Early recovery of botulism: one decade of experience

Hatami, Firouze; Shokouhi, Shervin; Mardani, Masoud; Shabani, Minoush; Gachkar, Latif; Darazam, Ilad Alavi

doi:10.1080/15563650.2020.1844225

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Dependent on the quantity and serotype of the causative BoNT, recovery from the condition can range from a few weeks to several months. With prompt treatment and administration of the antitoxin, a full recovery can occur in as little as two weeks with no lasting symptoms [ 128 , 163 ]. Recovery from intoxication and restoration of neurotransmitter release is a consequence of the natural protein turnover causing degradation of the BoNT in the neuronal termini and the regeneration of nerve endings from the intoxicated neuron [ 164–167 ].…”

Section: Treatment Of Botulismmentioning

confidence: 99%

Pathogenicity and virulence of Clostridium botulinum

Rawson,

Dempster,

Humphreys

et al. 2023

Virulence

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Clostridium botulinum , a polyphyletic Gram-positive taxon of bacteria, is classified purely by their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor and the causative agent of botulism. A potentially fatal disease, botulism is classically characterized by a symmetrical descending flaccid paralysis, which is left untreated can lead to respiratory failure and death. Botulism cases are classified into three main forms dependent on the nature of intoxication; foodborne, wound and infant. The BoNT, regarded as the most potent biological substance known, is a zinc metalloprotease that specifically cleaves SNARE proteins at neuromuscular junctions, preventing exocytosis of neurotransmitters, leading to muscle paralysis. The BoNT is now used to treat numerous medical conditions caused by overactive or spastic muscles and is extensively used in the cosmetic industry due to its high specificity and the exceedingly small doses needed to exert long-lasting pharmacological effects. Additionally, the ability to form endospores is critical to the pathogenicity of the bacteria. Disease transmission is often facilitated via the metabolically dormant spores that are highly resistant to environment stresses, allowing persistence in the environment in unfavourable conditions. Infant and wound botulism infections are initiated upon germination of the spores into neurotoxin producing vegetative cells, whereas foodborne botulism is attributed to ingestion of preformed BoNT. C. botulinum is a saprophytic bacterium, thought to have evolved its potent neurotoxin to establish a source of nutrients by killing its host.

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Section: Treatment Of Botulismmentioning

confidence: 99%

Pathogenicity and virulence of Clostridium botulinum

Rawson,

Dempster,

Humphreys

et al. 2023

Virulence

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show abstract

“…Las técnicas no invasivas como las inyecciones de toxina botulinica tipo A están creciendo en popularidad debido a sus beneficios de recuperación rápida. Hatami et al (8) discuten cómo las innovaciones han permitido que estos procedimientos sean seguros y con tiempos de inactividad reducidos, lo cual los hace atractivos para los pacientes. Adicionalmente, Moore et al (9) indican que la recuperación rápida después de procedimientos estéticos ofrece beneficios como menos interrupciones en sus vidas diarias, minimizan el estrés asociado con el cuidado prolongado post-procedimiento, el sentir menos dolor y malestar, lo que mejora la satisfacción general del paciente con el procedimiento.…”

Section: Introductionunclassified

Aesthetic Interventions: A Clinical Study on Satisfaction with Personal Appearance

Bunces Larco,

Villegas Chávez,

Posso Pacheco

et al. 2024

Salud, Ciencia y Tecnología

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Aesthetics and the perception of beauty have significantly impacted cultural and personal norms over time. Technological advances in aesthetic medicine have made altering physical appearance more accessible, popularizing procedures such as botulinum toxin and chemical peeling. The aim of this article was to determine patient satisfaction with their personal appearance after undergoing various aesthetic procedures, as well as specific improvements in different areas of the face and skin. The methodology used was a cross-sectional descriptive study involving 67 patients at the "ESTICCA" Aesthetic Medical Center, analyzing demographic and psychosocial aspects through surveys, with data processed in SPSS software for statistical analysis, including Chi-square tests. The results obtained showed that the majority of the patients in the study experienced an increase in satisfaction with their appearance after aesthetic procedures, with significant improvements in specific areas of the face. In conclusion, it was suggested that aesthetic interventions improve not only physical appearance but also psychological and emotional well-being, highlighting the need for a holistic approach in aesthetic medicine.

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Discovery of a Potent Botulinum Neurotoxin A Inhibitor ZM299 with Effective Protections in Botulism Mice

Wang

Luo

et al. 2021

Chin. J. Chem.

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Comprehensive Summary Botulinum neurotoxins serotype A (BoNT/A) is the deadliest toxins known to humans and the "Category A" agent for bioterrorism. Over the past 20 years, significant efforts have been put forth to develop effective inhibitors of BoNT/A. Unfortunately, few identified inhibitors possess noteworthy efficacy against BoNT/A in vivo. Here, we performed a high‐throughput virtual screening based on the structure‐based docking simulations and found a novel potent scaffold 2‐thionicotinate that inhibits the BoNT/A light chain (LC). We then synthesized and optimized a novel series of 2‐thionicotinate derivatives and comprehensively evaluated their activity against BoNT/A in vitro and in vivo. An optimized compound ZM299 effectively exhibits anti‐BoNT/A activity in primary neurons and displayed remarkably therapeutic efficacy against BoNT/A in vivo, which could raise the survival rate of intoxicated mice to 100% (12/12) after lethal doses of BoNT/A exposures. These findings demonstrate that 2‐thionicotinates is a promising scaffold for producing more effective anti‐BoNT/A analogs, and compound ZM299 is worthy of further preclinical evaluation as a drug candidate for the treatment of botulism.

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Early recovery of botulism: one decade of experience

Cited by 5 publications

References 20 publications

Pathogenicity and virulence of Clostridium botulinum

Pathogenicity and virulence of Clostridium botulinum

Aesthetic Interventions: A Clinical Study on Satisfaction with Personal Appearance

Discovery of a Potent Botulinum Neurotoxin A Inhibitor ZM299 with Effective Protections in Botulism Mice

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