Early postnatal experience and DRD2 genotype affect dopamine receptor expression in the rat ventral striatum

Lovic, Vedran; Belay, Hiwote T.; Walker, Claire‐Dominique; Burton, Christie L.; Meaney, Michael J.; Sokolowski, Marla B.; Fleming, Alison S.

doi:10.1016/j.bbr.2012.09.046

Cited by 31 publications

(24 citation statements)

References 22 publications

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“…Our results demonstrating the downregulation of D2‐like receptors in the striatum of MS females indicate that ELS may predispose adolescent females to the abovementioned problems. Moreover, our results are consistent with previous data, which have shown that the Drd2 genotype interacts with early‐life adversity to affect D2 receptor expression in the Acb (Lovic et al, 2013). On the other hand, imbalance between D1‐like and D2‐like receptors within the medial PFC may relate to deficits in working memory, emotional memory and attention (Avery and Krichmar, 2015; Lauzon et al, 2013).…”

Section: Discussionsupporting

confidence: 93%

The effects of early‐life stress on dopamine system function in adolescent female rats

Majcher-Maślanka

Solarz

Wędzony

et al. 2017

Intl J of Devlp Neuroscience

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During adolescence, many neural systems, including the dopamine system, undergo essential remodeling and maturation. It is well known that early-life stress (ELS) increases the risk for many psychopathologies during adolescence and adulthood. It is hypothesized that ELS interferes with the maturation of the dopamine system. There is a sex bias in the prevalence of stress-related mental disorders. Information regarding the effects of ELS on brain functioning in females is very limited. In the current study, maternal separation (MS) procedures were carried out to study the effects of ELS on dopamine system functioning in adolescent female rats. Our study showed that MS increased the density of tyrosine hydroxylase immunoreactive fibers in the prelimbic cortex (PLC) and nucleus accumbens (Acb). These changes were accompanied by a decrease in the level of D5 receptor mRNA and an increase in D2 receptor mRNA expression in the PLC of MS females. Conversely, D1 and D5 receptor mRNA levels were augmented in the caudate putamen (CPu), while the expression of the D3 dopamine receptor transcript was reduced in MS females. Additionally, in the Acb, MS elicited a decrease in D2 receptor mRNA expression. At the behavioral level, MS increased apomorphine-induced locomotion; however, it did not change locomotor responses to selective D1/D5 receptor agonist and attenuated D2/D3 receptor agonist-triggered locomotion. Moreover, MS decreased D1/D5 receptor agonist-induced grooming behavior. These results indicate that ELS disrupts dopamine receptor function in the PLC and basal ganglia during adolescence in females and may predispose them to psychopathologies during adolescence and adulthood.

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Section: Discussionsupporting

confidence: 93%

The effects of early‐life stress on dopamine system function in adolescent female rats

Majcher-Maślanka

Solarz

Wędzony

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

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“…The data are consistent with effects of developmental stress reported by others inasmuch as prenatal restraint stress has been shown to alter midbrain dopamine (Baier et al, 2012). There is also evidence that prenatal stress alters dopamine receptors, dendritic morphology, and basal and stimulated dopamine release by in vivo microdialysis in the striatum (Silvagni et al, 2008; Martinez-Tellez et al, 2009; Lovic et al, 2013). While not the same as the stressor we used, such data suggest a link between developmental stress and dopaminergic function that could affect egocentric learning.…”

Section: Discussionmentioning

confidence: 99%

Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory

Amos‐Kroohs

Davenport

Atanasova

et al. 2017

Neurotoxicology and Teratology

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Manganese (Mn) is an essential element but neurotoxic at higher exposure levels. The effects of Mn overexposure (MnOE) on hippocampal and striatal-dependent learning and memory in rats were tested in combination with iron deficiency (FeD) and developmental stress that often co-occur with MnOE. Moderate FeD affects up to 15% of U.S. children and developmental stress is common in lower socio-economic areas where MnOE occurs. Pregnant Sprague-Dawley rats and their litters were housed in cages with or without (barren cage (BAR)) standard bedding from embryonic day (E)7 to postnatal day (P)28. Dams were fed a 90% FeD or iron sufficient (FeS) diet from E15-P28. Within each litter, separate offspring were treated with 100 mg/kg Mn (MnOE) or vehicle (VEH) by gavage on alternate days from P4-28. Offspring were tested as adults in the Morris and Cincinnati water mazes. FeD and developmental stress interactively impaired spatial learning in the Morris water maze. Developmental stress and MnOE impaired learning and memory in both mazes. MnOE resulted in reduced CA1 hippocampal long-term potentiation (LTP) and increased levels of α-synuclein. Preweaning MnOE results in cognitive deficits on multiple domains of learning and memory accompanied by impaired LTP and α-synuclein changes, effects worsened by developmental stress.

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“…During critical developmental periods when plasticity is heightened, the brain may be particularly sensitive to the destructive effects of adverse experiences on neural function (Rodrigues et al 2011). In rodents, early life stress is associated with increased tissue levels and reduced rate of DA clearance in the striatum (Matthews et al 2001; Womersley et al 2011), as well as altered levels of D2 receptor expression, which vary as a function of D2 polymorphisms (Lovic et al 2013). Several investigators have reported enhanced striatal DA responses to later stress in rodents exposed to early life adversity (Brake et al 2004; Fulford and Marsden.…”

Section: Discussionmentioning

confidence: 99%

History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

et al. 2014

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Childhood exposure to severe or chronic trauma is an important risk factor for the later development of adult mental health problems, such as substance abuse. Even in nonclinical samples of healthy adults, persons with a history of significant childhood adversity seem to experience greater psychological distress than those without this history. Evidence from rodent studies suggests that early life stress may impair dopamine function in ways that increase risks for drug abuse. However, the degree to which these findings translate to other species remains unclear. This study was conducted to examine associations between childhood adversity and dopamine and subjective responses to amphetamine in humans. Following intake assessment, 28 healthy male and female adults, ages 18–29 years, underwent two consecutive 90-minute positron emission tomography (PET) studies with high specific activity [11C]raclopride. The first scan was preceded by intravenous saline; the second by amphetamine (AMPH 0.3 mg/kg). Consistent with prior literature, findings showed positive associations between childhood trauma and current levels of perceived stress. Moreover, greater number of traumatic events and higher levels of perceived stress were each associated with higher ventral striatal dopamine responses to AMPH. Findings of mediation analyses further showed that a portion of the relationship between childhood trauma and dopamine release may be mediated by perceived stress. Overall, results are consistent with preclinical findings suggesting that early trauma may lead to enhanced sensitivity to psychostimulants and that this mechanism may underlie increased vulnerability for drug abuse.

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Early postnatal experience and DRD2 genotype affect dopamine receptor expression in the rat ventral striatum

Cited by 31 publications

References 22 publications

The effects of early‐life stress on dopamine system function in adolescent female rats

The effects of early‐life stress on dopamine system function in adolescent female rats

Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory

History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

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