2011
DOI: 10.1212/01.wnl.0000407773.70404.5e
|View full text |Cite
|
Sign up to set email alerts
|

Early stroke treatment associated with better outcome: the ninds rt-pa stroke study

Abstract: and for the NINDS rt-PA Stroke Study Group Neurology 2000;55:1649-1655Background: The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study showed a similar percentage of intracranial hemorrhage and good outcome in patients 3 months after stroke treatment given 0 to 90 minutes and 91 to 180 minutes after stroke onset. At 24 hours after stroke onset more patients treated 0 to 90 compared to 91 to 180 minutes after stroke onset had improved by four or more points on the NIH Stroke Sc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

3
172
0
14

Year Published

2011
2011
2017
2017

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 151 publications
(189 citation statements)
references
References 0 publications
3
172
0
14
Order By: Relevance
“…Reduced knowledge and awareness of stroke is associated with delay in obtaining urgent medical attention (40,44,45), which in turn is associated with negative clinical outcomes (4,5). Inability to identify and respond to stroke could delay medical intervention and have far-reaching economic impact on the direct and indirect costs (7,46,47) seeking urgent medical attention in the instance of stroke, it is of concern that a high proportion of respondents were unable to define key symptoms of stroke.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Reduced knowledge and awareness of stroke is associated with delay in obtaining urgent medical attention (40,44,45), which in turn is associated with negative clinical outcomes (4,5). Inability to identify and respond to stroke could delay medical intervention and have far-reaching economic impact on the direct and indirect costs (7,46,47) seeking urgent medical attention in the instance of stroke, it is of concern that a high proportion of respondents were unable to define key symptoms of stroke.…”
Section: Discussionmentioning
confidence: 99%
“…New Zealand has the second highest age-adjusted incidence of stroke among developed countries (3). When stroke occurs, early detection and treatment are critical in reducing the risk of disability and death (4). Early recognition and urgent transfer to stroke centres to ensure patients receive medical treatment within hours of stroke onset significantly improves survival rates (5).…”
Section: Introductionmentioning
confidence: 99%
“…[4][5][6] The benefit is markedly time-dependent and wanes within hours of stroke ictus, reflecting a progression of irreparable core infarction and increasing the risk of hemorrhagic transformation. [7][8][9][10] The American Heart Association/American Stroke Association (AHA/ASA) guidelines for early management of AIS reflect the central importance of early thrombolysis; tPA administration is recommended within 4.5 hours of symptom onset and within 1 hour of arrival at a hospital. 11 Although early thrombolysis is clearly beneficial, practical challenges persist such that the majority of stroke victims who are eligible for tPA do not receive it within the recommended times.…”
Section: Introductionmentioning
confidence: 99%
“…An interesting observation in the SETI survey is that almost 50% of the patients had a CT scan within 6 hours from the symptoms onset, which is the time window within which a thrombolytic therapy could be still attempted [19][20][21][22]. This might represent an indirect index of the efficiency of the Internal Medicine structures of Tuscany and suggests that thrombolytic therapy could be in the future used to a larger sample of patients and in a wider setting of that currently applied.…”
Section: Discussionmentioning
confidence: 99%