Ecdysteroids from Vitex pinnata

Quantitative determination of 20-hydroxyecdysone in methanolic extract of twigs from Vitex polygama Cham.

“…This procedure was repeated with isolated 20E to obtain a completely pure compound. 20E and the two other obtained ecdysteroids were characterized by 1D and 2D NMR, mass and microanalysis data, whose were in agreement with literature [16][17][18].…”

Absolute Configuration and Docking Study of Canescensterone, a Potent Phytoecdysteroid, with Non‐Lepidopteran Ecdysteroid Receptor Selectivity

“…[24] Upon hydrolysis with guanidine, canescensterone can be transformed into pinnatasterone, [12] which indicates the same stereochemistry of the steroid ring system and the side-chain at C-17. In the Musca domestica bioassay, canescensterone showed higher activity than pinnatasterone, which indicates the importance of the substituent.…”

“…Interestingly, a literature search revealed that the side-chain configuration for a number of ecdysteroids, especially with two methylene groups in the side-chain, has only been assigned tentatively. [24,27] In the past, differences in chemical shifts were used to identify the configuration at C-24. [28] However, some ecdysteroids show negligible differences in their 13 C chemical shifts even though they represent epimers (e.g., 20,26-dihydroxyecdysone).…”

Ecdysteroids from Vitex Species: Distribution and Compilation of Their 13C‐NMR Spectral Data

“…-An extensive literature search was undertaken to identify studies on ecdysteroids in works such as periodicals, data banks such as NAPRALERT (Natural Products Alert) and that at the University of Illinois, Chicago, Chemical (24) [ 2 ] 24-Epimakisterone A (8) [ 8 ] Calonysterone (9) [8] [10] Turkesterone (2) [ 8 ] [ 9 ] 24-Epiabutasterone (11) [ 8 ] Shidasterone (5) [ 8 ] 20,26-Dihydroxyecdysone (19) [11] (24R )-11a,20,24-Trihydroxyecdysone (17) [12] 11a,20,26-Trihydroxyecdysone (15) [12] Canescensterone (4) [ (13) [24] Calonysterone (9) [24] Pterosterone (22) [24] 24-Epimakisterone A (8) [24] 20-Hydroxyecdysone (1) [24] Polypodine B (23) [24] Ajugasterone C (6) [24] Pinnatasterone (3)…”