Easy solventless synthesis of new mono and bis amino-5H-chromeno [3,4-c] pyridin-5-one derivatives

Kibou, Zahira; Villemin, Didier; Lohier, Jean‐François; Cheikh, Nawel; Bar, Nathalie; Choukchou‐Braham, Noureddine

doi:10.1016/j.tet.2016.01.063

Cited by 17 publications

(7 citation statements)

References 23 publications

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“…Following to our interest on the synthesis of heterocyclic compounds [30][31][32][33][34][35], we describe here a synthesis of a new class of bis-2-pyridone compounds (Figure 2) with fluorescent properties, there is no publication about fluorescent properties of bis-pyridones.…”

Section: Figure 1 Some Natural Products Bearing a Pyridone Moietymentioning

confidence: 99%

Novel bis-(3-cyano-2-pyridones) derivatives: synthesis and fluorescent properties

et al. 2021

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Novel substituted bis-(3-cyano-2-pyridone) derivatives were prepared via a powerful method using enaminonitriles push-pull dienes as key building blocks. The synthesis was performed in three-steps from easily accessible starting materials in good yields. All target products were structurally elucidated by spectroscopic data. The reaction mechanism for formation of bis (3cyano-2-pyridone) derivatives was proposed. The structures of enaminonitriles 3a and bispyridones 4c were confirmed by single-crystal X-ray diffraction. The florescent study of some bis (3-cyano-2-pyridones) derivatives was reported.

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Section: Figure 1 Some Natural Products Bearing a Pyridone Moietymentioning

confidence: 99%

Novel bis-(3-cyano-2-pyridones) derivatives: synthesis and fluorescent properties

et al. 2021

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“…Kibou et al . established an efficient, simple, mild, solvent free, environmentally friendly procedure for the synthesis of novel amino‐5 H‐ chromeno [3,4‐ c ] pyridin‐5‐ones 44 starting from a cyano enamino coumarin 43 as a key precursor and several primary amines or diamines (Scheme ).…”

Section: Synthesis Of Pyridocoumarinsmentioning

confidence: 99%

A Concise Review on Pyridocoumarin/Azacoumarin Derivatives: Synthesis and Biological Activity

Patra¹

2019

ChemistrySelect

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Coumarins are important due to their versatile bio‐activity. Synthesised pyridocoumarin derivatives show remarkable biological activities including antifungal, antibacterial, antitumor, antiHIV, and antimicrobial activity. The present review aims to review a vast body of literature on different synthetic methodology mainly aza‐Diels Alder reaction, metal catalyzed cyclization and multicomponent reaction and bioactivity of pyridocoumarin derivatives as published during the period from 1997 up to 2017. The synthesised compounds have been reported in literature either by construction of pyridine, pyran or of both ring starting from suitable precursors.

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“…More recently, Villemin and co-workers have developed an efficient and practical procedure for the preparation of chromeno [3,4-c]pyridines from cyanoenaminocoumarin and primary amines. 14…”

Section: Pyridine Structuresmentioning

confidence: 99%

Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

Fan

Zheng

Yang

et al. 2018

Synlett

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This work discloses a novel and eﬃcient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows the advantages of mild reaction conditions, easy workup, nonchromatographic puriﬁcation technique, good functional group tolerance, and moderate to good yields.

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Easy solventless synthesis of new mono and bis amino-5H-chromeno [3,4-c] pyridin-5-one derivatives

Cited by 17 publications

References 23 publications

Novel bis-(3-cyano-2-pyridones) derivatives: synthesis and fluorescent properties

Novel bis-(3-cyano-2-pyridones) derivatives: synthesis and fluorescent properties

A Concise Review on Pyridocoumarin/Azacoumarin Derivatives: Synthesis and Biological Activity

Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

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