Echo Doppler assessment of cardiac output and its relation to growth in normal infants

Sholler, Gary F.; Celermajer, John M.; Whight, Christopher M.; Bauman, Adrian

doi:10.1016/0002-9149(87)90363-8

Cited by 34 publications

(16 citation statements)

References 18 publications

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“…The following ECHO measurements were performed offline, using previously validated measurement techniques: A) Systolic function: 1. Cardiac output: LV output (LVO) was calculated using the aortic diameter and velocity time integral (VTI) measured by pulse wave Doppler at the aortic valve annulus from parasternal longaxis at the end of systole and apical 5-chamber views, respectively and standard formula [13]. Similarly, RVO was calculated using the pulmonary valve annulus diameter and VTI at the pulmonary valve annulus from parasternal short-axis and subcostal views, respectively.…”

Section: Methodsmentioning

confidence: 99%

Echocardiographic correlates of persistent pulmonary hypertension of the newborn

Aggarwal¹,

Natarajan²

2015

Early Human Development

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Section: Methodsmentioning

confidence: 99%

Echocardiographic correlates of persistent pulmonary hypertension of the newborn

Aggarwal¹,

Natarajan²

2015

Early Human Development

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“…Heart rate and cardiac output are greater in newborns than in older children and adults (Cayler et al, 1963;Sholler et al, 1987;Brown et al, 1997). This is in line with the general notion that animals with a smaller body size have a faster heart rate.…”

Section: Cardiac Outputmentioning

confidence: 56%

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

Liu

Xia

Guo

et al. 2012

J Expo Sci Environ Epidemiol

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The urinary metabolites of phthalates are well-accepted exposure biomarkers for adults and children older than 6 years but are not commonly used for infants owing to non-convenient sampling. In the light of this situation, a novel sampling method based on monitoring the urine expressed from the gel diaper was developed. The urine was expressed from the gel absorbent after mixing the absorbent with CaCl2 and then collected by a laboratory-made device; the urinary phthalate metabolites were extracted and cleaned using a solid-phase extraction (SPE) column and analyzed with high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry / mass spectrometry. To evaluate the method's feasibility, the following factors were investigated: the proportion of CaCl2 to gel absorbent, the urination volume variation and the target compounds' deposition bias in the diaper, the matrix blank of the different diaper brands, the storage stabilities and the recoveries of creatinine and phthalate metabolites in the expressed urine. Mono-methyl phthalate, mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate were involved. 70-80% of the urine can be expressed from the diaper, and the expressed spiking recoveries and the limit of detection of mono-phthalates ranged from 88.5-115% and 0.21-0.50 ng/ml. The method was applied to measure phthalate metabolites in 65 gel diaper samples from 15 infants, and the pilot data suggests the infants are commonly exposed to phthalates. In summary, the method for monitoring of infant exposure to phthalates is sound and validated, and the potential health effects from the vulnerable infants' exposure to phthalates should be concerned.39th Scientific Research Foundation for the Returned Overseas Chinese Scholars (SRF for ROCS); Hundred Talent Program of Chinese Academy of Sciences (CAS); CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08

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“…MPI is considered normal at 0.3 ± 0.03, that is, if the ratio of the sum of isovolumic contraction and relaxation times to the ventricular ejection time is a third. 18 The CDH population had a significantly impaired MPI with a mean value >0.5. On binary regression, risk Echocardiogram and congenital diaphragmatic hernia S Aggarwal et al of mortality in CDH was significantly associated with lower LV CI, elevated right and left sided MPI and PHT.…”

Section: Discussionmentioning

confidence: 96%

“…LV end-diastolic eccentricity index, a measure of the displacement of interventricular septum, was measured in the parasternal midpapillary short-axis view at both end-systole and end-diastole, using the method of Ryan et al as D1/D2, where D1 is the diameter of the LV parallel to the interventricular septum (anterior to inferior wall) and D2 is the diameter perpendicular to and bisecting the interventricular septum (septum to posterolateral wall; Figure 1b). 17 The left and RV output is calculated using method described by Sholler et al 18 In short, the left sided flow velocity time integral is obtained by placing the pulse wave Doppler at the aortic valve level in apical five chamber view. The heart rate was measured from the beginning of one ejection cycle to the beginning of next ejection cycle.…”

Section: Methodsmentioning

confidence: 99%

Echocardiographic measures of ventricular function and pulmonary artery size: prognostic markers of congenital diaphragmatic hernia?

et al. 2011

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Objective: To compare echocardiographic measures of biventricular function and pulmonary artery size in infants with congenital diaphragmatic hernia (CDH) and normal controls, and examine their correlation, if any, with outcomes in CDH.Study Design: We included consecutive neonates (<1 month old) with CDH and term controls without structural heart defects. Clinical and outcomes data were recorded and echocardiograms evaluated for right ventricular (RV) and left ventricular (LV) myocardial performance index (MPI), cardiac output index (CI) and McGoon index, among others. Statistical analyses (SPSS version 17, SPSS, Chicago, IL, USA) included between-group comparisons, using analysis of variance and w 2 -test and binary regression, with significance set at P<0.05.Result: Infants with CDH (n ¼ 34) were comparable with controls (n ¼ 35) in their age, weight, gestational age and gender. CDH was left sided in 24 (70%) neonates. Extracorporeal membrane oxygenation (ECMO) was required in 15 (45%) neonates; 18 (53%) infants survived. MPIs, CI and eccentricity index in systole were significantly worse in the CDH group, compared with controls and among CDH infants who died, compared with survivors. Infants with CDH who died or needed ECMO had significantly impaired MPIs and CI than survivors. On regression analyses, LV CI and MPIs were independently associated with mortality.Conclusion: Infants with CDH had significantly impaired ventricular function and pulmonary hypertension, compared with controls. In the CDH group, LV dysfunction was associated with death and adverse outcomes. Further studies incorporating echocardiographic indices as prognostic markers of CDH are warranted.

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Echo Doppler assessment of cardiac output and its relation to growth in normal infants

Cited by 34 publications

References 18 publications

Echocardiographic correlates of persistent pulmonary hypertension of the newborn

Echocardiographic correlates of persistent pulmonary hypertension of the newborn

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

Echocardiographic measures of ventricular function and pulmonary artery size: prognostic markers of congenital diaphragmatic hernia?

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