This studi aims to exploration of diverse natural sources for potential remedies. Earthworms, often overlooked in the realm of skincare, have gained attention for their potential role in anti-aging treatments. The methodological approach used in this research is systematic review. This research focuses on randomized controlled trials published on the website from 2017 to 2022. Researchers will screen, extract the data, and cross-check the results. This research from Science Direct, ProQuest, CINAH, Pubmed and Clinical Trials.gov. This research will be conducted by collecting and evaluating various relevant literature sources to identify previous research that has been conducted on this topic. The multifaceted benefits they offer, coupled with their regenerative properties, make them a subject worthy of continued scientific exploration.