Early-stage inflammation changes in supraspinatus muscle after rotator cuff tear

Stengaard, Kira; Hejbøl, Eva Kildall; jensen, Peter Toft; Degn, Matilda; Ta, Thi My Linh; Stensballe, Allan; Andersen, Ditte Caroline; Lambertsen, Kate Lykke; Frich, Lars Henrik

doi:10.1016/j.jse.2021.12.046

Cited by 14 publications

(10 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After rotator cuff injury, the local inflammatory exudation of the shoulder joint causes pain in the shoulder joint, which in turn affects joint activities and significantly impacts work and life. [9,14] It is generally believed that arthroscopic rotator cuff repair is a minimally invasive surgery with less bleeding. Kawaguchi et al [15] reported the average blood loss of the arthroscopic rotator to be 355.5 ± 191.2 mL during arthroscopic rotator cuff repair.…”

Section: Discussionmentioning

confidence: 99%

“…Due to its nature of minimally invasive surgery with less trauma, less bleeding, and faster recovery, arthroscopic rotator cuff repair surgery has now become a common surgical approach to repair rotator cuff injuries. [ 9 ] The surgical field of vision and anatomical structure is more evident than in open surgery. At the same time, due to the magnifying effect of arthroscopy, delicate operations can be performed under the microscope, reducing the damage to the unnecessary surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of risk factors for procedure-related hemorrhage in rotator cuff repair surgery under shoulder arthroscopy

Guo,

Wang

2023

Medicine

View full text Add to dashboard Cite

The present study aims to validate the methods of quantifying blood loss in arthroscopic rotator cuff repair and to investigate the correlation between blood loss and joint pain and joint function recovery. A total of 38 patients with unilateral rotator cuff injuries who underwent shoulder arthroscopy were analyzed in this study. Related information, including age, gender, blood pressure, body mass index (BMI), disease entity, comorbidity, joint release, and operating time, were collected into a spreadsheet. Serum hemoglobin and hematocrit (HCT) levels were obtained before the surgery and on the first and third days after the operation. The visual analog scale (VAS) score and the constant-Murley score of the shoulder joint were evaluated 1 year after the operation. Preoperative blood volume (PBV), red blood cell (RBC), hemoglobin (Hb), and HCT levels were significantly higher than those on postoperative day 1 and day 3. The average surgery-related blood loss was calculated to be 435.2 ± 53.6 mL during the surgery and the first postoperative day and 542.5 ± 63.0 mL during the surgery and the first 3 days after the surgery. The VAS score was significantly reduced 1 year after surgery. The multivariate linear regression analysis showed that joint release was a potential risk factor for predicting blood loss 1 or 3 days postoperatively. The actual blood loss from shoulder arthroscopy may be underestimated. The joint release was regarded as the leading risk factor for blood loss.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of risk factors for procedure-related hemorrhage in rotator cuff repair surgery under shoulder arthroscopy

Guo,

Wang

2023

Medicine

View full text Add to dashboard Cite

show abstract

“…In these RC tears, FI is an irreversible, muscle degenerative change that results in muscle weakness, shoulder dysfunction, limited range of motion, and impaired tendon-bone healing [6,7] Massive RC tears induce an in ammatory response in muscles and can have detrimental effects on the development of chronic diseases, leading to muscle atrophy and FI of the skeletal muscles [8][9][10][11]. Previous studies have suggested that the RC muscle becomes in amed in the presence of an RC tendon tear [12]. and that this acute in ammation plays a detrimental role in the development of chronic muscle diseases [7,13].…”

mentioning

confidence: 99%

“…and that this acute in ammation plays a detrimental role in the development of chronic muscle diseases [7,13]. In an actual animal experiment, the number of in ammatory cells such as neutrophils and monocytes/macrophages peaked at the rst 5-7 days in the SS muscles with ruptured full-thickness RC tendons, and signi cant changes were noted in proin ammatory and anti-in ammatory cytokines [5,12,14,15]. Clinical studies have also reported muscle changes and overall changes in cytokine levels, metalloprotease levels, and growth factors after RC tendon rupture [16].…”

mentioning

confidence: 99%

Metformin increases the expression of proinflammatory cytokines and inhibits supraspinatus fatty infiltration

Yoon

Park

Kim

et al. 2023

Preprint

View full text Add to dashboard Cite

Background After a rotator cuff (RC) tendon tear, the supraspinatus (SS) inflammatory response induces fatty infiltration (FI). Metformin has the effect of regulating the initial inflammatory response of atrophic muscles. Therefore, this study aimed to investigate the effect of metformin use on modulating the expression of proinflammatory cytokines and SS FI in an acute RC tear rat model. Methods This study used 26 male Sprague–Dawley rats. Animals were randomly divided into two groups: The metformin group received metformin for 5 days after cutting the RC tendon, and the control group was administered only with saline after cutting the tendon. Metformin 50 mg/kg was intraperitoneally injected for 5 days. Three rats in each group were sacrificed 5 days after SS tendon rupture surgery, and 10 rats in each group were sacrificed 14 days after surgery. The SS was sampled 5 days after SS tendon tear surgery, and the expression of proinflammatory cytokines was measured by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). On day 14 after sampling, histological analysis of the SS was performed using hematoxylin and eosin, Masson’s trichrome, and picosirius red staining. Results On day 5 of surgery, the expression values of interferon gamma (increased 7.2-fold, P < .01), tumor necrosis factor alpha (increased 13-fold, P < .05), interleukin-1β (increased 4.7-fold, P < .001), and interleukin-6 (increased 4.6-fold, P < .01) increased significantly in the metformin group compared with those in the control group. As a result of Oil Red O staining, SS FI was significantly suppressed in the metformin group compared with that in the control group (metformin group, 305 ± 50.3 µm2, P < .001; control group, 3136 ± 662.8 µm2, P < .001). In addition, the SS volume of the metformin group was not reduced compared with those of the control group, and the morphology and structure of the SS were better preserved. Conclusions The results of this study revealed that metformin can increase the expression of proinflammatory cytokines and suppress SS fat infiltration in delayed sutures.

show abstract

“…It has been shown that rotator cuff tearing is characterized by intra-articular inflammation and subacromial bursitis and that an inverse correlation exists between the severity of the inflammation and the tendon tear size. 11 , 12 , 13 , 14 , 15 , 16 The purpose of this study was to determine whether the intra-articular temperature of the shoulder correlates with the size of the tendon tear in patients with rotator cuff tears (RCTs). We hypothesized that small rotator cuff tendon tears would have higher shoulder intra-articular temperatures than large and massive tears.…”

mentioning

confidence: 99%

Shoulder Intra-Articular Temperature Is Higher In Patients With Small Rotator Cuff Tears Compared With Patients Who Have Larger Tears

Gumina,

Rionero,

Preziosi Standoli

et al. 2023

Arthroscopy, Sports Medicine, and Rehabilitation

View full text Add to dashboard Cite

Early-stage inflammation changes in supraspinatus muscle after rotator cuff tear

Cited by 14 publications

References 45 publications

Analysis of risk factors for procedure-related hemorrhage in rotator cuff repair surgery under shoulder arthroscopy

Analysis of risk factors for procedure-related hemorrhage in rotator cuff repair surgery under shoulder arthroscopy

Metformin increases the expression of proinflammatory cytokines and inhibits supraspinatus fatty infiltration

Shoulder Intra-Articular Temperature Is Higher In Patients With Small Rotator Cuff Tears Compared With Patients Who Have Larger Tears

Contact Info

Product

Resources

About