Eccrine Angiomatous Hamartoma , with Verrocous Hemangioma-like Features : A Case Report

Eccrine angiokeratomatous hamartoma combined with solitary angiokeratoma or verrucous venous malformation: Report of two cases and comprehensive review of the literature

“…All the lesions were present since birth or appeared during the childhood, and presented as a red to violaceous, keratotic, nodule, or plaque that gradually grew in size . EAKH can be painful and hyper‐hidrotic, rarely ulcerating after trauma . Curiously, our cases and that reported by Cheong et al are the only ones showing a sudden growth .…”

“…Indeed, staining for WT1 may be a guide in differentiate proliferative vascular lesions, typically positive for WT1, from vascular malformation usually negative in both children and adults . Since the description by Kanitakis et al, only eight other cases have been clinically and histopathologically documented (Table ) . In our review of the literature, no clinical and epidemiological differences were noted between lesions showing a superficial vascular component of SAK rather than VVM.…”

“…This finding could be an additional demonstration that these lesions represent a unique entity, without the need to distinguish the superficial vascular component. Interestingly, in all the described cases the lesions were located on the lower limb, and only two patients showed multiple lesions . Our second case is the only one reported outside the lower extremities, being located on the trunk.…”

“…It has unique histopathological features, deriving from the combination of two different vascular hamartomatous lesions: solitary angiokeratoma (SAK) and eccrine angiomatous hamartoma (EAH). However, other authors described analogous vascular malformations with a combination of verrucous hemangioma (VH) or verrucous venous malformation (VVM) and EAH . We present two cases of vascular hamartoma showing a histopathological combination of EAH with SAK/VVM or VH.…”

“…Our second case is the only one reported outside the lower extremities, being located on the trunk. All the lesions were present since birth or appeared during the childhood, and presented as a red to violaceous, keratotic, nodule, or plaque that gradually grew in size . EAKH can be painful and hyper‐hidrotic, rarely ulcerating after trauma .…”