Early warning signals in chemical reaction networks

Maguire, Oliver R.; Wong, Albert S. Y.; Westerdiep, Jan Harm; Huck, Wilhelm T. S.

doi:10.1039/d0cc01010c

Cited by 16 publications

(19 citation statements)

References 32 publications

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“…Nowadays, continuous synthesis, based on mini- and microreaction technologies is a potential methodology for manufacturing high value chemical derivatives and also for the study of open systems at the laboratory bench scale . There are recent reports on this, although not concerned directly with chirality but dealing with complex reaction networks. , For example, in the case of ref , thanks to the possibility to control the open system parameters, autocatalysis amplification and inhibition, bifurcations leading to bistability, and even oscillatory behavior can be soundly studied. These types of bifurcations are, from a fundamental point of view, not different to those expected for SMSB networks: only a reliable spectroscopic detector able to also detect optical polarization properties (see section ) should substitute the simple UV–vis detector system shown in Figure .…”

Section: Spontaneous Mirror Symmetry Breaking In Molecular Solutionsmentioning

confidence: 99%

Spontaneous Deracemizations

et al. 2021

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Spontaneous deracemizations is a challenging, multidisciplinary subject in current chirality research. In the absence of any chiral inductors, an achiral substance or a racemic composition is driven into an enantioenriched or even homochiral state through a selective energy input, e.g., chemical potential, photoirradiation, mechanical grinding, ultrasound waves, thermal gradients, etc. The most prominent examples of such transformations are the Soai reaction and the Viedma deracemization. In this review, we track the most recent developments in this topic and recall that many other deracemizations have been reported for solutions from mesophases to conglomerate crystallizations. A compiled set of simply available achiral organic, inorganic, organometallic, and MOF compounds, yielding conglomerate crystals, should give the impetus to realize new experiments on spontaneous deracemizations. Taking into account thermodynamic constraints, modeling efforts have shown that structural features alone are not sufficient to describe spontaneous deracemizations. As a guideline of this review, particular attention is paid to the physicochemical origin and symmetry requirements of such processes.

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Section: Spontaneous Mirror Symmetry Breaking In Molecular Solutionsmentioning

confidence: 99%

Spontaneous Deracemizations

et al. 2021

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“…Some other areas where EWS framework has shown promise are chemical reaction networks [183], biological systems [184,185], gene expression dynamics [186], and socioecological systems [187,73].…”

Section: Critical Transitions In Engineering Systemsmentioning

confidence: 99%

Early warning signals for critical transitions in complex systems

George¹,

Kachhara²,

Ambika³

2021

Preprint

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In this review, we present the different measures of early warning signals that can indicate the occurrence of critical transitions in complex systems. We start with the mechanisms that trigger critical transitions, how they relate to warning signals and the methods used to detect early warning signals (EWS) for sudden transitions or tipping. We discuss briefly a few applications in real systems in this context, like transitions in ecology, climate and environment, medicine, epidemics, finance and engineering. Towards the end, we mention the issues in detecting EWS in specific applications and our perspective on future trends in this area, especially related to sudden transitions in the dynamics of connected systems on complex networks.

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“…[13][14][15] Gradually, with the emergence of specialized catalysts, sophisticated orchestration of metabolic reaction networks could be facilitated that incorporates single-step biocatalysis to complex cascade reaction networks. [16][17][18][19][20][21][22] Even though extant biology regularly employs enzymes and proteins with hundreds of amino-acid residues to demonstrate the intricate functions, significantly shorter sequences can also feature extremely sophisticated enzyme like traits through systems of interacting molecular ensembles. The systems level holistic approaches to study such minimalistic nano/micro structures can contribute to our understanding of how complex supramolecular structures could have emerged with advanced functions.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] Further, complex yet synchronized chemical transformations, leading to cascade catalysis by minimal catalytic nanoscaffolds have gained traction due to the critical roles they might have played in early metabolism. 16,17 Looking beyond minimal systems that work close to equilibrium, extant enzymes and protein polymers of modern biology exploit energy sources to perform work away from equilibrium with remarkable spatiotemporal control, both via transient catalysis and compartmentalization. [48][49][50][51] In this regard, reports showing the generation of catalytic systems and compartments under non-equilibrium conditions utilizing simple synthetic precursors have attempted to shed light on how bioenergetics played an essential role in chemical evolution.…”

Section: Introductionmentioning

confidence: 99%