Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

Thapa, Raj Kumar; Byeon, Jeong Hoon; Ku, Sae Kwang; Yong, Chul Soon; Kim, Jong Oh

doi:10.1038/am.2017.141

Cited by 27 publications

(6 citation statements)

References 46 publications

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“…Upon exposure to near-infrared (NIR) irradiation, the photosensitizer converts the absorbed light energy into thermal energy and generates singlet oxygen ( 1 O 2 ) from tissue oxygen, ultimately resulting in local hyperthermia and tumor damage (necrosis and/or apoptosis) 2 . NIR-triggered tumor ablation has particular advantages over conventional therapeutic methods, including high and precise local temperature, preservation of surrounding tissues, short recovery time, destruction of tumor vessels, induction of acute inflammatory responses, and deprivation of oxygen and nutrients in tumor areas 3 , 4 . However, their limited accumulation in tumor, water-insoluble characteristics, and instability restrict the application of photosensitizers.…”

Section: Introductionmentioning

confidence: 99%

Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy

Jiang

Thapa

et al. 2018

Theranostics

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The efficacy of combined near-infrared (NIR) and immune therapies for inhibiting tumor growth and recurrence has gained increasing research attention. Regulatory T cells in the tumor microenvironment constitute a major obstacle in achieving robust CD8+ T cell antitumor immunotherapy. In the present study, we designed a photoimmunotherapy-based strategy involving a combination of photothermal and photodynamic therapies, followed by Treg cell suppression, for eliciting an immune response with IR-780- and imatinib-loaded layer-by-layer hybrid nanoparticles.Methods: The layer-by-layer hybrid nanoparticles were prepared through electrostatic interactions. Their photothermal effect, photodynamic effect as well as their effect on inhibiting Treg cells' suppressive function were investigated in vitro and in vivo. Their antitumor effect was evaluated using B16/BL6 and MC-38 tumor-bearing mice.Results: The layer-by-layer hybrid nanoparticles, which were pH-sensitive, enabled the release of IR-780 dye for NIR-induced photothermal and photodynamic effects, and the release of imatinib-loaded glucocorticoid-induced TNF receptor family-related protein/poly(lactic-co-glycolic acid) (GITR-PLGA) nanoparticles to initiate antitumor immunotherapy. The photothermal and photodynamic effects caused by IR-780 under NIR exposure resulted in direct tumor apoptosis/necrosis and the production of tumor-associated antigen, promoted dendritic cell maturation, and enhanced the presentation of tumor-associated antigen to T cells, while the imatinib-loaded GITR-PLGA cores reduced the suppressive function of Treg cells, and consequently activated effective CD8+ T cells towards tumors.Conclusion: With the significant photothermal, photodynamic and immunotherapies, the system successfully eradicated tumor growth, diminished tumor recurrence, and improved survival in vivo. The proposed nanoparticles provide a novel and versatile approach to boost antitumor photoimmunotherapy.

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Section: Introductionmentioning

confidence: 99%

Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy

Jiang

Thapa

et al. 2018

Theranostics

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“…Thus, to adequately deliver GO nanoflakes into the tumor area, the nanoflakes were coated with both PEG and chitosan in the liquid phase and were then administered to treat various cancer types. A biodistribution study demonstrated that the delivery and delivery speed of chitosan-coated nanoparticles into the tumor area were significantly increased compared with the non-coated nanoparticles, therefore leading to an enhanced targeted antitumor effect (Thapa et al 2017 ). The use of biodegradable and disintegrable inorganic nanosystems for cancer treatment has become dramatically more frequent due to the nanopaticles’ less toxic effects on vital organs.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Fabrication of aerosol-based nanoparticles and their applications in biomedical fields

Gautam

Kim

Yong

2021

J. Pharm. Investig.

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Background Traditionally, nanoparticles for biomedical applications have been produced via the classical wet chemistry method, with size control remaining a major problem in drug delivery. In recent years, advances in aerosol-based technologies have led to the development of methods that enable the production of nanosized particles and have opened up new opportunities in the field of nano-drug delivery and biomedicine. Aerosol-based technologies have been constantly used to synthesize multifunctional nanoparticles with different properties, which extends their possible biological and medicinal applications. Moreover, aerosol technologies are often more beneficial than other existing approaches because of the major disadvantages of these other techniques. Area covered This review provides a brief discussion of the existing aerosol-based nanotechnologies and applications of nanoparticles in a variety of diseases. Various types of nanoparticles, such as graphene oxide, Prussian blue, black phosphorous, gold, copper, silver, tellurium, iron oxide, titania, magnesium oxide, and zinc oxide nanoparticles, prepared using aerosol technologies are discussed in this review. The different tactics used for surface modifications are also outlined. The biomedical applications of nanoparticles in chemotherapy, bacterial/fungal/viral treatment, disease diagnosis, and biological assays are also presented in this review. Expert opinion Aerosol-based technologies can be used to design nanoparticles with the desired functionality. This significantly benefits the nanomedicine field, particularly as product parameters are becoming more encompassing and exacting. One of the biggest issues with conventional methods is their scale-up/scale-down and clinical translation. Aerosol-based nanoparticle synthesis helps enhance control over the product properties and facilitate their use for clinical applications.

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“…此外, 有机小分子化合物还可以通过非共价键作用对 GO 进行表面修饰, 如静电力、范德华力、氢键和π-π堆积作用等 [15] . 通过π-π堆积作用, 可以将具有芳香环结构的抗癌药物修饰到 GO 表面(图 3), 如阿霉素(DOX) [64,65] 和喜树碱(CPT) [66,67] , 进而将药物递送到肿瘤细胞与组织 [68] . 例如, 利用 π-π 堆积和疏水作用将 DOX 装载到转铁蛋白(Tf)与 PEG 修饰的 GO (Tf-PEG-GO)表面, 装载效率可达 115.4%, 对大鼠 C6 神经胶质瘤具有良好的靶向治疗效果 [69] .…”

Section: N-(3-二甲氨丙基)-n'-乙基碳二亚胺(edc)/n-羟基丁二unclassified

Surface Chemical Modifications of Graphene Oxide and Interaction Mechanisms at the Nano-Bio Interface

Ma¹,

Xu²,

Liu³

2020

Acta Chim. Sinica

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Due to the unique physicochemical properties, graphene oxide has been widely applied in material chemistry, biomedical science and life science. However, here is still a great challenge to maximize the advantages of graphene oxide and overcome the deleterious effects caused by its inherent properties. For a better understanding of current status in this research field, recent progress in surface chemical modifications of graphene oxide and interaction mechanisms at the nano-bio interface has been comprehensively reviewed. First, the physicochemical properties of graphene oxide and the representative strategies of surface chemical modifications will be briefly introduced, including oxidation and reduction, carboxylation, amination, small organic molecule modification, polymer modification, peptide/protein modification, nucleic acid modification and nanoparticle modification, as well as their potential roles in mediating the graphene oxide-resulted biological effects. Following, we will present the primary interaction mechanisms of pristine and surface-modified graphene oxide at the nano-bio interface, including the formation of protein corona, cell membrane damage, membrane receptor interaction and oxidative stress. Finally, the knowledge gaps and future challenges in this research field will be detailedly discussed. Keywords graphene oxide; surface chemical modification; nano-bio interface; interaction mechanism; biological effect 1 引言 2004 年, Geim 等 [1] 首次通过机械剥离法制得单层石墨烯. 石墨烯(graphene)是一种二维纳米材料, 具有类似蜂巢的六元环平面网状结构, 厚度仅为 0.3354 nm [1] . 在石墨烯的纳米片层结构中, 碳原子发生了 sp 2 杂化, 每个碳原子通过键长为 142 nm 的 σ 键与其它三个碳原子连接, 并在与片层垂直的方向形成离域大 π 键 [2,3] . 这些结构特征赋予了石墨烯优异的机械强度、化学稳定性、高比表面积、导电和导热性能 [4][5][6][7] . 因此, 石墨烯在能源、材料、健康、环境等方面都展现了广阔的应用前景.石墨烯拥有多种衍生物, 包括氧化石墨烯(graphene oxide, GO)、还原氧化石墨烯(reduced graphene oxide, rGO)、氟化石墨烯(fluorographene)等.

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Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

Cited by 27 publications

References 46 publications

Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy

Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy

Fabrication of aerosol-based nanoparticles and their applications in biomedical fields

Surface Chemical Modifications of Graphene Oxide and Interaction Mechanisms at the Nano-Bio Interface

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