‘EASIdig’ – A Digital Tool to Document Disease Activity in Atopic Dermatitis

Tremp, Mathias; Knafla, Imke; Burg, Günter; Wüthrich, B; Schmid‐Grendelmeier, Peter

doi:10.1159/000330333

Cited by 19 publications

(11 citation statements)

References 41 publications

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“…The HOME initiative will continuously review new and emerging outcome measures as they are published, such as the EASIdig, a recently published digital tool for the digital assessment of severity and extent of atopic eczema, that has been shown to correlate with SCORAD and EASI scores .…”

Section: Discussionmentioning

confidence: 99%

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting

Schmitt

Spuls

Boers

et al. 2012

Allergy

182

203

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The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from 10 countries, representing different stakeholders (patients, clinicians, methodologists, pharmaceutical industry) to determine core outcome domains for atopic eczema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics for atopic eczema outcomes research. Delegates were given evidence-based information, followed by structured group discussion and anonymous consensus voting. Consensus was achieved to include clinical signs, symptoms, long-term control of flares and quality of life into the core set of outcome domains for atopic eczema trials. The HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic eczema trials. Measures of these core outcome domains need to be valid, sensitive to change and feasible. Prioritized topics of the HOME initiative are the identification/development of the most appropriate instruments for the four core outcome domains. HOME is open to anyone with an interest in atopic eczema outcomes research.

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Section: Discussionmentioning

confidence: 99%

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting

Schmitt

Spuls

Boers

et al. 2012

Allergy

182

203

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“…In ophthalmology, digital photography and analysis are used for diagnosis of the anterior eye segment [37], for vessel detection in corneal transplants [38], for analyzing the corneal involvement of pterygium conjunctivae [39,40], for noninvasive calculation of hemoglobin in the wide field of emergency medicine [41], for examining rotational stability of intraocular lenses [42], in diagnosis of dry eye [43] and in the observation of side effects of antiglaucomatous treatment [44]. In dermatology they are implemented for measuring erythema and edema of the skin prick test [45,46,47] or intradermal skin tests [48], for analyzing repigmentation during treatment of vitiligo [49], for quantification of skin lesions [50], and in diagnosis and treatment of atopic dermatitis [51,52]. Otorhinolaryngology makes use of this technique during endoscopic transsphenoidal pituitary surgery [53] and for video-laryngoscopic-assisted surgery [54], while it is used for analysis of body posture in patients with asthma [55,56] in pediatrics.…”

Section: Introductionmentioning

confidence: 99%

Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis

Dogan

Astvatsatourov

Deserno

et al. 2013

Int Arch Allergy Immunol

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Background: Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no international guidelines defining the CPT. No approved evaluation method exists for interpreting CPT results. This paper aims to establish the digital analysis of macroimages as an objective, validated and standardized method for interpreting CPT results. Methods: In a clinical immunotherapy trial with 155 patients, treatment progress was documented based on the CPT. Local investigators used a symptom score to grade tearing, reddening and the patients' subjective perception of symptoms (mucosal irritation). A central observer rated conjunctival hyperemia via digital photography. Digital image analysis software was utilized to determine conjunctival hyperemia. Results: Spearman's correlation between the local investigators' and the central observer's ratings was r = 0.729 (p < 0.001); the percentage of total agreement was 48% (based on 739 photos). Digital image analysis (based on 48 photos) had a high percentage of total agreement with the central observer's ratings (69%) but a low percentage of total agreement with the investigators' ratings (38%). The corresponding correlations were r = 0.264 and 0.064, respectively. Conclusion: Photography-based rating by a central observer may represent a valuable supplement to the local investigator's assessment for making an objective evaluation of CPT results. Digital image analysis possesses the potential of being an objective evaluation method compared to the wide-spread subjective evaluation by the investigators.

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“…18 The HOME initiative will continuously review new and emerging outcome measures as they are published, such as the EASIdig (EASI score established from the digital images), a recently published digital tool for the digital assessment of severity and extent of AE, that has been shown to correlate with SCORAD index and EASI scores. 311 The panel highlighted the need to design and/or validate adequate instruments that meet the OMERACT filter to measure the four core outcome domains symptoms, clinical signs, long-term control and QoL.…”

Section: Discussionmentioning

confidence: 99%

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

Kim

Batchelor

Bath‐Hextall

et al. 2016

Programme Grants Appl Res

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Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10177. The contractual start date was in September 2008. The final report began editorial review in April 2014 and was accepted for publication in April 2016. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, CCF, NETSCC, PGfAR or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, ...

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‘EASIdig’ – A Digital Tool to Document Disease Activity in Atopic Dermatitis

Cited by 19 publications

References 41 publications

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting

Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting

Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

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