Ecdysteroids from the flowers of Aerva javanica

Saleem, Muhammad; Musaddiq, Sara; Riaz, Naheed; Zubair, Momina; Ashraf, Muhammad; Nasar, Rumana; Jabbar, Abdul

doi:10.1016/j.steroids.2013.07.012

Cited by 15 publications

(7 citation statements)

References 11 publications

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“…6)-glactoside], aervanone, isorhamnetin-3-O-b-[4 000 -p-coumaroyl-a-rhamnosyl(1 ! 6)galactoside], ecdysteroids, ascorbic acid, b-sitosterol, gallic acid, alkaloids, and terpenoids (Garg et al 1980;Saleh et al 1990;Mussadiq et al 2013;Saleem et al 2013). This evidence suggests that anti-inflammatory effect of APAE may be attributed to presence of rutin and other phenolic compounds and further strengthens the present findings.…”

Section: Discussionsupporting

confidence: 88%

Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves

Pandey

Kaushik²,

Wanjari

et al. 2017

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 88%

Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves

Pandey

Kaushik²,

Wanjari

et al. 2017

Pharmaceutical Biology

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“…Very recently, A. Javanica -derived aervecdysteroid A–D ( 1 – 4 ) and acylated flavone glycosides have been shown to inhibit enzymatic activities of lipoxygenase and butyrylcholinesterase ( 53 ). In mammals, lipoxygenases catalyze the formation of hydroperoxides as the first step in the biosynthesis of several inflammatory mediators ( 54 ). Butyrylcholinesterase, also known as serum or plasma cholinesterase, is synthesized in the liver that hydrolyzes many different choline-based esters.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of ethanolic extract ofAerva javanicaaerial parts in the amelioration of CCl₄-induced hepatotoxicity and oxidative damage in rats

Arbab

Parvez

Al‐Dosari

et al. 2016

Food & Nutrition Research

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BackgroundLiver diseases, the fifth most common cause of global death, can be metabolic, toxin-induced, or infective. Though approximately 35 Saudi medicinal plants are traditionally used to treat liver disorders, the hepatoprotective potential of Aerva javanica has not been explored.ObjectiveTo investigate the antioxidative and hepatoprotective effect of Aerva javanica.DesignTotal ethanol extract of A. javanica aerial parts was prepared and tested on DCFH-toxicated HepG2 cells ex vivo, and in CCl4-injured Wistar rats in vivo. MTT assay was used to determine cell viability and the serum biochemical markers of liver injury as well as histopathology was performed. In vitro 1,1-diphenyl-2-picrylhydrazyl and β-carotene free-radical scavenging assay and phytochemical screening of the extract were done. Furthermore, A. javanica total extract was standardized and validated by high-performance thin layer chromatographic method.ResultsMTT assay showed that, while DCFH-injured cells were recovered to ~56.7% by 100 µg/ml of the extract, a 200 µg/ml dose resulted in hepatocytes recovery by ~90.2%. Oral administration of the extract (100 and 200 mg/kg.bw/day) significantly normalized the serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, gamma-glutamyl transferase, alkaline phosphatase, bilirubin, cholesterol, high-density lipoprotein, low-density lipoprotein, very-low-density lipoprotein, triglyceride, and malondialdehyde levels, including tissue nonprotein sulfhydryl and total protein in CCl4-injured rats. In addition, the histopathology of dissected liver also revealed that A. javanica cured the tissue lesion compared to silymarin treatment. In vitro assays revealed strong free-radical scavenging ability of the extract and presence of alkaloids, flavonoids, tannins, sterols, and saponins where rutin, a well-known antioxidant flavonoid, was identified.ConclusionsOur findings demonstrate the potential of A. javanica in the attenuation of ex vivo and in vivo hepatotoxicity and oxidative damage. This further suggests its therapeutic value in various liver diseases. However, isolations of the active principles, their mechanisms of action, and other therapeutic contributions remain to be addressed.

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“…Flowers methanolic extract showed clear activity of the following enzymes inhibition: acetylcholinesterase (AChE), butyrylcholinesterase (BChE)and lipoxygenase (LOX). 200…”

Section: Enzyme Inhibitionmentioning

confidence: 99%

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Azab¹

2020

ECB

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Ecdysteroids from the flowers of Aerva javanica

Cited by 15 publications

References 11 publications

Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves

Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves

Therapeutic efficacy of ethanolic extract ofAerva javanicaaerial parts in the amelioration of CCl₄-induced hepatotoxicity and oxidative damage in rats

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

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Ecdysteroids from the flowers of Aerva javanica

Cited by 15 publications

References 11 publications

Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves

Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves

Therapeutic efficacy of ethanolic extract ofAerva javanicaaerial parts in the amelioration of CCl4-induced hepatotoxicity and oxidative damage in rats

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

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Therapeutic efficacy of ethanolic extract ofAerva javanicaaerial parts in the amelioration of CCl₄-induced hepatotoxicity and oxidative damage in rats