Early plasma interferon‐β levels as a predictive marker of COVID‐19 severe clinical events in adult patients

Berri, Fatma; N’Guyen, Yohan; Callon, Domitille; Lebreil, Anne-Laure; Glenet, M.; Heng, Laetitia; Bach-Nga, Pham; Bani‐Sadr, Firouzé

doi:10.1002/jmv.28361

Cited by 11 publications

(1 citation statement)

References 15 publications

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“…Furthermore, IFN-β assumes a pivotal role in robust antiviral defence and serves as a significant link between innate and adaptive immune responses [ 58 , 59 ]. However, elevated levels of IFN-β can exert detrimental effects during viral infections.…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange

Alfaro,

Díaz-García,

García-Tovar

et al. 2024

BMC Med

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Background Understanding the enduring respiratory consequences of severe COVID-19 is crucial for comprehensive patient care. This study aims to evaluate the impact of post-COVID conditions on respiratory sequelae of severe acute respiratory distress syndrome (ARDS). Methods We examined 88 survivors of COVID-19-associated severe ARDS six months post-intensive care unit (ICU) discharge. Assessments included clinical and functional evaluation as well as plasma biomarkers of endothelial dysfunction, inflammation, and viral response. Additionally, an in vitro model using human umbilical vein endothelial cells (HUVECs) explored the direct impact of post-COVID plasma on endothelial function. Results Post-COVID patients with impaired gas exchange demonstrated persistent endothelial inflammation marked by elevated ICAM-1, IL-8, CCL-2, and ET-1 plasma levels. Concurrently, systemic inflammation, evidenced by NLRP3 overexpression and elevated levels of IL-6, sCD40-L, and C-reactive protein, was associated with endothelial dysfunction biomarkers and increased in post-COVID patients with impaired gas exchange. T-cell activation, reflected in CD69 expression, and persistently elevated levels of interferon-β (IFN-β) further contributed to sustained inflammation. The in vitro model confirmed that patient plasma, with altered levels of sCD40-L and IFN-β proteins, has the capacity to alter endothelial function. Conclusions Six months post-ICU discharge, survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange. NLRP3 inflammasome activity and persistent T-cell activation indicate on going inflammation contributing to persistent endothelial dysfunction, potentially intensified by sustained viral immune response.

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Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange

Alfaro,

Díaz-García,

García-Tovar

et al. 2024

BMC Med

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Early plasma interferon‐β levels as a predictive marker of COVID‐19 severe clinical events in adult patients

Berri

N’Guyen

Callon

et al. 2022

Journal of Medical Virology

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We assessed relationships between early peripheral blood type I interferons (IFN) levels, clinical new early warning scores (NEWS), and clinical outcomes in hospitalized coronavirus disease‐19 (COVID‐19) adult patients. Early IFN‐β levels were lower among patients who further required intensive care unit (ICU) admission than those measured in patients who did not require an ICU admission during severe acute respiratory syndrome coronavirus type 2 infection. IFN‐β levels were inversely correlated with NEWS only in the subgroup of patients who further required ICU admission. To assess whether peripheral blood IFN‐β levels could be a potential relevant biomarker to predict further need for ICU admission, we performed receiver operating characteristic (ROC) curve analyses that showed for all study patients an area under ROC curve of 0.77 growing to 0.86 (p = 0.003) when the analysis was restricted to a subset of patients with NEWS ≥5 at the time of hospital admission. Overall, our findings indicated that early peripheral blood IFN‐β levels might be a relevant predictive marker of further need for an ICU admission in hospitalized COVID‐19 adult patients, specifically when clinical score (NEWS) was graded as upper than 5 at the time of hospital admission.

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SARS-CoV-2 rapidly evolves lineage-specific phenotypic differences when passaged repeatedly in immune-naïve mice

Willett,

Gravel,

Dubuc

et al. 2024

Commun Biol

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The persistence of SARS-CoV-2 despite the development of vaccines and a degree of herd immunity is partly due to viral evolution reducing vaccine and treatment efficacy. Serial infections of wild-type (WT) SARS-CoV-2 in Balb/c mice yield mouse-adapted strains with greater infectivity and mortality. We investigate if passaging unmodified B.1.351 (Beta) and B.1.617.2 (Delta) 20 times in K18-ACE2 mice, expressing the human ACE2 receptor, in a BSL-3 laboratory without selective pressures, drives human health-relevant evolution and if evolution is lineage-dependent. Late-passage virus causes more severe disease, at organism and lung tissue scales, with late-passage Delta demonstrating antibody resistance and interferon suppression. This resistance co-occurs with a de novo spike S371F mutation, linked with both traits. S371F, an Omicron-characteristic mutation, is co-inherited at times with spike E1182G per Nanopore sequencing, existing in different within-sample viral variants at others. Both S371F and E1182G are linked to mammalian GOLGA7 and ZDHHC5 interactions, which mediate viral-cell entry and antiviral response. This study demonstrates SARS-CoV-2’s tendency to evolve with phenotypic consequences, its evolution varying by lineage, and suggests non-dominant quasi-species contribution.

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Early plasma interferon‐β levels as a predictive marker of COVID‐19 severe clinical events in adult patients

Cited by 11 publications

References 15 publications

Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange

Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange

Early plasma interferon‐β levels as a predictive marker of COVID‐19 severe clinical events in adult patients

SARS-CoV-2 rapidly evolves lineage-specific phenotypic differences when passaged repeatedly in immune-naïve mice

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