Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation

Li, Xiuhui; Gou, Chunyan; Yang, Huasheng; Qiu, Jinpeng; Gu, Tao; Wen, Tao

doi:10.3109/00365521.2014.913190

Cited by 45 publications

(34 citation statements)

References 28 publications

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“…Animal products, such as Chinese traditional fermented yogurt and an extract of abalone ( Haliotis discus hannai Ino), can protect the liver against LPS toxicity with similar mechanisms as mentioned above (Peng & Jiang, ; Debnath et al., ). In addition, in mice or rats treated with LPS plus D‐galactosamine (D‐GaIN), the protective mechanisms of the natural products such as nobiletin from Citrus fruits and echinacoside from Cistanche salsa mainly lie in the activation of Nrf2 and the inhibition of NF‐κB‐mediated cytokine production to ameliorate inflammation and apoptosis (He et al., ; Li et al., ). Also, soy genistein was demonstrated to prevent D‐GalN‐driven chronic liver damage and liver fibrosis through the inhibition of TGF‐β/Smad signaling pathway (Ganai & Husain, ).…”

Section: Protective Effects Of Natural Products On Pollutant‐induced mentioning

confidence: 99%

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

Meng

et al. 2018

Comp Rev Food Sci Food Safe

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Chemicals (such as alcohol, drugs, and pollutants) may cause liver injuries, which could consequently develop into fatty liver, hepatitis, fibrosis, cirrhosis, and liver failure, or even cancers. Liver injuries have been a serious public health problem worldwide. Numerous natural products and their bioactive components have shown protective action for liver injuries, such as blueberry, cactus fruits, Pueraria lobate, betaine, and silymarin. The underlying mechanisms mainly include antioxidation, anti-inflammation, anti-apoptosis, anti-necrosis, repairing damaged DNA, regulating the metabolism of lipids, and modulating primary bile acid biosynthesis. This review summarizes the natural products and bioactive compounds with protective effects on liver injuries caused by chemicals, and special attention is paid to the mechanisms of action. This updated information can be helpful to prevent and treat liver-related diseases, especially chemical-induced liver injuries.

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Section: Protective Effects Of Natural Products On Pollutant‐induced mentioning

confidence: 99%

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

Meng

et al. 2018

Comp Rev Food Sci Food Safe

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“…Herba (H.) Cistanche, a Chinese herbal medicine commonly used in mainland China for nourishing the kidneys and replenishing essence and blood, has been used to treat memory loss and senile constipation (17). Phenylethanoid glycoside (PhG), one of the major constituents in H. Cistanche, improves the impairment of neuronal apoptosis caused by Aβ 25-35 via its anti-oxidant effects (18,19).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of phenylethanoid glycosides in an in vitro model of Alzheimer's disease

Yang

Yao

et al. 2017

Experimental and Therapeutic Medicine

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The present study aimed to investigate the neuroprotective effects of phenylethanol glycosides (PhGs) on HO- and β-amyloid peptide (Aβ)-induced injury of PC12 cells as an model of Alzheimer's disease (AD). The optimal induction conditions were established through screening of various incubation times and concentrations. PC12 cells were treated with 0.5 µM Aβ and HO in the presence of PhGs for 24 h and the cell viability was then evaluated by an MTT assay; lactate dehydrogenase (LDH) release and malondialdehyde (MDA) content were also measured. The optimal conditions for establishing the AD model were the treatment of PC12 cells with 0.5 µM Aβ for 48 h, or with 25 µM HO dissolved in DMEM with PBS. PhGs at concentrations of 5, 25 and 50 µg/ml increased the viability and decreased LDH and MDA release by PC12 cells injured with Aβ or HO. In conclusion, the model of Aβ- and HO-induced PC12 cell injury was successfully established. PhGs were shown to have a significant neuroprotective effect against Aβ- or HO-induced cell injury.

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“…Echinacoside (ECH, Figure a), a phenylethanoid glycoside extracted from the medicinal Chinese herb Cistanche tubulosa , has various bioactivities such as antioxidation (Dalby‐Brown, Barsett, Landbo, Meyer, & Molgaard, ), anti‐inflammation (Jia et al, ), anticancer (Dong et al, ; Wang, Luo et al, ), hepatoprotection (Li et al, ), skin protection (Sgarbossa et al, ), and immune modulation (Li et al, ; Li, Song, Chu, & Zhang, ). Reports showed that ECH could protect against oxidative stress‐induced or neurotoxin‐induced neurotoxicity in primary rat cortical neurons, human neuroblastoma SH‐SY5Y cells, and pheochromocytoma (PC12) cells (Deng et al, ; Koo et al, ; Wang, Xuan, Tian, & Du, ; Zhu, Lu, & Li, ), and it could attenuate brain damage and improves cognitive function in animal models of Parkinson's disease and Alzhermer's disease (Geng, Tian, Tu, & Pu, ; Wei et al, ; Wu, Lin, & Su, ; Zhao, Gao, Li, & Cai, ).…”

Section: Introductionmentioning

confidence: 99%

The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK‐MDR1 cells as blood–brain barrier in vitro model

Zheng

Tang

et al. 2017

Phytotherapy Research

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Efficient transcytosis across the blood-brain-barrier is an important strategy for accessing drug targets within the central nervous system. Ligusticum chuanxiong Hort. was used as a messenger drug to increase the distribution of drugs in brain tissue in Traditional Chinese Medicine. The present study investigates the transport of echinacoside (ECH) through MDCK-MDR1 cell and the effects of ligustilide (LIG), senkyunolide A (SENA) and senkyunolide I (SENI) in chuanxiong on its transport. The results indicated that the absorption of ECH was relatively poor in MDCK-MDR1cells, and was concentration dependent and not saturable. The P-glycoprotein inhibitor verapamil could significantly increase the transport of ECH. It indicated that the transport mechanism might be passive diffusion as the dominating process with the active transportation mediated mechanism involved. The increased apparent permeability of ECH in A → B direction by ethylenediaminetetraacetic acid-Na suggested that ECH was absorbed via the paracellular route. The transport of ECH in A → B direction significantly increased when co-administrated with increasing concentrations of LIG, SENI and SENA. Western blot analysis and a decrease in transepithelial electrical resistance during the permeation experiment indicated that LIG, SENI and SENA had enhanced the transport of ECH in the BBB models attribute to down-regulate the expressions of claudin-5 and zonula occludens-1 expression.

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Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation

Abstract: Our results suggest that echinacoside can provide a pronounced protection against GalN/LPS-induced acute liver injury in mice, which may complement the available strategies for management of acute liver damage in clinical settings.

Cited by 45 publications

References 28 publications

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

Neuroprotective effects of phenylethanoid glycosides in an in vitro model of Alzheimer's disease

The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK‐MDR1 cells as blood–brain barrier in vitro model

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