Early-stage dysfunction of hippocampal theta and gamma oscillations and its modulation of neural network in a transgenic 5xFAD mouse model

Wang, Sitong; Li, Kai; Zhao, Shaokai; Zhang, Xiaochen; Yang, Zhuo; Zhang, Jianhai; Zhang, Tao

doi:10.1016/j.neurobiolaging.2020.05.002

“…observed in the HPC (Goutagny et al, 2013;Ahnaou et al, 2017;Michels et al, 2017;Bazzigaluppi et al, 2018;Wang et al, 2020a) and the EC of various rodent models of AD (Nakazono et al, 2017). The oscillatory disturbances can be causes of cognitive disturbances of AD patients because these oscillations are essential for memory encoding and retrieval.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

“…Oscillatory disturbances in the brain have been characterized in AD patients (e.g., decrease of high-frequency components, including gamma-band oscillations). Disruptions of theta oscillations, gamma oscillations and theta–gamma cross-frequency phase–amplitude coupling are commonly observed in the HPC ( Goutagny et al, 2013 ; Ahnaou et al, 2017 ; Michels et al, 2017 ; Bazzigaluppi et al, 2018 ; Wang et al, 2020a ) and the EC of various rodent models of AD ( Nakazono et al, 2017 ). The oscillatory disturbances can be causes of cognitive disturbances of AD patients because these oscillations are essential for memory encoding and retrieval.…”

Section: The Medial Septum As a Target For Deep Brain Stimulation For Epilepsy Control And Beyondmentioning

confidence: 99%

The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies

Takeuchi

¹

,

Nagy

²

,

Barcsai

³

et al. 2021

Front. Neural Circuits

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The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Accumulating evidence points out that the physiological oscillations under septal influence are frequently disrupted or altered in pathological conditions. Therefore, the MS may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies) to restore healthy patterns or erase undesired ones. Recent studies have revealed that the patterned stimulation of the MS alleviates symptoms of epilepsy. We discuss here that stimulus timing is a critical determinant of treatment efficacy on multiple time scales. On-demand stimulation may dramatically reduce side effects by not interfering with normal physiological functions. A precise pattern-matched stimulation through adaptive timing governed by the ongoing oscillations is essential to effectively terminate pathological oscillations. The time-targeted strategy for the MS stimulation may provide an effective way of treating multiple disorders including Alzheimer’s disease, anxiety/fear, schizophrenia, and depression, as well as pain.

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“…decrease of high-frequency components, including gamma-band oscillations). Disruptions of theta oscillations, gamma oscillations and thetagamma cross-frequency phase-amplitude coupling are commonly observed in the HPC (Goutagny et al, 2013;Ahnaou et al, 2017;Michels et al, 2017;Bazzigaluppi et al, 2018;Wang et al, 2020a) and the EC of various rodent models of AD (Nakazono et al, 2017). The oscillatory disturbances can be causes of cognitive disturbances of AD patients because these oscillations are essential for memory encoding and retrieval.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

The Medial Septum as a Potential Target for Treating Brain Disorders Associated with Oscillopathies

Takeuchi

¹

,

Nagy

²

,

Barcsai

³

et al. 2021

Preprint

View full text Add to dashboard Cite

The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Accumulating evidence points out that the physiological oscillations under septal influence are frequently disrupted or altered in pathological conditions. Therefore, the MS may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies) to restore healthy patterns or erase undesired ones. Recent studies have revealed that the patterned stimulation of the MS alleviates symptoms of epilepsy. We discuss here that stimulus timing is a critical determinant of treatment efficacy on multiple time scales. On-demand stimulation may dramatically reduce side effects by not interfering with normal physiological functions. A precise pattern-matched stimulation through adaptive timing governed by the ongoing oscillations is essential to effectively terminate pathological oscillations. The time-targeted strategy for the MS stimulation may provide an effective way of treating multiple disorders including Alzheimer’s disease, anxiety/fear, schizophrenia, and depression, as well as pain.

show abstract

“…Flicker stimulation at 40 Hz reduced Aβ in multiple mouse models, including 5 × FAD, APP/PS1, and WT mice, and reduced phosphorylated tau staining in a mouse model of tauopathy, TauP301S, showing that the protective effects of gamma stimulation can be generalized to other pathogenic proteins [ 80 ]. The rhythmic oscillations of theta and gamma rhythmic oscillation in mice were restored, and the activity of GABAergic neurons was increased [ 81 ].…”

Section: Neurotransmitter Abnormalities and Cognitive Dysfunctionmentioning

confidence: 99%

Neurotransmitters in Prevention and Treatment of Alzheimer’s Disease

Yang

¹

,

Zou

²

,

Wang

³

2023

IJMS

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Alzheimer’s disease (AD) is the most frequent cause of cognitive impairment in middle-aged and older populations. There is a lack of drugs that demonstrate significant efficacy in AD, so the study of the pathogenesis of AD is of great importance. More efficacious interventions are needed, as reflected by our population’s fast aging. Synaptic plasticity is the capacity of neurons to adjust their connections, and it is strongly tied to learning and memory, cognitive function, and brain injury recovery. Changes in synaptic strength, such as long-term potentiation (LTP) or inhibition (LTD), are thought to represent the biological foundation of the early stages of learning and memory. The results of numerous studies confirm that neurotransmitters and their receptors play an important role in the regulation of synaptic plasticity. However, so far, there is no definite correlation between the function of neurotransmitters in aberrant neural oscillation and AD-related cognitive impairment. We summarized the AD process to understand the impact of neurotransmitters in the progression and pathogenesis of AD, including the current status of neurotransmitter target drugs, and the latest evidence of neurotransmitters’ function and changes in the AD process.

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Early-stage dysfunction of hippocampal theta and gamma oscillations and its modulation of neural network in a transgenic 5xFAD mouse model

Cited by 27 publications

References 41 publications

The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies

The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies

The Medial Septum as a Potential Target for Treating Brain Disorders Associated with Oscillopathies

Neurotransmitters in Prevention and Treatment of Alzheimer’s Disease

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