Early turbulence and pulsatile flows enhance diodicity of Tesla’s macrofluidic valve

Nguyen, Quynh M.; Abouezzi, Joanna; Ristroph, Leif

doi:10.1038/s41467-021-23009-y

Cited by 62 publications

(32 citation statements)

References 52 publications

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“…The arrangement may permit the unified system to serve as a fluidic control system acting as an on–off switch, a fluid amplifier, or a fluidic logic gate with analogies in other circulatory systems. Of interest, the intrascleral CDSP loops have properties suggestive of the ability to act like Tesla valves responsive to oscillatory pulsations ( Nguyen et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A Novel Technique Identifies Valve-Like Pathways Entering and Exiting Schlemm’s Canal in Macaca nemestrina Primates With Similarities to Human Pathways

Martin

Johnstone

2022

Front. Cell Dev. Biol.

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Purpose: The aim of the study was 1) to describe a novel combination of techniques that permit immunohistochemistry imaging of Schlemm’s canal inlet (SIV) and outlet (SOV) valve-like structures, 2) to identify tissue-level SIV adhesive relationships linking the trabecular meshwork (TM) to hinged collagen leaflets at the Schlemm’s canal (SC) external wall, and 3) to determine whether the SIV lumen wall’s adhesive vascular markers are similar to those of the SC inner wall endothelium.Materials and Methods: Anterior segments of 16 M. nemestrina primates underwent immunohistochemistry (IHC) labeling. We perfused fluorescent microspheres into 12 of the eyes. Limbal tissues were divided into quadrants, viscoelastic introduced into SC, tissues fixed, immunohistochemistry performed, radial segments cut, tissues clarified, and confocal microscopy performed. Finally, we generated ImageJ 3D projections encompassing the TM, SC, and distal pathways.Results: IHC imaging identified 3D relationships between SIV, collector channel ostia, collector channels (CC), SOV, and intrascleral channels. Imaging depth increased 176.9%, following clarification (p < 0.0001). Imaging demonstrated CD31, collagen type 1 and 4 in the walls of the SIV lumen and more distal pathways. In eight eyes, 384 segments were examined, 447 SIV identified, and 15.4% contained microspheres.Conclusion: Our technique’s imaging depth permitted the identification of SIV linkage between the TM and SOV. We found comparable cell–cell adhesion molecules (CD31) and basement membrane components in the SC inner wall and SIV lumen walls. Recent OCT studies have suggested that SIV tensional relationships may control CC entrance dimensions that regulate distal resistance. Cellular adhesive properties sustain SIV tensional relationships. These SIV cell–cell and cell-basement membrane properties warrant further study because abnormalities could be a factor in the IOP elevation of glaucoma.

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Section: Discussionmentioning

confidence: 99%

A Novel Technique Identifies Valve-Like Pathways Entering and Exiting Schlemm’s Canal in Macaca nemestrina Primates With Similarities to Human Pathways

Martin

Johnstone

2022

Front. Cell Dev. Biol.

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“…The use of passive micromixers is an alternative to increase reaction performance. Several passive micromixer geometries have been broadly studied due to their efficient mixing quality such as the Tesla valve [23][24][25][26], SAR [27][28][29], curved [30,31], and 3D serpentine [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

CFD Analysis and Life Cycle Assessment of Continuous Synthesis of Magnetite Nanoparticles Using 2D and 3D Micromixers

et al. 2022

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Magnetite nanoparticles (MNPs) have attracted basic and applied research due to their immense potential to enable applications in fields as varied as drug delivery and bioremediation. Conventional synthesis schemes led to wide particle size distributions and inhomogeneous morphologies and crystalline structures. This has been attributed to the inability to control nucleation and growth processes under the conventional conditions of bulk batch processes. Here, we attempted to address these issues by scaling down the synthesis process aided by microfluidic devices, as they provide highly controlled and stable mixing patterns. Accordingly, we proposed three micromixers with different channel configurations, namely, serpentine, triangular, and a 3D arrangement with abrupt changes in fluid direction. The micromixers were first studied in silico, aided by Comsol Multiphysics® to investigate the obtained mixing patterns, and consequently, their potential for controlled growth and the nucleation processes required to form MNPs of uniform size and crystalline structure. The devices were then manufactured using a low-cost approach based on polymethyl methacrylate (PMMA) and laser cutting. Testing the micromixers in the synthesis of MNPs revealed homogeneous morphologies and particle size distributions, and the typical crystalline structure reported previously. A life cycle assessment (LCA) analysis for the devices was conducted in comparison with conventional batch co-precipitation synthesis to investigate the potential impacts on water and energy consumption. The obtained results revealed that such consumptions are higher than those of the conventional process. However, they can be reduced by conducting the synthesis with reused micromixers, as new PMMA is not needed for their assembly prior to operation. We are certain that the proposed approach represents an advantageous alternative to co-precipitation synthesis schemes, in terms of continuous production and more homogeneous physicochemical parameters of interest such as size, morphologies, and crystalline structure. Future work should be directed towards improving the sustainability indicators of the micromixers’ manufacturing process.

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“…It is widely used in various fields, including medicine [ 4 ], chemistry [ 5 ], and biomedicine [ 6 ], etc. In recent years, with the vigorous development of microfluidic technology, microfluidic valves have received extensive attention due to their precise control of microfluidics and low-cost fabrication, such as point-of-care tests (POCT) of tumor marker proteins [ 7 ], unidirectional transport of nanofluids [ 8 , 9 , 10 ], sweat collection microdevice for sweat colorimetric (AST) [ 11 ], rapid and accurate antibiotic-susceptibility testing [ 12 ], etc. A compact and efficient MPV is crucial for the precise manipulation of microfluidics, which directly determines the reliability of the detection results of microfluidic chips.…”

Section: Introductionmentioning

confidence: 99%

Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery

Chen

et al. 2022

Micromachines

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A microfluidic passive valve (MPV) is important for precise flow control, and it determines the reliability of the microfluidic system. In this paper, a novel MPV capable of delivering a constant flow rate independently of inlet pressure changes is proposed. The flow rate of the MPV is adjusted by the difference between the fluid force on the upper surface of the valve core and the spring force. The constant flow rate of the MPV is maintained by automatically changing the size of the gap channel formed by the groove on the valve core and the baffle on the valve body. The nearly constant flow rate of the MPV is 6.26 mL/min, with a variation of 6.5% under the inlet pressure varied from 1.25 kPa to 3.5 kPa. In addition, the flow characteristics of the MPV are analyzed by numerical simulation. With the increase in the inlet pressure, the maximum velocity gradually increases, while the increment of the maximum velocity decreases. In the movement process of the valve core, the region of pressure drop becomes larger. This work has a certain reference value for the design and research of the MPVs with high throughput liquid delivery.

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Early turbulence and pulsatile flows enhance diodicity of Tesla’s macrofluidic valve

Cited by 62 publications

References 52 publications

A Novel Technique Identifies Valve-Like Pathways Entering and Exiting Schlemm’s Canal in Macaca nemestrina Primates With Similarities to Human Pathways

A Novel Technique Identifies Valve-Like Pathways Entering and Exiting Schlemm’s Canal in Macaca nemestrina Primates With Similarities to Human Pathways

CFD Analysis and Life Cycle Assessment of Continuous Synthesis of Magnetite Nanoparticles Using 2D and 3D Micromixers

Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery

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