Early quality of life outcomes after surgery in head and neck cancer survivors with EORTC QLQ-C30 and EORTC QLQ-HN35 in an Asian tertiary centre

Kao, Nern Hoong; Iyer, N. Gopalakrishna; Chua, Alice Foong Sin; Nagadia, Rahul Harshad

doi:10.1007/s00520-022-06871-4

Cited by 4 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kao got 67.9 ± 14.8, Hammerlid 73.2 ± 21.3 and Liao 70.9 ± 22.1. [21][22][23] Among the five functional aspects, the aspect that is most affected is role function. Role function is the patient's ability to carry out daily activities, hobby activities, and work or profession.…”

Section: Discussionmentioning

confidence: 99%

“…The study by Kao et al did not find a significant association, but a study by Liao et al found that patients with high socioeconomic status had better functioning effects. 21,22 Janda M et al observed that high levels of education and marital status were associated with better functioning and quality of life. 28 The EORTC QLQ C30 symptom scale in this study showed an average score of ≤50.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The ACUTE SIDE EFFECTS AND QUALITY OF LIFE IN HEAD AND NECK CANCER PATIENTS WHO UNDERWENT RADIOTHERAPY IN BALI, INDONESIA

Sukarno,

Ganapati,

Deantri

2024

eum

View full text Add to dashboard Cite

Latar Belakang: Radioterapi merupakan modalitas terapi kanker kepala dan leher yang membunuh sel kanker dengan gelombang radiasi. Selain merusak sel kanker, radioterapi juga merusak sel tubuh yang sehat di sekitar jaringan target. Kerusakan sel-sel tubuh yang sehat menyebabkan efek samping toksisitas dari radioterapi. Efek samping radioterapi menyebabkan penurunan kualitas hidup pada pasien yang menjalani radioterapi. Seiring kemajuan teknologi, ada banyak jenis alat teleterapi yang dikembangkan. Tujuan : Penelitian ini bertujuan untuk membandingkan efek samping akut dan kualitas hidup pasien yang menjalani radioterapi dengan peralatan yang berbeda; Cobalt-60 dan LINAC (Akselerator Linear). Pasien dan Metode : Penelitian observasional analitik, dilakukan pada pasien kanker kepala dan leher yang menjalani radioterapi antara Januari 2020 dan Juli 2022 di bagian radioterapi, RSUP Prof. Dr. IGNG Ngoerah , Bali . Kami mengukur kualitas hidup pasien dengan kuesioner EORTC QLQ-C30 dan efek samping akut dengan penilaian RTOG. Nilai rata-rata dan perbandingan kedua alat teleterapi dinilai menggunakan tabulasi silang dan dianalisis dengan Statistical Package for Social Science (SPSS) versi 26.0. Hasil : Penelitian ini menerima 52 pasien (35 LINAC dan 17 Cobalt-60) yang memenuhi kriteria inklusi dan eksklusi. Partisipan penelitian ini sebagian besar berusia 49-60 tahun (50%), berjenis kelamin laki-laki (63,7%), lokasi kanker utama di nasofaring (84,6%), dan stadium prognosis 4A (57,7%). Perbandingan antara kedua kelompok menunjukkan nilai p >0,05 pada efek samping akut dan kualitas hidup. Sebagian besar pasien mengalami efek samping RTOG Tingkat 1 pada kulit, kelenjar ludah, faring dan esofagus, serta laring. Kelompok LINAC memiliki persentase yang lebih tinggi (94,3%) dari kondisi umum "baik" dibandingkan dengan kelompok Cobalt 60 (76,5%). Skala fungsi terendah berdasarkan EORTC QLQ-C30 adalah fungsi peran (51,9 ± 31,8), dan skor skala gejala tertinggi adalah kelelahan (50,0 ± 31,2). Kesimpulan : Tidak terdapat perbedaan bermakna efek samping akut dan kualitas hidup pasien yang menjalani radioterapi dengan teleterapi LINAC dan Cobalt-60. Namun, kelompok LINAC memiliki persentase kondisi umum “baik” yang lebih besar dibandingkan dengan kelompok Cobalt-60. Kata kunci: Cobalt-60, LINAC, Efek Samping Akut, Kualitas Hidup, Radioterapi.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The ACUTE SIDE EFFECTS AND QUALITY OF LIFE IN HEAD AND NECK CANCER PATIENTS WHO UNDERWENT RADIOTHERAPY IN BALI, INDONESIA

Sukarno,

Ganapati,

Deantri

2024

eum

View full text Add to dashboard Cite

show abstract

The therapeutic efficacy of different configuration nano-polydopamine drug carrier systems with photothermal synergy against head and neck squamous cell carcinoma

Guo,

Li,

Xie

et al. 2024

Regenerative Biomaterials

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor worldwide. Considering its special anatomical site and the progressive resistance to chemotherapy drugs, the development of more effective, minimally invasive, and precise treatment methods is urgently needed. Nanomaterials, given their special properties, can be used as drug carrier systems to improve the therapeutic effect and reduce the adverse effects. The drug carrier systems with photothermal effect can promote the killing of cancer cells and help overcome drug resistance through heat stress. We selected dopamine, a simple raw material, and designed and synthesized three different configurations of nano-polydopamine (nPDA) nanomaterials, including nPDA balls, nPDA plates, and porous nPDA balls. In addition to the self-polymerization and self-assembly, nPDA has high photothermal conversion efficiency and can be easily modified. Moreover, we loaded cisplatin into three different configurations of nPDA, creating nPDA-cis (the nano-drug carrier system with cisplatin), and comparatively studied the properties and antitumor effects of all the nPDA and nPDA-cis materials in vitro and nPDA-cis in vivo. We found that the photothermal effect of the nPDA-cis balls drug carrier system had synergistic effect with cisplatin, resulting in excellent antitumor effect and good clinical application prospects. The comparison of the three different configurations of drug carrier systems suggested the importance of optimizing the spatial configuration design and examining the physical and chemical properties in the future development of nano-drug carrier systems. In this study, we also noted the duality and complexity of the influences of heat stress on tumors in vitro and in vivo. The specific mechanisms and the synergy with chemotherapy and immunotherapy will be an important research direction in the future.

show abstract

Health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers

Sheida,

Abbasi,

Ameri

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective: This study aimed to assess health-related quality of life (HRQoL) and cancer-related fatigue (CRF) in patients with non-metastatic head and neck cancers over a six-month period following treatment initiation. Methods: Patients with non-metastatic head and neck cancers referring to two oncology clinics in Hamadan, Iran, from April 2022 to March 2023 were evaluated using the Brief Fatigue Inventory (BFI) and the European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ C-30) version 3. Scores were recorded at baseline and six-month post-treatment. All statistical analyses were performed using SPSS version 27, with a P-value of <0.05 considered statistically significant. Results: Of the 47 patients in this study, 83% were male (n=39) and the mean age was 54.28±9.61 years. The oral cavity (n=25, 53.2%) and larynx (n=11, 23.4%) were the most frequent tumor sites. Significant increase in CRF were observed between baseline and six-month post-treatment (3.07 vs. 3.50, P <0.001). The result of EORTC QLQ C-30 showed that mean global QoL score was 73.91±8.89 at baseline and 63.40±9.20 six-month post-treatment (P<0.001). The majority of functional scales items reduced significantly (P<0.001), and symptom scale items increased over time. Conclusion: In conclusion, this study demonstrates a significant decline in QoL and an increase in CRF among patients with non-metastatic head and neck cancers during the first six months of treatment. The findings emphasize the multifactorial impact of cancer treatments on physical, psychological, and financial aspects of patients’ life and vital need for supportive care.

show abstract

Early quality of life outcomes after surgery in head and neck cancer survivors with EORTC QLQ-C30 and EORTC QLQ-HN35 in an Asian tertiary centre

Cited by 4 publications

References 20 publications

The ACUTE SIDE EFFECTS AND QUALITY OF LIFE IN HEAD AND NECK CANCER PATIENTS WHO UNDERWENT RADIOTHERAPY IN BALI, INDONESIA

The ACUTE SIDE EFFECTS AND QUALITY OF LIFE IN HEAD AND NECK CANCER PATIENTS WHO UNDERWENT RADIOTHERAPY IN BALI, INDONESIA

The therapeutic efficacy of different configuration nano-polydopamine drug carrier systems with photothermal synergy against head and neck squamous cell carcinoma

Health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers

Contact Info

Product

Resources

About