Early stage epithelial ovarian cancers: A study of morphologic prognostic factors

Terzi, Ayşen; Aktaş, Isıl Yıldız; Dolgun, Anıl; Ayhan, Ali; Küçükali, T.; Usubütün, Alp

doi:10.1016/j.prp.2013.03.009

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…But it was lower than other previous reports (11.2-29%) [13,14,25,26,27]. This variability may be the result of an under detection or missing reports of endometriosis in some centers, but a recent systematic review by Heidemann et al [28] shows that some studies include all types of EOCs and others only determined subtypes as endometrioid, clear cell, I-stage cases [29] (52.6%), or early stages [30] (23.7%). In fact, the association of endometriosis with EOC is more frequently found in early stages and in determined histological types, mainly endometrioid and clear cell carcinomas, although there is also a difference in results on the latter.…”

Section: Discussionmentioning

confidence: 99%

Epithelial Ovarian Cancers and Endometriosis

Acién

Velasco²,

Acién³

et al. 2015

Gynecol Obstet Invest

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Aims: To determine the prevalence of endometriosis in epithelial ovarian cancers (EOC) and the association among their histological subtypes and with endometrial carcinoma. Methods: An observational cohort study performed in 192 patients operated on for EOC, 30 women with atypical endometriosis and 17 with p53 positive endometriosis. Data on associated endometriosis and endometrial carcinomas, histological subtypes, tumor stage, clinical and pathological characteristics and survival were analyzed. Results: Twenty cases of EOC (10.4%) had also endometriosis (12.7 in borderline and 9.3% in invasive cases), being a synchronous finding in most cases. Endometriosis associated with serous or mucinous EOC was observed in 2.2 and 2.7% of cases, respectively. However, this association was observed in 50 of endometrioid and 23% of clear cell EOC. Age, parity and tumor stage were lower in endometriosis-associated EOC patients; and all associated cases were type I (Kurman and Shih's classification) and showed better results in survival rate. Endometrial carcinoma was more frequently associated with endometrioid EOC (25%). Conclusions: There is a significant association between endometriosis, including atypical forms, and endometrioid and clear cell carcinomas, but not with other EOC histotypes. The presence of endometriosis in EOC suggests a better prognosis and an intermediate stage within the progression endometriosis-carcinoma.

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Section: Discussionmentioning

confidence: 99%

Epithelial Ovarian Cancers and Endometriosis

Acién

Velasco²,

Acién³

et al. 2015

Gynecol Obstet Invest

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“…Although progress has been made in diagnostics and treatments of ovarian cancer, the prognosis of ovarian cancer patients is far from optimistic [ 2 , 3 ]. The International Federation of Gynecology and Obstetrics (FIGO) stage, histotype and grade of differentiation are recognized as classical prognostic factors, but they cannot accurately predict the prognosis of ovarian cancer [ 4 , 5 ]. However, studies have proved that many biomarkers are involved in the progression of ovarian cancer [ 6 ], identification and validation of prognostic factors can complement well-established clinical histopathology analysis with the aim of improving future treatments [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

An updated meta-analysis of the prognostic value of decreased E-cadherin expression in ovarian cancer

Hua

et al. 2017

Oncotarget

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Decreased epithelial cadherin (E-cadherin) expression is hypothesized to be related to poor prognosis of ovarian cancer, but the predictive value is still inconsistent. We conducted an updated meta-analysis with a total of 16 studies enrolling 1720 patients to estimate the prognostic value of decreased E-cadherin expression in ovarian cancer. Reduced expression of E-cadherin was significantly associated to poor overall survival (HR = 1.74, 95% CI: 1.40–2.17) and progression-free survival (HR = 1.45, 95% CI: 1.12–1.86) with a large heterogeneity for overall survival. In addition, we found that decreased expression of E-cadherin was significantly correlated with International Federation of Gynecology and Obstetrics grade (HR = 3.74, 95% CI: 2.24–6.23), E-cadherin membranous (HR = 1.47, 95% CI: 1.01–2.14), pathologic grade (HR = 1.41, 95% CI: 1.01–1.97), residual tumor size (HR = 2.72, 95% CI: 1.99–3.72), and surgery (HR = 3.21, 95% CI: 1.19–8.67). Our finding suggests that decreased E-cadherin expression may be a predictor of poor ovarian cancer prognosis.

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