICDAS scores [4][5][6], an increase in ADC heterogeneity is apparent due to a more intense demineralization process in the hard dental tissues resulting in increased porosity and with it an associated excessive accumulation of edematous water in the dental pulp tissue.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the dentin‐pulp complex response to caries by ADC mapping

et al. 2012

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The prognostic potential of apparent diffusion coefficient (ADC) mapping was studied as complemented by high-resolution 3D T(1)-weighted MRI in the assessment of dentin-pulp complex response to caries. Twenty-six extracted human teeth, with or without caries lesions of different grades in accord with the International Caries Detection and Assessment System (ICDAS), were analyzed by high-resolution MRI at 2.35 T. A signal rise in demineralized hard dental tissues in high-resolution T(1)-weighted MR images enabled assessment of the demineralization depth over the whole range of ICDAS scores. ADC maps of the teeth were calculated from corresponding diffusion-weighted images of four different b values: 0, 132, 317, 635 s/mm(2). These maps enabled reliable differentiation between intact (ADC > 1.0·10(-9) m(2)/s) and affected (ADC < 1.0·10(-9) m(2)/s) regions of dental pulp. Linear regression analyses of demineralization depth in relation to ICDAS score and then also to average ADC of dental pulp showed that a demineralization depth increase of one millimeter corresponds to an ICDAS score increase of 1.2 and an average ADC decrease of 0.07·10(-9) m(2)/s. Results of the study indicate that the average ADC value of dental pulp could be used as a potential marker to assess tissue response to caries comparable to that of ICDAS scoring.

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Early Odontoblastic Layer Response to Cavity Preparation and Acid Etching in Rats

Cited by 6 publications

References 26 publications

Comparative Histological Study of Reparative Dentin Formation of Calcium Hydroxide and Zeolite in Pulpotomized Teeth (Histological Study)

Comparative Histological Study of Reparative Dentin Formation of Calcium Hydroxide and Zeolite in Pulpotomized Teeth (Histological Study)

Effect of orthodontic force on dental pulp histomorphology and tissue factor expression:

Assessment of the dentin‐pulp complex response to caries by ADC mapping

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