Early prediction of refractory epilepsy in childhood

Ramos-Lizana, Julio; Aguilera-López, P.; Aguirre-Rodríguez, J.; Cassinello-García, E.

doi:10.1016/j.seizure.2009.02.006

Cited by 26 publications

(14 citation statements)

References 24 publications

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“…Its occurrence in early childhood was strongly correlated with later drug resistance (Cramer's V = 0.6). Studies by other authors such as Sillanpaa [6], Ramos-Lizana et al [8], Mohanraj and Brodie [10], and Gurruraj et al [13] also revealed the relation between status epilepticus and drug-resistant epilepsy.…”

Section: Discussionmentioning

confidence: 83%

“…In our study this was also one of the most influential risk factors for drug-resistant epilepsy (Cramer's V = 0.62). This view is shared by most authors [6,8,13,22,25]. According to Camifield, normal intellectual development is fundamental for good prognosis in epilepsy [26].…”

Section: Discussionmentioning

confidence: 96%

“…In our study this was the most influential risk factor for drug-resistant epilepsy (Cramer's V = 0.66). According to most authors, it conditions the occurrence of drug resistance to the highest degree [6,[8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…The most frequently mentioned clinical factors include the following: initial antiepileptic treatment [6,7], considerable initial frequency of epileptic seizures [6,[8][9][10][11][12], occurrence of status epilepticus [6,[13][14][15][16][17], symptomatic aetiology of epilepsy [6,16,18], type of epilepsy/epileptic syndrome [11,13,14,16,[19][20][21][22], onset of epileptic seizures before the first birthday [13,15,18,23,24], abnormal results of neurological examination [8,18,23,24,25], and abnormalities detected in imaging [18,23] and EEG examinations [15,16,18].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of clinical risk factors for drug-resistant epilepsy in children and teenagers

Kasprzyk¹,

Brola²,

Wendorff³

2014

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Introduction: Epilepsy is one of the most common neurological illnesses occurring in children. In approximately 20-30% of cases it is drug-resistant. Aim of the research: To assess the already-known risk factors, analyse the rarely described ones, and find new causes of epilepsy drug resistance in children, taking into account the level of impact of each factor. Material and methods:The study comprised 152 of all 383 children hospitalised in 2012 at the Neurology Department of the Polish Mother's Memorial Hospital in Lodz due to epilepsy. Based on medical documentation, neurological examination, and our own questionnaire, we divided patients into two groups: drug-resistant epilepsy or drug-sensitive epilepsy. We compared the type, level of influence, and prevalence of different factors. For statistical analysis, the χ 2 test was used. Statistical significance was set at p < 0.05. Results: Drug-resistant epilepsy was found in 64 patients (42.1%), and drug-sensitive epilepsy was found in 88 patients (57.9%). Factors that were most probable to cause drug resistance included: high prevalence of seizures (Cramer's V = 0.66), type of epileptic syndrome (V = 0.62), psychomotor developmental delay (V = 0.62), and occurrence of status epilepticus (V = 0.6). Factors such as infections of CNS in early childhood, repeated severe infections of airways in childhood, and mother's infectious diseases with high fever during pregnancy were rare or non occurring (Cramer's V = 0.41, 0.32, and 0.31, respectively). Conclusions: The study confirmed the previously known causes of drug resistance and indicated the significance of underestimated inflammatory and infectious factors involving pyrexia, in children and also in mothers during pregnancy.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of clinical risk factors for drug-resistant epilepsy in children and teenagers

Kasprzyk¹,

Brola²,

Wendorff³

2014

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“…Sillanpaa found patients having refractory epilepsy had high initial seizure frequency 22 . In a recent study, a model comprising these variables (etiology, age at onset of epilepsy and number of seizures during first 6 months after diagnosis) had classified patients in groups with low, intermediate and high risk of refractory epilepsy 23 . This study showed that patients with a previous history of status epilepticus, prenatal insult, delayed mile stones and significant head trauma are at risk of uncontrolled seizure.…”

Section: Discussionmentioning

confidence: 99%

Common Factors Responsible for Uncontrolled Epilepsy Patients attended at a Tertiary Care Hospital in Bangladesh

Mian

Hussain

Islam

et al. 2018

J. Natl Inst. Neurosci Bangladesh

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Background: Epilepsy is a common neurological disorder. It is estimated that there are at least 1.5 to 2 million epilepsy patients in Bangladesh3. Many of these patients are suffering from uncontrolled epilepsy which leads to cognitive deterioration, psychosocial dysfunction and increased morbidity and mortality. The causes behind uncontrolled epilepsy are multifactorial. Some are patient-related, some physician-related and some are medication-related. Objective: The purpose of the present study was to identify the factors responsible for uncontrolled epilepsy. Methodology: This case-control study was carried out in the epilepsy clinic of the Dhaka Medical College Hospital, Dhaka, Bangladesh from July 2010 to June 2012 (2 years). A total of 100 patients of which 50 consecutive patients of uncontrolled epilepsy (cases) and 50 age-matched controls with well controlled epilepsy (control) were recruited. Patients were interviewed according to a preformed questionnaire. Results: The mean ages of case and control groups were 21.84 ± 8.70 and 23.94 ± 10.28 years (p=0.273). The male female ratio was almost equal in both groups. The factors which turned out significant (p value <0.05) for uncontrolled epilepsy were lack of support from the family (p=0.032), lack of motivation about the disease (p=0.001), unavailability of drugs (p=0.001), irregular intake of anti-epileptic drugs (p=0.001), stopping AEDs willingly after transient control of seizures (p=0.001), lack of knowledge about the disease (p=0.003), treatment duration (p=0.005) & prognosis of the disease (p=0.026). Other factors were low annual income of the family (p=0.001), occupation (p=0.040), lower educational status (p=0.027) and residence in rural area (p=0.016). Important patient related factors were earlier age of onset of seizure (p=0.027), higher initial seizure frequency (p=0.012), associated clinical features (neurological deficits, mental retardation, behavioral abnormality) (p=0.030), abnormal brain imaging findings (p=0.013) and non response to first anti epileptic drug (p=0.005). Conclusion: Many of the factors behind uncontrolled epilepsy can be minimized by proper counseling of the patient at the start of treatment and regular follow up.

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CYP2C9 (2&3) and CYP2C19 (2&3) polymorphisms among children with nonlesional epilepsy: a single-center study

et al. 2020

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Early prediction of refractory epilepsy in childhood

Abstract: Risk of developing refractory epilepsy is very low in idiopathic syndromes. For the rest of patients, a simple model comprising three variables allows more accurate prediction of risk of refractoriness.

Cited by 26 publications

References 24 publications

Assessment of clinical risk factors for drug-resistant epilepsy in children and teenagers

Assessment of clinical risk factors for drug-resistant epilepsy in children and teenagers

Common Factors Responsible for Uncontrolled Epilepsy Patients attended at a Tertiary Care Hospital in Bangladesh

CYP2C9 (2&3) and CYP2C19 (2&3) polymorphisms among children with nonlesional epilepsy: a single-center study

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Early prediction of refractory epilepsy in childhood

Abstract: Risk of developing refractory epilepsy is very low in idiopathic syndromes. For the rest of patients, a simple model comprising three variables allows more accurate prediction of risk of refractoriness.

Cited by 26 publications

References 24 publications

Assessment of clinical risk factors for drug-resistant epilepsy in children and teenagers

Assessment of clinical risk factors for drug-resistant epilepsy in children and teenagers

Common Factors Responsible for Uncontrolled Epilepsy Patients attended at a Tertiary Care Hospital in Bangladesh

CYP2C9 (*2&*3) and CYP2C19 (*2&*3) polymorphisms among children with nonlesional epilepsy: a single-center study

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CYP2C9 (2&3) and CYP2C19 (2&3) polymorphisms among children with nonlesional epilepsy: a single-center study