Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development

Yoshizaki, Kaichi; Koike, Kazuhide; Kimura, Reiji; Osumi, Noriko

doi:10.1371/journal.pone.0186798

Cited by 10 publications

(11 citation statements)

References 36 publications

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“…Our results contribute to previous reports integrating isolation calls into the study of the development of individual differences in behavioural traits (Hudson et al, ; Yoshizaki, Koike, Kimura, & Osumi, ). For example, pups’ isolation calls have been shown to be linked with sociability, spatial memory and emotionality in adults (laboratory rats: Brunelli & Hofer, ; laboratory mice: Winslow et al, ; Yoshizaki et al, ).…”

Section: Discussionsupporting

confidence: 88%

Isolation calls in house mouse pups: Individual consistency across time and situations

Verjat

Rödel

Féron

2019

Developmental Psychobiology

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Isolation calls are emitted by the offspring of many mammalian species when separated from caregivers and siblings. Some studies indicate that isolation call rates constitute a consistent individual trait; others show that the young adjust their vocalization rate to the current situation. We studied this in the house mouse (Mus musculus domesticus) by exploring individual consistencies in pup isolation call rates and their potential modulation in different social situations. We carried out experiments including three treatments (repeated measurements) during consecutive days, all starting with an initial isolation of the pup, followed by (a) a reunion with mother and littermates and a second isolation hereafter, (b) the confrontation of isolated pup with cues of its own nest or (c) with cues of an unfamiliar adult male. The first treatment induced a significant increase, while the others induced significant decreases in pup isolation call rates. Pups showed consistent individual differences in initial call rates across the three days of testing (postnatal days 9–11), which were significantly associated with individual differences in call rates during the different treatments. We conclude that pup isolation calls represent a consistent, trait‐like behaviour in the house mouse, which can also express flexibility in response to social cues.

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Section: Discussionsupporting

confidence: 88%

Isolation calls in house mouse pups: Individual consistency across time and situations

Verjat

Rödel

Féron

2019

Developmental Psychobiology

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“…Since one objective of our research was to examine whether HFD-induced obesity was a risk factor for psychiatric disorders and cognitive impairment, we analyzed the correlation between body weight and behavioral traits, according to a previous paper [35]. We unexpectedly found that HFD-induced body weight was not associated with either hyperlocomotion or anhedonia-like behavior.…”

Section: Discussionmentioning

confidence: 99%

High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test

2020

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Obesity is characterized by massive adipose tissue accumulation and is associated with psychiatric disorders and cognitive impairment in human and animal models. However, it is unclear whether high-fat diet (HFD)-induced obesity presents a risk of psychiatric disorders and cognitive impairment. To examine this question, we conducted systematic behavioral analyses in C57BL/6J mice (male, 8-week-old) fed an HFD for 7 weeks. C57BL/6J mice fed an HFD showed significantly increased body weight, hyperlocomotion in the open-field test (OFT) and Y-maze test (YMZT), and impaired sucrose preference in the sucrose consumption test, compared to mice fed a normal diet. Neither body weight nor body weight gain was associated with any of the behavioral traits we examined. Working memory, as assessed by the YMZT, and anxiety-like behavior, as assessed by the elevated plus maze test (EPMT), were significantly correlated with mice fed an HFD, although these behavioral traits did not affect the entire group. These results suggest that HFD-induced obesity does not induce neuropsychiatric symptoms in C57BL/6J mice. Rather, HFD improved working memory in C57BL/6J mice with less anxiety, indicating that an HFD might be beneficial under limited conditions. Correlation analysis of individual traits is a useful tool to determine those conditions.

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“…Significant individual differences in USVs have been observed in mice and rats, as well as in the individual variation in immune responses . Particularly interesting in the context of this article is the work of Bronson and colleagues, who using a poly I:C MIA model in rats reported that individual differences in the maternal response to immune challenge influence the behavioral response in the offspring …”

Section: Common Traits Between Immunity and Vocalizationmentioning

confidence: 91%

Immunity and ultrasonic vocalization in rodents

Jouda

Wöhr

Rey

2018

Annals of the New York Academy of Sciences

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Ultrasonic vocalizations (USVs) serve important communicative functions in rodents. Different types of USVs can be triggered in the sender, for example, by maternal separation, social interactions, or exposure to predators, and they evoke affiliative or alarming behaviors in recipients. This review focusses on studies evaluating possible links between immunity and USVs. Most studies have been performed in a murine model of maternal immune activation and subsequent evaluation of effects in the offspring. This model has received large attention in recent years because it mimics behavioral abnormalities observed in certain human neuropsychiatric disorders, including autism spectrum disorder. Although there is still some controversy, the results indicate that stimulation of the immune system of mice and rats during pregnancy affects ultrasonic calling in pups. Few studies are available on immunization during adulthood and USVs. In most cases, immune stimulation led to disease, complicating conclusions about a possible direct link between vocalization and immunity. Although much work is still needed, this is certainly a rather new and promising aspect of interactions between the immune system and behavior.

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Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development

Cited by 10 publications

References 36 publications

Isolation calls in house mouse pups: Individual consistency across time and situations

Isolation calls in house mouse pups: Individual consistency across time and situations

High-Fat Diet Enhances Working Memory in the Y-Maze Test in Male C57BL/6J Mice with Less Anxiety in the Elevated Plus Maze Test

Immunity and ultrasonic vocalization in rodents

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