Early symptom-relief after valvulotomy in mitral stenosis indicates role of lobeline-sensitive intrapulmonary receptors

Anand, Ashima; Roy, Ambuj; Bhargava, Balram; Raj, Hans; Barde, Pradip; Vijayan, V K

doi:10.1016/j.resp.2009.09.007

Cited by 12 publications

(5 citation statements)

References 33 publications

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Section: Discussionmentioning

confidence: 99%

“…Dyspnoea on exertion (DOE) is a common symptom in both HAPE-S and pulmonary hypertension (PH) and associated with simultaneous rise in Ppa and pulmonary capillary wedge pressure (PCWP) 8 38 . Reduction of high PCWP in PH caused significant relief in DOE 38 . Acute hypoxia in HAPE-S induces increase in Ppa, as well as a possible rise in pulmonary capillary wedge pressure due to pulmonary venoconstriction in accordance to previous study 26 39 .…”

Section: Discussionmentioning

confidence: 99%

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Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers

Gupta

Himashree

Singh

et al. 2016

Sci Rep

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Exaggerated pulmonary pressor response to hypoxia is a pathgonomic feature observed in high altitude pulmonary edema (HAPE) susceptible mountaineers. It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of HAPE susceptible subjects in a non-mountaineer population. We studied BNP levels, baseline hemodynamics and the response to hypoxia (FIo2 = 0.12 for 30 min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31 ± 3.63 vs 15.68 ± 2.79 mm Hg, p < 0.05) and plasma BNP levels (52.39 ± 32.9 vs 15.05 ± 9.6 pg/ml, p < 0.05) were high and stroke volume was less (p < 0.05) in HAPE-S subjects compared to control. Acute hypoxia produced an exaggerated increase in heart rate (p < 0.05), mean arterial pressure (p < 0.05) and Ppa (28.2 ± 5.8 vs 19.33 ± 3.74 mm Hg, p < 0.05) and fall in peripheral oxygen saturation (p < 0.05) in HAPE-S compared to control. Receiver operating characteristic (ROC) curves showed that Ppa response to acute hypoxia was the best variable to identify HAPE susceptibility (AUC 0.92) but BNP levels provided comparable information (AUC 0.85). BNP levels are easy to determine and may represent an important marker for the determination of HAPE susceptibility.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers

Gupta

Himashree

Singh

et al. 2016

Sci Rep

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“…East Asian lobelias are traditional medicinal plant species because of their bioactivity and many chemical constituents (Anand et al, 2009;Han et al, 2013;Zheng et al, 2021). However, the scarcity of genomic resources for East Asian lobelias has hampered plant genetics, ecology, taxonomy, and resource utilization.…”

Section: Molecular Markersmentioning

confidence: 99%

Plastome evolution in the East Asian lobelias (Lobelioideae) using phylogenomic and comparative analyses

Xie

Liu

et al. 2023

Front. Plant Sci.

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Lobelia species, as rich source of the alkaloid lobeline which has been shown to have important biological activity, have been used in folk medicine throughout East Asia to treat various diseases. However, Lobelia is a complex and varied genus in East Asia and is thus difficult to identify. Genomic resources would aid identification, however the availability of such information is poor, preventing a clear understanding of their evolutionary history from being established. To close this gap in the available genomic data, in this study, 17 plastomes of East Asian lobelias were newly sequenced and assembled. Although the plastomes of Lobelia sect. Hypsela, L. sect. Speirema, and L. sect. Rhynchopetalum shared the gene structure, the inverted repeat (IR)/large single copy (LSC) boundaries, genome size, and the number of repeats were variable, indicating the non-conservative nature of plastome evolution within these sections. However, the genomes of the Lobelia sect. Delostemon and L. sect. Stenotium showed rearrangements, revealing that these two sections might have undergone different evolutionary histories. We assessed nine hotspot genes and 27-51 simple sequence repeat motifs, which will also serve as valuable DNA barcode regions in future population genetics studies and for the delineation of plant species. Our phylogenetic analysis resolved the evolutionary positions of the five sections in agreement with previous evolutionary trees based on morphological features. Although phylogenetic reconstruction of Lobelioideae based on the rpoC2 gene has rarely been performed, our results indicated that it contains a considerable amount of phylogenetic information and offers great promise for further phylogenetic analysis of Lobelioideae. Our site-specific model identified 173 sites under highly positive selections. The branch-site model exhibited 11 positive selection sites involving four genes in the East Asian branches. These four genes may play critical roles in the adaptation of East Asian taxa to diverse environments. Our study is the first to detect plastome organization, phylogenetic utility, and signatures of positive selection in the plastomes of East Asian lobelias, which will help to further advance taxonomic and evolutionary studies and the utilization of medicinal plant resources.

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“…The characteristic reflexes elicited by these receptors are an acceleration of breathing, inhibition of exercise and bradycardia. These have been demonstrated in animals by intravenous injection of phenyl diguanide [1-6] and in human subjects by intravenous injection of lobeline, a short-acting alkaloid [7][8][9][10][11] is accompanied by a variety of characteristic sensations in the upper chest such as an upward rising pressure from chest to throat, choking, feeling of being short of breath, a desire to cough or an actual cough [7]. These sensations have been shown to be akin to dyspneic sensations of exercising patients of left ventricular dysfunction, mitral stenosis and Eisenmenger syndrome [8,9,11].…”

Section: Acceleration Of Breathing and Respiratory Sensationsmentioning

confidence: 99%

J Receptor Reflexes Terminate Exercise to Reduce Pulmonary Inflow

Anand¹

2023

MJC

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A great increase in ventilation and cardiac output is set off by and even before rapid locomotion begins. An investigation into the neural mechanisms involved revealed that the subsequent increase in pulmonary blood flow stimulates J or juxtapulmonary capillary receptors that lie in the pulmonary parenchyma. Reflexes arising from stimulation of these sensory receptors are an increase in ventilation accompanied by sensations of breathlessness, bradycardia and reduction or stopping of exercise. Of these, the significance of reflex bradycardia is to reduce the great rise in pulmonary capillary pressure during strenuous exercise and protect the pulmonary arterioles from rupture as they are vulnerable to mechanical stress.

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Early symptom-relief after valvulotomy in mitral stenosis indicates role of lobeline-sensitive intrapulmonary receptors

Cited by 12 publications

References 33 publications

Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers

Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers

Plastome evolution in the East Asian lobelias (Lobelioideae) using phylogenomic and comparative analyses

J Receptor Reflexes Terminate Exercise to Reduce Pulmonary Inflow

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