Early-Onset Colorectal Cancer Is Associated with a Lower Risk of Metachronous Advanced Neoplasia than Traditional-Onset Colorectal Cancer

Chen, Frank W.; Yang, Liu; Cusumano, Vivy T.; Chong, Michelle; Lin, Jonathan K.; Partida, Diana; May, Folasade P.

doi:10.1007/s10620-021-06902-w

Cited by 7 publications

(13 citation statements)

References 20 publications

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“…In a retrospective case-control study (107 eoCRC and 139 loCRC), patients received similar recommendations for endoscopic surveillance after curative surgery, but patients with eoCRC were more adherent to recommendations (71% versus 55%; P ¼ .01). 102 The risk of metachronous advanced adenoma or CRC after curative resection was lower for patients with eoCRC (adjusted HR, 0.44; 95% CI, 0.22-0.88). 102 The 5-year event rate for metachronous advanced adenoma and CRC was lower for patients with eoCRC (5.8% vs 16.1%; P ¼ .07).…”

Section: Le: 3bmentioning

confidence: 92%

“…102 The risk of metachronous advanced adenoma or CRC after curative resection was lower for patients with eoCRC (adjusted HR, 0.44; 95% CI, 0.22-0.88). 102 The 5-year event rate for metachronous advanced adenoma and CRC was lower for patients with eoCRC (5.8% vs 16.1%; P ¼ .07). 102…”

Section: Le: 3bmentioning

confidence: 92%

“…The systematic review found 6 studies evaluating the risk of eoCRC among different ethnicities, with 2 studies having LE 1b. They all concluded that black individuals have a higher risk of eoCRC, but the incidence and prevalence of eoCRC have remained the A full summary of relevant evidence for R.1 21,30,31,39,42,47,51,53,54,56,59,74,76,78,[90][91][92][93][94][95][96][97][98][99][100][101][102] and R. 29,30,31,36,[65][66][67][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85]…”

Section: Genetics Of Early-onset Colorectal Cancer (G)mentioning

confidence: 99%

“…More extensive surgical resection cannot be recommended for eoCRC patients who do not have a distinct risk-enhancing predisposition (particularly a hereditary CRC syndrome or ulcerative colitis). 102,209,213 Although subtotal or total colectomy offers a benefit in reducing risk for metachronous CRC in patients with LS and familial adenomatous polyposis, more extensive surgery did not offer a survival benefit in LS. 107,108,[214][215][216] For patients with LS, the cumulative incidence of gynecologic cancers (endometrial or ovarian) before 50 years of age is high (the risk of endometrial cancer by age 50 in female carriers of MSH2 and MSH6 PV/LPVs exceeds that of CRC, and it is roughly the same among MLH1 female carriers).…”

Section: Session Vi: Treatment (T)mentioning

confidence: 99%

“…In a retrospective case-control study (107 eoCRC and 139 loCRC), patients with eoCRC more commonly had a family history of CRC (30% vs 16%, P ¼ .02). 102…”

Section: Le: 3bmentioning

confidence: 99%

See 4 more Smart Citations

Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines

Giulia

Mannucci

Balaguer

et al. 2023

Clinical Gastroenterology and Hepatology

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Section: Le: 3bmentioning

confidence: 92%

Section: Le: 3bmentioning

confidence: 92%

Section: Genetics Of Early-onset Colorectal Cancer (G)mentioning

confidence: 99%

Section: Session Vi: Treatment (T)mentioning

confidence: 99%

“…In a retrospective case-control study (107 eoCRC and 139 loCRC), patients with eoCRC more commonly had a family history of CRC (30% vs 16%, P ¼ .02). 102…”

Section: Le: 3bmentioning

confidence: 99%

See 3 more Smart Citations

Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines

Giulia

Mannucci

Balaguer

et al. 2023

Clinical Gastroenterology and Hepatology

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The diagnostic yield of colonoscopic surveillance following resection of early age onset colorectal cancer

Al Maliki,

Monahan

2024

UEG Journal

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BackgroundThe primary benefit of post‐colorectal cancer (CRC) colonoscopic surveillance is to detect and remove premalignant lesions to prevent metachronous CRC. Current guidelines for long‐term colonoscopic surveillance post early age onset CRC (EOCRC) resection are based on limited evidence. The aims of this study were to assess the diagnostic yield of colonoscopic surveillance post‐EOCRC resection and identify molecular and clinicopathological risk factors associated with advanced neoplasia.MethodologyA retrospective cohort study of prospectively collected data was conducted at St Mark's hospital, London, United Kingdom, for patients diagnosed with EOCRC who underwent at least one episode of post‐CRC colonoscopic surveillance between 1978 and 2022. We collected clinicopathological data including tumour molecular status and neoplasia detection rates.ResultsIn total, 908 colonoscopic surveillance procedures were performed in 195 patients over 2581.3 person‐years of follow‐up. The diagnostic yields of metachronous CRC, advanced adenomas and non‐advanced adenomas were 1.76%, 3.41% and 22.69% respectively. Sixteen patients (8.21%) developed metachronous CRC, and the majority (87.5%) were detected more than 3 years post index EOCRC diagnosis. Detection of advanced neoplasia was significantly higher in EOCRC patients with Lynch syndrome (26.15%) compared with those in whom Lynch syndrome was excluded (13.13%) (OR, 2.343; 95% CI, 1.014–5.256; p = 0.0349).ConclusionsDuring colonoscopic surveillance post‐EOCRC resection, the long‐term risk of developing metachronous advanced neoplasia remains high in the context of Lynch syndrome, but this trend is not as clearly evident when Lynch syndrome has been excluded.

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Incidence and risk outcomes of second primary malignancy of patients with post-operative colorectal cancer

Yang

et al. 2023

Int J Colorectal Dis

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Early-Onset Colorectal Cancer Is Associated with a Lower Risk of Metachronous Advanced Neoplasia than Traditional-Onset Colorectal Cancer

Cited by 7 publications

References 20 publications

Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines

Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines

The diagnostic yield of colonoscopic surveillance following resection of early age onset colorectal cancer

Incidence and risk outcomes of second primary malignancy of patients with post-operative colorectal cancer

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