EBV‐positive Burkitt's lymphoma from algeria, with a three‐way rearrangement involving chromosomes 2, 8 and 9

Philip, Thierry; Lenoir, Gilbert; Fraisse, J; Philip, I; Bertoglio, Jacques; Ladjaj, S.; Bertrand, S.; Brunat‐Mentigny, M.

doi:10.1002/ijc.2910280404

Cited by 21 publications

(3 citation statements)

References 24 publications

(28 reference statements)

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“…With probe 8q305, we screened a genomic library, prepared from placental DNA in phage XEMBL3, and isolated a set of overlapping clones spanning a total of 30 kbp. Figure 3A shows a restriction map of the cloned chromosome 8 Cell line BL21 (27) harbors a complex translocation, t(2;8;9), in which, as judged by the banding pattern, a segment of chromosome 9 is inserted between the long arm of chromosome 8 and the translocated short arm of chromosome 2 on the 8q+ marker chromosome. To cloned size-fractionated HindIII fragments of BL21 DNA in phage XL47 and isolated clone 21.1 ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

Henglein¹,

Synovzik²,

Groitl³

et al. 1989

Mol. Cell. Biol.

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The variant translocations t(2;8) in Burkitt's lymphoma cells join band q24 of chromosome 8, distal from c-myc, to the Igkappa locus, with considerable variation in the location of the breakpoints on chromosome 8. We report the cloning and molecular characterization of a chromosome 8 region, distal from the c-myc locus, which encompasses the breakpoints of the Burkitt's lymphoma cell lines BL64, BL21, and LY91 within 11 kilobase pairs, termed provisionally bvr-1 (Burkitt's variants' rearranging region 1). Using probes from the c-myc, the bvr-1, and the human pvt-1 loci obtained by chromosome walking coupled with pulsed-field gel electrophoresis, we have constructed a physical map of the region 3' of c-myc. We map bvr-1 and pvt-1 about 140 and 260 kilobase pairs, respectively, distal from c-myc.

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Section: Resultsmentioning

confidence: 99%

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

Henglein¹,

Synovzik²,

Groitl³

et al. 1989

Mol. Cell. Biol.

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“…of patients/No. screened Clinical phenotype Primary mutation/associated with other abnormalities Consanguinity Reference Burkitt’s lymphoma Algeria Rec ** t(2;8;9) De novo 9y/M 1/22 Jaw and abdominal tumors, facial asymmetry, enlarged lymph nodes, and abdominal masses A three-way recombination with translocation and insertion - Philip et al 1981 ) AML Jordan Rec * t(15;16;17;19) - 58y/F 1/1 Acute promyelocytic leukemia (AML-M3) Primary complex translocation - Kamal et al 1996a ) AML Lebanon - ** t(8;12;21)(q22;p12 approximately p13;q22) - 32y/M 1/1 AML (FAB- M2) Associated with chromosomal abnormalities (loss of Y ch. and trisomy 8q22) - Farra et al 2004 ) CML Kuwait Rec ** t(9;22;12)(q34;q11;p11) - 26y/M 1/1 Similar to CML clinical features Primary - Zámecˇníkova et al 2012 ) CML - * t(9;22;7;1)(q34;q11;q22;p13) - 64y/M ...…”

Section: Resultsmentioning

confidence: 99%

The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases

2022

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Chromosomal translocations (CTs) are the most common type of structural chromosomal abnormalities in humans. CTs have been reported in several studies in the Arab world, but the frequency and spectrum of these translocations are not well characterized. The aim of this study is to conduct a systematic review to estimate the frequency and spectrum of CTs in the 22 Arab countries. Four literature databases were searched: PubMed, Science Direct, Scopus, and Web of Science, from the time of inception until July 2021. A combination of broad search terms was used to collect all possible CTs reported in the Arab world. In addition to the literature databases, all captured CTs were searched in three chromosomal rearrangement databases (Mitelman Database, CytoD 1.0 Database, and the Atlas of Genetics and Cytogenetics in Oncology and Hematology), along with PubMed and Google Scholar, to check whether the CTs are unique to the Arabs or shared between Arabs and non-Arabs. A total of 9,053 titles and abstracts were screened, of which 168 studies met our inclusion criteria, and 378 CTs were identified in 15 Arab countries, of which 57 CTs were unique to Arab patients. Approximately 89% of the identified CTs involved autosomal chromosomes. Three CTs, t(9;22), t(13;14), and t(14;18), showed the highest frequency, which were associated with hematological malignancies, recurrent pregnancy loss, and follicular lymphoma, respectively. Complex CTs were commonly reported among Arabs, with a total of 44 CTs, of which 12 were unique to Arabs. This is the first study to focus on the spectrum of CTs in the Arab world and compressively map the ethnic-specific CTs relevant to cancer. It seems that there is a distinctive genotype of Arabs with CTs, of which some manifested with unique clinical phenotypes. Although ethnic-specific CTs are highly relevant to disease mechanism, they are understudied and need to be thoroughly addressed.

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“…It must be emphasized also that the present study gives further examples of typical variant translocations in BL (Mark-Vendel et al, 1983), and of a complex three-way rearrangement (Philip et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Abdominal Burkitt-type lymphomas in Algeria

Ladjadj¹,

Philip²,

Lenoir³

et al. 1984

Br J Cancer

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In a previous retrospective analysis from the principal paediatric centres of Algeria, Burkitt-type lymphomas (BL) were shown to account for around 46.5% of the total childhood non-Hodgkin's malignant lymphomas in that country. In the present study, a series of 49 abdominal BL from the Paediatric Clinic of Surgery, Mustapha Hospital, Algiers, has been studied. The age distribution shows a peak between 4 and 5 years of age, and the sex ratio is (M:F) 2.26:1. The disease is characterized by a rapid evolution in the absence of therapy. The major problem is an explosive form of the disease, which at present seems difficult to control in this country. Fifteen of the 49 patients (30.6%) died before completion of the first course of chemotherapy; however, complete remission (CR) was obtained for 30 patients (61%). Overall survival was 42.85% (21/49), whereas survival of patients who reached CR is 70% (21/30). When CR was obtained, deaths were related to cerebrospinal fluid involvement, local recurrence, secondary bone marrow involvement or therapeutic accidents. All patients alive with no evidence of disease (NED) 8-months after CR can be considered definitively cured. Epstein-Barr virus (EBV) serology performed on 31 BL patients and on a control group of 25 children with other malignant tumours showed that most Algerian BL have elevated EBV titres. A search for viral markers within malignant cells in 17 patients indicated that 88% (15/17) of the BL cases were EBV-associated. Analysis of the immunological and cytogenetic data showed that, as in the rest of the world, these BL cases involve proliferation of B-cell-type lymphocytes, with characteristic cytogenetic translocations involving chromosome 8. This report represents the most detailed description so far of BL from an area in non-equatorial Africa and the first report of a large series from North Africa.

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EBV‐positive Burkitt's lymphoma from algeria, with a three‐way rearrangement involving chromosomes 2, 8 and 9

Cited by 21 publications

References 24 publications

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases

Abdominal Burkitt-type lymphomas in Algeria

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