Eccrine Porocarcinoma: A Multicenter Retrospective Study with Review of the Literatures Reported in Korea

Abstract

Background: Eccrine porocarcinoma (EPC) is a rare malignant cutaneous adnexal tumor. Other than several scattered case reports, no comprehensive review on EPC has been conducted in Korea. Objective: To clinicopathologically review all EPC cases from our institutions as well as those reported in Korea. Methods: Medical records and histopathological slides of EPC cases in the skin biopsy registries of our institutions were retrospectively reviewed. Additionally, EPC cases reported in Korea before June 2019 were retrieved by searching the PubMed, KoMCI, KoreaMed, and KMbase databases. Results: Nine EPC cases from our institutions were included in the study. In addition, 27 reports of 28 patients with EPC were reported in Korea. A total of 37 patients with EPC were identified, consisting of 19 males (male:female ratio, 1.06:1; mean age at diagnosis, 65.6 years). The most common site of primary tumor was the head and neck (29.7%). Wide excision was the most common (78.4%) treatment method. Initial metastasis work-up imaging studies were performed in 18 patients (48.6%), and metastasis was confirmed in eight patients (21.6%). Conclusion: EPC is a rare cutaneous carcinoma in Korea. EPC usually affects elderly patients, with no sexual predilection. Due to possible metastasis, careful diagnosis and appropriate metastasis workups are warranted in EPC. (Ann Dermatol 32(3) 223∼229, 2020

Diagnosis and Management of Porocarcinoma

“…The incidence increases with age, and the disease is reported to affect mostly those in their 70s and 80s. Some studies have reported mean ages at diagnosis that vary from 67 to 76 years, but these ages converge at around 70 years [ 6 , 7 , 11 , 12 ]. A few cases of eccrine porocarcinoma in young patients have been reported.…”

Porocarcinoma of the left arm: A report of a rare skin cancer case and literature review

“…37 Metastatic cervical lymph nodes successfully treated with cyberknife radiosurgery have also been mentioned. 38 In conclusion, the best chance for cure is early diagnosis and surgery because neither chemotherapy nor radiotherapy has shown some clinical benefit in metastatic PC.…”

“… 37 Metastatic cervical lymph nodes successfully treated with cyberknife radiosurgery have also been mentioned. 38 …”

Porocarcinoma of the Left Arm: A Report of a Rare Skin Cancer Case and Literature Review

“…Radiosensitivity of PC is suggested by some case reports. Adjuvant radiotherapy is not yet standard of care, but it would be recommended in high-risk situations, such as cases with positive surgical margins, tumors larger than 5 cm, lymphovascular involvement, and tumors with moderate to poorly differentiated grading [20]. Metastatic cervical lymph nodes successfully treated with cyberknife radiosurgery have also been mentioned.…”