Early pregnancy maternal trace mineral status and the association with adverse pregnancy outcome in a cohort of Australian women

Wilson, Rebecca L.; Bianco‐Miotto, Tina; Leemaqz, Shalem; Grzeskowiak, Luke E.; Dekker, Gustaaf A.; Roberts, Claire T.

doi:10.1016/j.jtemb.2017.11.016

Cited by 71 publications

(79 citation statements)

References 44 publications

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“…A number of studies have reported average plasma selenium concentrations far below this value (Stoffaneller & Morse, ), including within cohorts of pregnant women (Wilson et al . ). At concentrations below this level, selenoproteins that are essential for pregnancy health, may function at suboptimal levels, leading to impaired fetal growth, which may, in turn, program disease in offspring.…”

Section: Introductionmentioning

confidence: 97%

“…Research has suggested that, to maximize activity of the essential selenoprotein anti-oxidant glutathione peroxidase (GPX), plasma selenium concentrations in humans should be ß100 µg L -1 (Stoffaneller & Morse, 2015). A number of studies have reported average plasma selenium concentrations far below this value (Stoffaneller & Morse, 2015), including within cohorts of pregnant women (Wilson et al 2018). At concentrations below this level, selenoproteins that are essential for pregnancy health, may function at suboptimal levels, leading to impaired fetal growth, which may, in turn, program disease in offspring.…”

Section: Introductionmentioning

confidence: 99%

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Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

Hofstee

Bartho

McKeating

et al. 2019

The Journal of Physiology

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Key points Inappropriate intake of key micronutrients in pregnancy is known to alter maternal endocrine status, impair placental development and induce fetal growth restriction. Selenium is an essential micronutrient required for the function of approximately 25 important proteins. However, the specific effects of selenium deficiency during pregnancy on maternal, placental and fetal outcomes are poorly understood. The present study demonstrates that maternal selenium deficiency increases maternal triiodothyronine and tetraiodothyronine concentrations, reduces fetal blood glucose concentrations, and induces fetal growth restriction. Placental expression of key selenium‐dependent thyroid hormone converting enzymes were reduced, whereas the expression of key placental nutrient transporters was dysregulated. Selenium deficiency had minimal impact on selenium‐dependent anti‐oxidants but increased placental copper concentrations and expression of superoxide dismutase 1. These results highlight the idea that selenium deficiency during pregnancy may contribute to thyroid dysfunction, causing reduced fetal growth, that may precede programmed disease outcomes in offspring. Abstract Selenium is a trace element fundamental to diverse homeostatic processes, including anti‐oxidant regulation and thyroid hormone metabolism. Selenium deficiency in pregnancy is common and increases the risk of pregnancy complications including fetal growth restriction. Although altered placental formation may contribute to these poor outcomes, the mechanism by which selenium deficiency contributes to complications in pregnancy is poorly understood. Female C57BL/6 mice were randomly allocated to control (>190 µg kg–1, n = 8) or low selenium (<50 µg kg–1, n = 8) diets 4 weeks prior to mating and throughout gestation. Pregnant mice were killed at embryonic day 18.5 followed by collection of maternal and fetal tissue. Maternal and fetal plasma thyroid hormone concentrations were analysed, as was placental expression of key selenoproteins involved in thyroid metabolism and anti‐oxidant defences. Selenium deficiency increased plasma tetraiodothyronine and triiodothyronine concentrations. This was associated with a reduction in placental expression of key selenodependent deiodinases, DIO2 and DIO3. Placental expression of selenium‐dependent anti‐oxidants was unaffected by selenium deficiency. Selenium deficiency reduced fetal glucose concentrations, leading to reduced fetal weight. Placental glycogen content was increased within the placenta, as was Slc2a3 mRNA expression. This is the first study to demonstrate that selenium deficiency may reduce fetal weight through increased maternal thyroid hormone concentrations, impaired placental thyroid hormone metabolism and dysregulated placental nutrient transporter expression. The study suggests that the magnitude of selenium deficiency commonly reported in pregnant women may be sufficient to impair thyroid metabolism but not placental anti‐oxidant concentrations.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

Hofstee

Bartho

McKeating

et al. 2019

The Journal of Physiology

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“…Epidemiological data indicate that adverse pregnancy outcomes and pregnancy complications, including preterm births, preeclampsia (PE), gestational diabetes, and fetal growth restriction (IUGR), occur in total in up to 25% of first pregnancies [1] and these pregnancy results are an important element of public health. They are associated with an increase in maternal and fetal morbidity and/or mortality [2][3][4][5][6][7][8][9][10] and they may lead to long-term diseases of both the mother and the child, increasing the risk of cardiovascular diseases, obesity, diabetes, and even some cancers, as well as neurodevelopmental disorders in the offspring [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

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Microelements involved in the oxidative balance have a significant impact on human health, but their role in pregnancy are poorly studied. We examined the relationships between first trimester levels of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu), as well as maternal characteristics and pregnancy results. The data came from a Polish prospective cohort of women in a single pregnancy without chronic diseases. A group of 563 women who had a complete set of data, including serum microelements in the 10–14th week was examined, and the following were found: 47 deliveries <37th week; 48 cases of birth weight <10th and 64 newborns >90th percentile; 13 intrauterine growth restriction (IUGR) cases; 105 gestational hypertension (GH) and 15 preeclampsia (PE) cases; and 110 gestational diabetes mellitus (GDM) cases. The microelements were quantified using mass spectrometry. The average concentrations (and ranges) of the elements were as follows: Se: 60.75 µg/L (40.91–125.54); Zn: 618.50 µg/L (394.04–3238.90); Cu: 1735.91 µg/L (883.61–3956.76); and Fe: 1018.33 µg/L (217.55–2806.24). In the multivariate logistic regression, we found that an increase in Se of 1 µg/L reduces the risk of GH by 6% (AOR = 0.94; p = 0.004), the risk of IUGR by 11% (AOR = 0.89; p = 0.013), and the risk of birth <34th week by 7% (but close to the significance) (AOR = 0.93; p = 0.061). An increase in Fe of 100 µg/L reduces the risk of PE by 27% (AOR = 0.73; p = 0.009). In the multivariable linear regression, we found negative strong associations between prepregnancy BMI, Se (β = −0.130; p = 0.002), and Fe (β = −0.164; p < 0.0001), but positive associations with Cu (β = 0.320; p < 0.000001). The relationships between Se and maternal age (β = 0.167; p < 0.0001), Se and smoking (β = −0.106; p = 0.011) and Cu, and gestational age from the 10–14th week (β = 0.142; p < 0.001) were also found. Secondary education was associated with Zn (β = 0.132; p = 0.004) and higher education was associated with Cu (β = −0.102; p = 0.023). A higher financial status was associated with Fe (β = 0.195; p = 0.005). Other relationships were statistically insignificant. Further research is needed to clarify relationships between first trimester microelements and pregnancy complications. In addition, attention should be paid to lifestyle-related and socioeconomic factors that affect microelement levels.

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“…Although the exact mechanisms linking environmental factors to thyroid autoimmunity are not as yet fully understood, there is increasing evidence that the following environmental factors are involved in development of autoimmune diseases: environmental pollution (e.g., organochlorines and pesticides), nutrients with iodine, Se, iron, zinc, vitamin B12, and D, irradiation, drugs (interferon α and γ, TNF-α), smoking, obesity, socioeconomic status, infections, stress, lifestyle, and pregnancy [30]. Recently published data from Australia showed that lower plasma copper measured at pregnancy week 15, even though adjusted to Se and zinc status, had decreased the risk of any pregnancy complications [31]. The authors concluded that further research to determine the role of trace elements in early pregnancy should specifically focus on their interactions in supporting fetal development and pregnancy outcome.…”

Section: Se Sources and Daily Requirement In Pregnancymentioning

confidence: 99%

Pregnancy, thyroid, and the potential use of selenium

Hubalewska‐Dydejczyk

Duntas²,

Gilis‐Januszewska

2019

Hormones

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The management of pregnant women is a major concern of health care around the world. There is growing evidence regarding the influence of selenium (Se) on pregnancy and fetus outcomes. However, due to as yet insufficient evidence, lack of measurable markers to assess the effect of Se supplementation on the human metabolism, and Se's narrow therapeutic index, the majority of experts and the current guidelines published by several scientific societies do not recommend the use of Se in pregnancy and in women of childbearing age. Further research based on well-designed studies, including assessment of the complex interactions between different micronutrients and individual response to different doses of Se, is needed.

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Early pregnancy maternal trace mineral status and the association with adverse pregnancy outcome in a cohort of Australian women

Cited by 71 publications

References 44 publications

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Pregnancy, thyroid, and the potential use of selenium

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